Adaptive Response to Dominant Lethality of Mature (Class A) and Immature (Class B) Oocytes ofD. Melanogasterto Low Doses of Ionizing Radiation: Effects in Repair-proficient (yw) and Repair-deficient Strains (Mei 41D5and Mus 302D1)

Fritz-Niggli, H; Schaeppi-Buechi, C.

doi:10.1080/09553009114550161

Cited by 38 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other mutational studies, Fritz-Niggli and Schaeppi-Buechi (24) (25) or 5 cGy of 7-rays (26). Azzam et al (27) also found this same end point to be reducked in a normal human fibroblast line (AG1522) exposed to chronic radiation (4.25 Gy at 0.003 Gy/min) before being challenged immediately with 4.25 Gy given in less than 2 min.…”

Section: Worldwide Experments With Other End Pointsmentioning

confidence: 85%

The Adaptive Response in Radiobiology: Evolving Insights and Implications

Wolff¹

1998

Environmental Health Perspectives

105

View full text Add to dashboard Cite

The first of the regularly reproducible experiments to show that very low doses of ionizing radiation, like very low doses of chemical agents, could induce mechanisms whereby cells become better fit to cope with subsequent exposures to high doses were carried out on the induction of chromosome aberrations in cultures of human lymphocytes. If cells that had been exposed to a very low dose (1 cGy) of X rays were subsequently exposed to a relatively high dose (1 Gy), approximately half as many chromosome breaks were induced. Subsequent experiments showed that this adaptive response to low doses requires a certain minimal dose before it becomes active; occurs only within a relatively small window of dose; is dose-rate dependent; and depends on the genetic constitution of the people or animals exposed, with some being unresponsive. It was further shown that the response to the low-dose preexposure was not instantaneous but took approximately 4 to 6 hr to become fully active, and could be prevented if during this period protein synthesis was inhibited, i.e., a necessary protein (enzyme) was being induced. In fact, subsequent experiments with two-dimensional gel electrophoresis showed new proteins in cells irradiated with 1 to 2 cGy. The adaptation induced by low doses of radiation was therefore attributed to the induction of a novel efficient chromosome break repair mechanism that if active at the time of challenge with high doses would lead to less residual damage. This hypothesis was strengthened by a series of experiments in which it was found that inhibitors of poly(ADP-ribose)polymerase, an enzyme implicated in DNA strand break rejoining, could prevent the adaptive response. Although the phenomenon is well established in cellular systems, it is still problematical as to whether or not it will have any utility in establishing risks of ionizing radiation to humans. Newer experiments have now been carried out on the mechanisms underlying the effect and whether or not the effect can manifest itself as a decrease in the number of induced cancers and radiation-induced mortality. Experiments with restriction enzymes now indicate that doublestrand breaks in DNA can be triggering events in adaptation. In addition, preliminary experiments on the survival of whole-body irradiated mice have shown that multiple exposures to low adapting doses can have profound effects on survival, and other experiments have shown that adaptation can affect the induction of thymic lymphoma in irradiated mice. It therefore appears that the initial experiments behind the adaptive response have led to a vigorous worldwide effort to understand the basic mechanisms behind it. This effort is stimulated both by a desire to understand the basic cell biology behind the response and a desire to see if indeed this phenomenon affects the estimation of risks of low-level radiation exposure.Environ Health Perspect 106(Suppl 1):277-283 (1998). http.//ehpnetl.niehs.nih.gov/1998/Suppl-1/277-283wolff/abstract.html

show abstract

Section: Worldwide Experments With Other End Pointsmentioning

confidence: 85%

The Adaptive Response in Radiobiology: Evolving Insights and Implications

Wolff¹

1998

Environmental Health Perspectives

105

View full text Add to dashboard Cite

show abstract

“…Therefore, DNA is protected from any physical or chemical impairment when the chromatin is unable to do so, consolidating the genomic material to produce a minute, more hydrodynamically-formed cell [18]. DNA repair systems are known to be present in oocytes, having their activity influenced in various ways: genetic and environmental [19,20].…”

Section: State Of Knowledgementioning

confidence: 99%

“…On the other hand, the distinct possibility that DNA repair in oocytes may be enabled by radiation damage is inferred in a paper by Fritz-Niggli and Schaeppi-Buech [19]. An adaptive response to the effects of low doses of X-rays (0.02 Gy prior to 2 Gy) was observed in Drosophila melanogaster oocytes, and suggested the existence of 'a repair stimulating effect' of low doses for both the repair-deficient strains, as well as for the highly radiosensitive mature oocytes.…”

Section: State Of Knowledgementioning

confidence: 99%

Sperm epigenetic profile and risk of cancer

Wdowiak

2015

J Pre Clin Clin Res.

