Addiction disorders: a need for change. Proposal for a new management. Position paper of SIA, Italian Society on Alcohol

Testino, Gianni; Bottaro, Luigi Carlo; Patussi, Valentino; Scafato, Emanuele; Addolorato, Giovanni; Leone, Silvia; Renzetti, Doda; Balbinot, Patrizia; Greco, Giovanni; Fanucchi, Tiziana; Schiappacasse, Giorgio; Cardinale, Paola; Allosio, Pierluigi; Pellicano, Rinaldo; Caputo, Fabio

doi:10.23736/s0026-4806.18.05741-5

Cited by 44 publications

(1 citation statement)

References 33 publications

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“…This review summarizes the evidences on the triangular interaction between gut microbiota, immune system and liver, in health and disease. Since the epidemiology of chronic liver diseases is changing, due to the decreasing rate of viral hepatitis and the increasing new epidemic of a wide spectrum of alcoholic and non-alcoholic fatty liver disease (NAFLD) [6,7], we focus our attention on non-viral hepatitis. Furthermore, due to the link reported between severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection and hepatic dysfunctions, we outline the emerging role of the gut virome in liver diseases.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota and Liver Interaction through Immune System Cross-Talk: A Comprehensive Review at the Time of the SARS-CoV-2 Pandemic

Scarpellini

Fagoonee

Rinninella

et al. 2020

JCM

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Background and aims: The gut microbiota is a complex ecosystem containing bacteria, viruses, fungi, yeasts and other single-celled organisms. It is involved in the development and maintenance of both innate and systemic immunity of the body. Emerging evidence has shown its role in liver diseases through the immune system cross-talk. We review herein literature data regarding the triangular interaction between gut microbiota, immune system and liver in health and disease. Methods: We conducted a search on the main medical databases for original articles, reviews, meta-analyses, randomized clinical trials and case series using the following keywords and acronyms and their associations: gut microbiota, microbiome, gut virome, immunity, gastrointestinal-associated lymphoid tissue (GALT), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steato-hepatitis (NASH), alcoholic liver disease, liver cirrhosis, hepatocellular carcinoma. Results: The gut microbiota consists of microorganisms that educate our systemic immunity through GALT and non-GALT interactions. The latter maintain health but are also involved in the pathophysiology and in the outcome of several liver diseases, particularly those with metabolic, toxic or immune-mediated etiology. In this context, gut virome has an emerging role in liver diseases and needs to be further investigated, especially due to the link reported between severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection and hepatic dysfunctions. Conclusions: Changes in gut microbiota composition and alterations in the immune system response are involved in the pathogenesis of metabolic and immune-mediated liver diseases.

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Section: Introductionmentioning

confidence: 99%