Adding Suicide Prevention to the Triple Advantages of Injectable Long-Acting Second-Generation Antipsychotics

Pompili, Maurizio

doi:10.3389/fpsyt.2019.00931

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…In addition to improving adherence, which can lead to better clinical and functional outcomes, treatment administration involves a frequent contact with mental health services. This can prevent social isolation and provide more support to counteract potential negative beliefs about psychosis, two factors associated with suicide risk 81 . Importantly, in both groups, it is paramount to offer enough education about suicide to families and health professionals so that they can detect and respond adequately to direct or indirect suicidal communication, since about half of all suicides communicate their suicidal intentions prior to committing suicide 82 …”

Section: Discussionmentioning

confidence: 99%

“…This can prevent social isolation and provide more support to counteract potential negative beliefs about psychosis, two factors associated with suicide risk. 81 Importantly, in both groups, it is paramount to offer enough education about suicide to families and health professionals so that they can detect and respond adequately to direct or indirect suicidal communication, since about half of all suicides communicate their suicidal intentions prior to committing suicide. 82 Overall, our results confirm previous risk factors for SI, but highlight that not all risk factors apply to all patients presenting with SI.…”

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confidence: 99%

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Trajectories of suicidal ideation after first‐episode psychosis: a growth mixture modeling approach

Salagre

Grande

Jiménez

et al. 2021

Acta Psychiatr Scand

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Objective: The period immediately after the onset of first-episode psychosis (FEP) may present with high risk for suicidal ideation (SI) and attempts, although this risk may differ among patients. Thus, we aimed to identify trajectories of SI in a 2-years follow-up FEP cohort and to assess baseline predictors and clinical/functional evolution for each trajectory of SI. Methods: We included 334 FEP participants with data on SI. Growth mixture modeling was used to identify trajectories of SI. Putative sociodemographic, clinical, and cognitive predictors of the distinct trajectories were examined using multinomial logistic regression.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Trajectories of suicidal ideation after first‐episode psychosis: a growth mixture modeling approach

Salagre

Grande

Jiménez

et al. 2021

Acta Psychiatr Scand

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“…For example, findings such as gray matter deficits or abnormalities in frontal-based control functions could potentially be used to measure target engagement of novel, anti-suicide agents. For example, the potential anti-suicidal effects of long-acting injectable medications (Pompili, 2019) could be examined using brain imaging technologies with an eye toward specific effects on the brain.…”

Section: Discussion and Clinical Implicationsmentioning

confidence: 99%

The neurobiology of suicide in psychosis: A systematic review

Girgis

2020

J Psychopharmacol

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The lifetime risk of dying by suicide in schizophrenia and related psychoses has been estimated to be approximately between 5% and 7%, though some have estimated that the number is closer to 10%. The highest risk for suicide occurs within the first year after presentation, when patients have a 12 times greater risk of dying by suicide than the general population, or a 60% higher risk compared with patients in other phases of psychosis, although the risk continues for many years. Some 31% of all deaths in first and early episode samples are due to suicide. Studies in individuals at clinical high-risk for psychosis (CHR) or with attenuated positive symptoms also demonstrate that suicidality is common and problematic in these individuals. Therefore, suicide in psychosis is a particularly severe problem. In order to develop interventions aimed at reducing the risk of suicide in psychotic individuals, it will be critical to understand the neurobiology of suicide in psychosis. In this paper, I report on the results of a systematic review of the work done to date on the neurobiology of suicide in psychosis and on suicidality in the CHR period. I will also identify gaps in knowledge and discuss future strategies for studying the neurobiology of suicidality in psychosis that may help to disentangle the links between suicide and psychosis and, by doing so, allow us to gain a greater understanding of the relationship between suicide and psychosis, which is critical for developing interventions aimed at reducing the risk of suicide in psychotic individuals.

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“…A better understanding of whether LAI treatment may decrease suicide risk by indirectly acting on a range of risk factors for suicide specific to patients with schizophrenia is of significant clinical importance. Pompili ( 176 ) suggested that long-acting injections of second-generation antipsychotics can be an effective treatment strategy to improve medication adherence and prevent suicide risk.…”

Section: Suicide Risk Formulation and Suicide Prevention Strategies In Schizophreniamentioning

confidence: 99%

The Importance of Suicide Risk Formulation in Schizophrenia

et al. 2021

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Suicide is a cause of early mortality in nearly 5% of patients with schizophrenia, and 25–50% of patients with schizophrenia attempt suicide in their lifetime. Evidence points to numerous individual, clinical, social, and psychological risk factors for suicide in patients with schizophrenia. Although recognizing suicidal risk factors in schizophrenia is extremely important in suicidal risk assessment, we have recently witnessed a change in suicide risk management that shifts the focus from suicide risk assessment to suicide risk formulation. Suicide risk formulation is dependent on the data gathered in the suicide risk assessment and assigns a level of suicide risk that is indispensable for the choice of treatment and the management of patients with a high suicidal risk. In this article, we extend the suicide risk formulation model to patients with schizophrenia. Suicide risk formulation results from four different areas that help clinicians collect as much information as possible for the management of suicidal risk. The four distinct judgments comprise risk status (the risk relating to the specific group to which the patient belongs), risk state (the risk for the person compared with his baseline or another reference point in the course of his life), available resources (on whom the person can count during a crisis) and foreseeable events (which can exacerbate the crisis). In schizophrenia, the suicide risk formulation model allows the clinician to evaluate in depth the clinical context of the patient, the patient's own history and patient-specific opportunities for better choosing and applying suicide prevention strategies.

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Adding Suicide Prevention to the Triple Advantages of Injectable Long-Acting Second-Generation Antipsychotics

Cited by 7 publications

References 20 publications

Trajectories of suicidal ideation after first‐episode psychosis: a growth mixture modeling approach

Trajectories of suicidal ideation after first‐episode psychosis: a growth mixture modeling approach

The neurobiology of suicide in psychosis: A systematic review

The Importance of Suicide Risk Formulation in Schizophrenia

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