View full text Add to dashboard Cite

Introduction and objective. The integrity, stability and composition of sperm chromatin are of great importance in the fertilizing potential of male gametes and their capacity to support normal embryonic development. In this study, the author presents the current state of knowledge about the sperm epigenetic profile and risk of cancer. Abbreviated description of the state of knowledge. The obtaining of pregnancy and the state of health of the baby depends on the quality of the genetic material of both the female and the male. Health behaviours and environmental factors directly affect the quality of sperm, as well as the human egg cell and, consequently, on the reproductive capabilities, the course of pregnancy and the state of the newborn. There exist two thoroughly investigated epigenetic modifications: DNA methylation and histone modifications. The process of DNA methylation can be also a fundamental factor contributing to the development of cancer, where epigenotype undergoes significant modifications. When considering numerous DNA aberrations in the male gamete, the most commonly encountered is DNA fragmentation, particularly in infertile subjects. Surprisingly, an intracytoplasmatic sperm injection study of mice oocytes, using spermatozoa with a high DNA Fragmentation Index (DFI), revealed that a considerable percentage of adults born as a result of this method, showed a significant increase in the incidence of abnormal behavioural tests, malformations, cancer and signs of premature aging. Summary. The issue of assisted procreation raises the need to look for an appropriate treatment for males with sperm chromatin abnormalities. As a result, the fight against smoking addiction becomes the obvious necessity. Moreover, the reasonable solution nowadays seems to be supplementation with micronutrients and folic acid. It has been proved that the process of DNA fragmentation is a phenomenon that intensifies over time. Therefore, there should be a pursuance for, as close as possible, to the moment of ejaculation, application of semen to reproductive techniques. Finally, epigenetic changes are suspected of being one of the factors responsible for the deterioration of male sperm parameters observed in recent decades.

show abstract

“…The induction of radioadaptive response was first reported by Olivieri et al (1984) who showed that the frequency of chromatid aberrations were down to 50% less than expected after exposure to 1.5 Gy of x-rays. Many articles have demonstrated radioadaptive response in plant cells (Cortes et al 1990), insects (Fritz-Niggli and Schaeppi-Buechi 1991), Chinese hamster V79 cells (Ikushima 1987(Ikushima , 1989a(Ikushima , 1989b, cultured human lymphocytes (Shadley and Wolff 1987;Wolff et al 1988;Sankaranarayanan et al 1989;Shadley and Wiencke 1989;Ghiassi-nejad et al 2002), embryonic and HeLa cells (Ishii and Watanabe 1996), occupationally exposed persons (Barquinero et al 1995;Gourabi and Mozdarani 1998), cultured animal lymphocytes (Wojcik and Tuschl 1990), and in vivo studies on laboratory animals (Bosi and Olivieri 1989;Cai and Liu 1990;Liu et al 1992;Farooqi and Kesavan 1993). However, there are reports indicating lack of radioadaptive response in cultured human lymphocytes (Mortazavi et al 2000;Mortazavi et al 2003b;Joksic and Petrovic 2004).…”

Section: Introductionmentioning

confidence: 99%

Increased Radioresistance to Lethal Doses of Gamma Rays in Mice and Rats after Exposure to Microwave Radiation Emitted by a GSM Mobile Phone Simulator

et al. 2012

View full text Add to dashboard Cite

The aim of this study was to investigate the effect of pre-irradiation with microwaves on the induction of radioadaptive response. In the 1(st) phase of the study, 110 male mice were divided into 8 groups. The animals in these groups were exposed/sham-exposed to microwave, low dose rate gamma or both for 5 days. On day six, the animals were exposed to a lethal dose (LD). In the 2(nd) phase, 30 male rats were divided into 2 groups of 15 animals. The 1(st) group received microwave exposure. The 2(nd) group (controls) received the same LD but there was no treatment before the LD. On day 5, all animals were whole-body irradiated with the LD. Statistically significant differences between the survival rate of the mice only exposed to lethal dose of gamma radiation before irradiation with a lethal dose of gamma radiation with those of the animals pre-exposed to either microwave (p=0.02), low dose rate gamma (p=0.001) or both of these physical adapting doses (p=0.003) were observed. Likewise, a statistically significant difference between survival rates of the rats in control and test groups was observed. Altogether, these experiments showed that exposure to microwave radiation may induce a significant survival adaptive response.

show abstract

Adaptive Response to Dominant Lethality of Mature (Class A) and Immature (Class B) Oocytes ofD. Melanogasterto Low Doses of Ionizing Radiation: Effects in Repair-proficient (yw) and Repair-deficient Strains (Mei 41^D5and Mus 302^D1)

Cited by 38 publications

References 19 publications

The Adaptive Response in Radiobiology: Evolving Insights and Implications

The Adaptive Response in Radiobiology: Evolving Insights and Implications

Sperm epigenetic profile and risk of cancer

Increased Radioresistance to Lethal Doses of Gamma Rays in Mice and Rats after Exposure to Microwave Radiation Emitted by a GSM Mobile Phone Simulator

Contact Info

Product

Resources

About