Adding Weekly Intramuscular Progesterone to a Twice Daily Vaginal Progesterone Capsule for Luteal Phase Support in IVF/ICSI Cycles Results in Similar Live Birth Rates

Gari, S.; Al‐Jaroudi, Dania

doi:10.5935/1518-0557.20210040

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Likewise, two recently published retrospective studies compared combined IM and vaginal progesterone vs. either IM or vaginal progesterone only LPS. Both studies showed similar outcomes for all study arms (7,8). Similarly, no significant differences were found between low-dose vs. high dose vaginal agents, short vs. long protocol, micronized vs. synthetic formulation or other administration forms (vaginal ring, gel) (3).…”

Section: Progesterone Routes Of Administration In Fresh Embryo Transfersmentioning

confidence: 92%

Luteal phase support in fresh and frozen embryo transfers

Greenbaum

Athavale

Klement

et al. 2022

Front. Reprod. Health

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ContextLuteal phase support (LPS) has become an essential component of IVF protocols following both fresh and frozen embryo transfers, yet there is still controversy with regards to the optimal protocol of LPS to enhance treatment outcome.Search strategyA search via PubMed for all the selected topics was limited to publications from the past 10 years and to English language. We subsequently searched the reference lists of retrieved articles. Where available, RCTs were chosen over non-randomized studies. Here we provide an updated review of the current literature on various issues relating to LPS, in both fresh and frozen embryo transfers. The timing of LPS initiation as well as the route of administration and dosing are discussed for both fresh and frozen transfers. A separate discussion for frozen thawed embryo transfer in natural cycles and non-ovulatory cycles is presented.ConclusionsWe present data that supports the use of Progesterone LPS in fresh and frozen embryo transfers. No benefits were found to the addition of hCG or estradiol to progesterone LPS in fresh transfers, however GnRH agonist may have a role. IM Progesterone was not advantageous over vaginal progesterone in fresh transfers but was superior in frozen transfers. The timing of LPS introduction, the interval to embryo transfer, as well as the serum concentration of progesterone, have significant effects on the success of the treatment.

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Section: Progesterone Routes Of Administration In Fresh Embryo Transfersmentioning

confidence: 92%

Luteal phase support in fresh and frozen embryo transfers

Greenbaum

Athavale

Klement

et al. 2022

Front. Reprod. Health

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“…Some authors have also experimented the administration of two routes of progesterone; weekly intramuscular progesterone in addition to a classic luteal phase supported by vaginal progesterone versus vaginal progesterone alone with similar results between the two treatments after fresh embryo transfer (21).…”

Section: Introductionmentioning

confidence: 99%

Systematic use of long-acting intramuscular progesterone in addition to oral dydrogesterone as luteal phase support for single fresh blastocyst transfer: A pilot study

et al. 2022

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ObjectiveThe need of luteal support after FET is no longer to be proven. Different routes of progesterone administration are available with interindividual differences in metabolization and serum progesterone levels, the latter being highly correlated with pregnancy and delivery rates. The administration of 2 different routes of progestogen significantly improves success rates in FET. The aim of the current study was to investigate the added value to combine intramuscular administration of progesterone to dydrogesterone in fresh embryo transfer.MethodsThis is a retrospective study from prospectively collected data. Patient, aged between 18 and 43 years old, had received a fresh blastocyst transfer between January 2021 and June 2021. In the first group, all patients received only oral dydrogesterone 10mg, three times a day, beginning the evening of oocyte retrieval. In the second group, patients received, in addition to dydrogesterone, a weekly intramuscular injection of progesterone started the day of embryo transfer. Primary endpoint was ongoing pregnancy rate.Results171 fresh single blastocyst transfers have been performed during this period. 82 patients were included in “dydrogesterone only” and 89 patients in “dydrogesterone + IM”. Our two groups were comparable except for body mass index. After adjustment on BMI, our two groups were comparable regarding implantation rate, early pregnancy rate (46.1 versus 54.9, OR 1.44 [0.78; 2.67], p=0.25) miscarriage rate, ongoing pregnancy rate (30.3 versus 43.9, OR 1.85 [0.97; 3.53] p= 0.06).ConclusionUsing systematically long acting intramuscular progesterone injection in addition to oral dydrogesterone as luteal phase support seems to have no significant impact on IVF outcomes when a single fresh blastocyst transfer is performed.

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Adding Weekly Intramuscular Progesterone to a Twice Daily Vaginal Progesterone Capsule for Luteal Phase Support in IVF/ICSI Cycles Results in Similar Live Birth Rates

Cited by 2 publications

References 20 publications

Luteal phase support in fresh and frozen embryo transfers

Luteal phase support in fresh and frozen embryo transfers

Systematic use of long-acting intramuscular progesterone in addition to oral dydrogesterone as luteal phase support for single fresh blastocyst transfer: A pilot study

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