Adding complexity to soil food webs: Myxobacteria have broad predation spectra with bacteria, yeasts and filamentous fungi in vitro

Groß, Verena; Reinhard, Anne; Petters, Sebastian; Pichler, Michelle; Urich, Tim

doi:10.1016/j.ejsobi.2023.103508

Cited by 6 publications

(1 citation statement)

References 75 publications

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“…Among them, the Myxobacteria act potentially as key taxa within the microbial food web(4, 6, 7). Characterized as generalist predators, Myxobacteria feed on a vast array of microorganisms, including diverse bacterial and fungal species(8). Their predatory nature offers promising avenues in combating plant infections.…”

Section: Introductionmentioning

confidence: 99%

Fatty Acid Metabolism and The Oxidative Stress Response Support Bacterial Predation

Jain,

Le,

Bertaux

et al. 2023

Preprint

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Despite growing awareness for their importance in soil ecology, the genetic and physiological traits of bacterial predators are still relatively poorly understood. In the course of aMyxococcus xanthuspredator evolution experiment, we discovered a class of genotypes leading to enhanced predation against evolutionary-diverse species. Genetics and RNAseq analyses link this improved predation capacity to the fine-tuned control of intracellular Acetyl-CoA pools following increased activation of fatty acid beta-oxidation. Notably, these metabolic changes led to the constitutive expression of antioxidant genes. This is critical to the predatory advantage of the evolved strain because this response shields predatory cells against Reactive Oxygen Species (ROS), which arise following contact-dependent killing of the prey cells. Globally, these findings suggest that predators turning on lipid metabolism serves two purposes: energy production and adaptation to oxidative stress originating from interaction with their prey.

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