Adding Combined Oral Contraceptives or Metformin to Laser Treatment in Polycystic Ovarian Syndrome Hirsute Patients

Dorgham, Nevine A.; Sharobim, Amin; Haggag, Hisham; El‐Kalioby, Mona; Dorgham, Dina A.

doi:10.36849/jdd.5652

Cited by 10 publications

(17 citation statements)

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“…However, treatment with COC alone or combined with metformin was superior to treatment with metformin alone regarding hirsutism scores 57 . Similar results have been found in additional studies 29,30 …”

Section: Pharmacologic Treatmentsupporting

confidence: 74%

“…29 Similarly, a trial of 150 patients randomized to receive treatment with metformin, metformin and laser hair removal, or COCs and laser hair removal found patients treated with COCs to have significantly better improvements in hirsutism life quality index. 30 Given that COCs are a standard treatment regimen to treat PCOS, dermatologists should None reported Improves acne Improves hirsutism 13,54 Depression, suicidal ideation 5 weeks 72 recommend third and fourth generation COCs for PCOS patients with co-morbid FPHL to manage hair loss and paradoxical hirsutism.…”

Section: Combined Oral Contraceptive Pills: Effects On Hirsutismmentioning

confidence: 99%

“…A randomized, parallel open‐label trial comparing PCOS patients using a COC and spironolactone with patients taking metformin alone found that patients taking a COC had significantly greater decreases in hirsutism scores than those taking metformin alone 29 . Similarly, a trial of 150 patients randomized to receive treatment with metformin, metformin and laser hair removal, or COCs and laser hair removal found patients treated with COCs to have significantly better improvements in hirsutism life quality index 30 . Given that COCs are a standard treatment regimen to treat PCOS, dermatologists should recommend third and fourth generation COCs for PCOS patients with co‐morbid FPHL to manage hair loss and paradoxical hirsutism.…”

Section: Pharmacologic Treatmentmentioning

confidence: 99%

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A practical approach to the management of hair loss in patients with polycystic ovary syndrome

Klein

Karim

et al. 2023

Acad Dermatol Venereol

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Female patterned hair loss (FPHL) is a common form of androgenetic alopecia in women and is characterized by a hormonally directed diffuse hair loss on the scalp. Management of FPHL is well described in the literature; however, treatment of FPHL in patients with co-morbid polycystic ovarian syndrome (PCOS), an endocrinologic condition found in reproductive-aged women, has not yet been reviewed. Due to the different pathomechanism of the diseases and complexity of FPHL in PCOS patients, this study aimed to review current diagnosis and management approaches for hair loss in PCOS patients specifically and highlight the growing need for more research in this growing patient population.

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Section: Pharmacologic Treatmentsupporting

confidence: 74%

Section: Combined Oral Contraceptive Pills: Effects On Hirsutismmentioning

confidence: 99%

Section: Pharmacologic Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

A practical approach to the management of hair loss in patients with polycystic ovary syndrome

Klein

Karim

et al. 2023

Acad Dermatol Venereol

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“…Dorgham N. et al believed that infertile patients with polycystic ovary syndrome had endocrine and metabolic disorders, with high levels of luteinizing hormone. Under the regulation of estrogen, ovarian blood vessels dilated significantly, so vascular resistance decreased and the blood flow speed increased [ 6 ]. Therefore, Li N. et al, in addition to accumulated teaching experience, focused on observing the changes of ovarian hemodynamics and signal intensity in the TVCDS examination of suspected infertility patients with polycystic ovary syndrome, which was conducive to the definite diagnosis of the disease [ 7 ].…”

Section: Literature Reviewmentioning

confidence: 99%

[Retracted] Image Analysis of TVCDS in Infertile Patients with Polycystic Ovary Syndrome

Duan

Luo

Yang

et al. 2022

Contrast Media & Molecular Imaging

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In order to analyze and examine the TVCDS images of infertile patients, this paper conducted an in-depth study based on the symptoms of polycystic ovary syndrome. Through the sample size estimation method, mathematical analysis, and other methods, the image examination of the polycystic ovary in TVCDS was successfully analyzed. 86 cases of infertile patients with PCS were divided into a control group treated with clomiphene alone and an observation group treated with clomiphene combined with TCM periodic therapy, with 43 patients in each group. The therapeutic effects of the two groups were compared and analyzed. Results show that the treatment effective rate and pregnancy success rate of the observation group were 95.35% and 88.37%, respectively, and those of the control group were 83.72% and 76.74%, respectively. The difference between the two groups was statistically significant P < 0.05 . It was understood that the main pathogenesis of polycystic ovary syndrome is the abnormal balance of kidney, qi, and blood meridians. Thus, the balance of kidney-anemone-chong Ren-uprisal is broken and the result is infertility symptoms or irregular menstruation. After a study on TVCDS in infertile patients, it was observed that the levels of progesterone (P) and luteinizing hormone (LH) in patients with irregular menstruation were significantly increased. The increase was higher than that in the control group, with an overall negative rate of 4.00%, compared with 18.00% of the control group, showing a significant difference. It also indicates that TVCDS image examination has a very significant effect on improving menstrual irregularities and reducing the incidence of adverse reactions.

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“…This study had a moderate RoB, largely because outcome assessors were not blinded and potential conflict of interest. Thus, three studies [21][22][23] compared COCP with a no-treatment control group and results, including reported adverse events are shown in Table 2. One study 24 compared COCP with placebo, and the same study 24 also compared COCP with lifestyle, these results are shown in Tables 3 and 4.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Combined oral contraceptive pill compared with no medical treatment in the management of polycystic ovary syndrome: A systematic review

Forslund

Melin

Alesi

et al. 2023

Clinical Endocrinology

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Objective As part of the update of the International Evidence‐Based Guidelines for the Assessment and Management of polycystic ovary syndrome (PCOS), a systematic review was performed to inform evidence‐based recommendations. Design Systematic review. Only randomised controlled trial were included. Patients Women with PCOS; the use of combined oral contraceptive pills (COCP) was compared with no medical treatment. Measurements Outcomes were designed in collaboration with clinical experts, researchers, and consumers. Critical outcomes included hirsutism, irregular cycles, quality of life, body mass index (BMI), and weight. Results 1660 publications were identified, but only four studies were included. No studies could be combined for meta‐analysis. COCP treatment improved cycle regularity compared with no medical treatment (100% vs. 0%, with low certainty of evidence). COCP showed no difference in improvement of hirsutism or BMI compared with placebo or lifestyle; a lower weight after COCP compared with no treatment (mean difference [MD] −8.0 (95% confidence interval, CI −11.67); −4.33 kg); and improvement in quality of life (MD 1.2 [95% CI 0.96]; 1.44), but these results were all very low certainty of evidence. Conclusion Results show that COCP benefit cycle regulation, but other benefits or potential adverse effects were only identified with very low certainty of evidence. The COCP is frontline medical treatment in PCOS, but this is still based on established efficacy in the broader general population. Our results show that research in PCOS is seriously lacking and should be prioritised to capture core reproductive, metabolic and psychological outcomes important in PCOS.

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Adding Combined Oral Contraceptives or Metformin to Laser Treatment in Polycystic Ovarian Syndrome Hirsute Patients

Cited by 10 publications

References 0 publications

A practical approach to the management of hair loss in patients with polycystic ovary syndrome

A practical approach to the management of hair loss in patients with polycystic ovary syndrome

[Retracted] Image Analysis of TVCDS in Infertile Patients with Polycystic Ovary Syndrome

Combined oral contraceptive pill compared with no medical treatment in the management of polycystic ovary syndrome: A systematic review

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