Added Value with Extended NO Analysis

Högman, Marieann; Meriläinen, Pekka

doi:10.1016/b978-0-44-462613-4.00011-8

Cited by 1 publication

(1 citation statement)

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“…Only a few volatile compounds in exhaled breath have been investigated in real-time measurements by PTR-MS [71][72][73], PTR-TOF-MS [74,75], SIFT-MS [76][77][78][79], laser spectrometry or sensors [80][81][82][83][84]: among them are isoprene, acetone, 2-pentanone, dimethylsulfide, methyl acetate [67], eucalyptol [85], hydrogen, methane [21,86], ethane [87,88], carbon monoxide [89][90][91][92][93], carbon dioxide ( 12 CO 2 and 13 CO 2 [94,95]), nitric oxide (NO) [96][97][98][99][100] and water (H 2 O and HDO [101,102]). In the future, real-time measurements should be performed for all volatile compounds, giving rise to the possibility of modelling the flow of these compounds within the human body as well as their production and rate of metabolism.…”

Section: Volatile Organic Compounds In Breathmentioning

confidence: 99%

A review of the volatiles from the healthy human body

et al. 2014

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A compendium of all the volatile organic compounds (VOCs) emanating from the human body (the volatolome) is for the first time reported. 1840 VOCs have been assigned from breath (872), saliva (359), blood (154), milk (256), skin secretions (532) urine (279), and faeces (381) in apparently healthy individuals. Compounds were assigned CAS registry numbers and named according to a common convention where possible. The compounds have been grouped into tables according to their chemical class or functionality to permit easy comparison. Some clear differences are observed, for instance, a lack of esters in urine with a high number in faeces. Careful use of the database is needed. The numbers may not be a true reflection of the actual VOCs present from each bodily excretion. The lack of a compound could be due to the techniques used or reflect the intensity of effort e.g. there are few publications on VOCs from blood compared to a large number on VOCs in breath. The large number of volatiles reported from skin is partly due to the methodologies used, e.g. collecting excretions on glass beads and then heating to desorb VOCs. All compounds have been included as reported (unless there was a clear discrepancy between name and chemical structure), but there may be some mistaken assignations arising from the original publications, particularly for isomers. It is the authors' intention that this database will not only be a useful database of VOCs listed in the literature, but will stimulate further study of VOCs from healthy individuals. Establishing a list of volatiles emanating from healthy individuals and increased understanding of VOC metabolic pathways is an important step for differentiating between diseases using VOCs.

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