Addison’s Disease

Kannan, C. R.

doi:10.1007/978-1-4613-1001-3_2

Cited by 8 publications

(8 citation statements)

References 264 publications

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“…Currently, in the developed countries the most common cause of primary adrenal failure is autoimmunity, causing up to 75-80% of the cases of adrenal insufficiency, while tuberculosis is the second most frequent cause, responsible for up to 15-20% of the cases. Many other rare causes are involved in 5-7% of patients (5,6). Consequently, autoimmune Addison's disease (AAD) can be considered as a synonym of the idiopathic form of adrenal failure.…”

Section: Autoimmune Adrenal Insufficiencymentioning

confidence: 99%

Adrenal and ovarian autoimmunity

Betterle

Volpato²

1998

European Journal of Endocrinology

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Section: Autoimmune Adrenal Insufficiencymentioning

confidence: 99%

Adrenal and ovarian autoimmunity

Betterle

Volpato²

1998

European Journal of Endocrinology

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“…The causes of secondary adrenocortical insufficiency are primary pituitary disorders or causes secondary to hypothalamic disorders such as tumors, apoplexy, infection, trauma, immunological disorders, and adverse reactions to drugs and irradiation to the sella (9). The clinical history of the present case shows that pituitary apoplexy, trauma, and irradiation to the sella were unlikely.…”

Section: Discussionmentioning

confidence: 66%

Adrenocortical Insufficiency Associated with Long-term High-dose Fosfestrol Therapy for Prostatic Carcinoma.

et al. 1999

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A 59-year-old manwas admitted to our hospital because of muscular pain, weakness, and anorexia. He had been treated with 600 mg/day of fosfestrol, a synthetic estrogen, for 10 years for prostatic carcinoma. Endocrinological studies demonstrated adrenocortical insufficiency due to inadequate ACTHsecretion. After initiation of glucocorticoid replacement therapy, his symptoms subsided rapidly. To our knowledge, an association between estrogenic agents, including fosfestrol, and secondary adrenocortical insufficiency has not been previously reported. Physicians whotreat patients with long-term and high-dose strong estrogenic agents should be cautious about the possible emergence of secondary adrenocortical insufficiency. (Internal Medicine 38: 804-807, 1999)

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“…Данные из-менения связаны с выпадением ингибирующего действия глюкокортикоидов на секрецию ТТГ [70].…”

Section: особенности лечения пациентов с апс взрослыхunclassified

Autoimmune polyglandular syndromes in the adults: the genetic and immunological diagnostic criteria

Larina¹,

Трошина²,

Иванова³

2014

Probl Endokrinol (Mosk)

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At present, four main types of autoimmune polyglandular syndromes (APS) are distinguished. Type 1 APS is associated with candidiasis, primary hypoparathyroidism, and primary adrenal insufficiency developing in the childhood as a result of mutations in the AIRE gene. Type 2 APS involves primary adrenal insufficiency in combination with autoimmune thyroid diseases and/or type 1 diabetes mellitus. Type 3 APS is characterized by the combination of autoimmune thyroid diseases with other endocrine and non-endocrine autoimmune pathologies in the absence of adrenal cortical dysfunction and hypoparathyriodism. Type 4 APS is presented by the combinations of autoimmune diseases other than the aforementioned ones. The above syndromes usually manifest themselves at the age between 20 and 60 years; they are of the polygenic type and associated with the genetic markers, such as HLAII-complex haplotypes, CTLA-4, PTPN22, FOXP3 genes, etc. In addition, the latent forms of APS have been described that occur in the populations much more frequently than the manifest disorders. These latent diseases can exert strong influence on the compensation and risk of complications of the underlying pathology. Of great importance in this context is the timely identification of the groups of patients at risk of developing clinical forms of APS among the subjects presenting with a single endocrine pathology.

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Addison’s Disease

Cited by 8 publications

References 264 publications

Adrenal and ovarian autoimmunity

Adrenal and ovarian autoimmunity

Adrenocortical Insufficiency Associated with Long-term High-dose Fosfestrol Therapy for Prostatic Carcinoma.

Autoimmune polyglandular syndromes in the adults: the genetic and immunological diagnostic criteria

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