Addition of hyperbaric oxygen therapy versus usual care alone for inflammatory bowel disease: A systematic review and meta-analysis

You, Jiuhong; Jiang, Junliang; He, Wenbo; Ma, Hui; Zhou, Mei; Chen, Xinxin; Liu, Qiaoling; Huang, Cheng

doi:10.1016/j.heliyon.2022.e11007

Cited by 8 publications

(6 citation statements)

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“…44 HBOT has been used for a long time as an adjunctive therapy for diabetic wounds, promoting healing by increasing tissue oxygen levels, enhancing perfusion, reducing oedema, inhibiting inflammation and promoting fibroblast proliferation, collagen synthesis and angiogenesis. 9,45,46 In this study, the information and data of 29 RCTs totalling 1764 patients were summarised and analysed, and the results revealed HBOT can effectively improve the rate of complete healing of DFU and reduce the rate of amputation, but it will increase the incidence of adverse reactions, whereas it has no significant effect on the mortality rate. Wound healing is a complex process in which oxygen plays a crucial role.…”

Section: Discussionmentioning

confidence: 99%

“…More intensive monitoring and active care of DFU should be initiated when a possible pre‐ulcer is detected, and treatment should be individualised as early as possible, this preventive treatment may reduce the incidence of more severe DFU and improve the prognosis of the patient to a certain extent 44 . HBOT has been used for a long time as an adjunctive therapy for diabetic wounds, promoting healing by increasing tissue oxygen levels, enhancing perfusion, reducing oedema, inhibiting inflammation and promoting fibroblast proliferation, collagen synthesis and angiogenesis 9,45,46 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Application of hyperbaric oxygen therapy in diabetic foot ulcers: A meta‐analysis

Chen,

Lu,

Wang

et al. 2024

International Wound Journal

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Hyperbaric oxygen therapy (HBOT) has been used in patients with diabetic foot ulcers (DFU) for many years, but its clinical efficacy is still controversial. Therefore, this study explored the efficacy of HBOT applied to DFU by means of meta‐analysis. PubMed, Cochrane Library, Embase, CNKI and Wanfang databases were searched, from database inception to October 2023, and published randomised controlled trials (RCTs) of HBOT in DFU were collected. Two investigators independently screened the collected literature, extracted relevant data and assessed the quality of the literature. Review Manager 5.4 software was applied for data analysis. Twenty‐nine RCTs with 1764 patients were included. According to the combined results, when compared with conventional treatment, HBOT significantly increased the complete healing rate of DFUs (46.76% vs. 24.46%, odds ratio [OR]: 2.83, 95% CI: 2.29–3.51, p < 0.00001) and decreased the amputation rate (26.03% vs. 45.00%, OR: 0.41, 95% CI: 0.18–0.95, p = 0.04), but the incidence of adverse events was significantly higher in patients (17.37% vs. 8.27%, OR: 2.49, 95% CI: 1.35–4.57, p = 0.003), whereas there was no significant difference in the mortality (6.96% vs. 12.71%, OR: 0.52, 95% CI: 0.21–1.28, p = 0.16). Our results suggest that HBOT is effective in increasing the complete healing rate and decreasing the amputation rate in patients with DFUs, but increases the incidence of adverse events, while it has no significant effect on mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Application of hyperbaric oxygen therapy in diabetic foot ulcers: A meta‐analysis

Chen,

Lu,

Wang

et al. 2024

International Wound Journal

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“…accommodating a single patient or several) [2]. By increasing the partial pressure of oxygen in all tissues, hyperbaric oxygen may reduce swelling, activate fibroblasts and macrophages, and increase angiogenesis and collagen formation [3].…”

Section: Dear Editormentioning

confidence: 99%

A severe shortage of hyperbaric units in Egypt: a call to fill this shortage

Ismail

2022

Res Health Serv Reg

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“…Hyperbaric oxygen (HBO) therapy is a medical treatment consisting of breathing pure oxygen in a pressurized chamber [14]. The chamber is pressurized to a level higher than that at sea level, and pure oxygen is delivered at a higher concentration than normal atmospheric levels, allowing for improved oxygen delivery to the body's tissues, which can promote healing and reduce inflammation [15,16].…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy Adjuvant Chemotherapy and Radiotherapy through Inhibiting Stemness in Glioblastoma

Yuen,

Tsai,

Tseng

et al. 2023

CIMB

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Glioblastoma multiforme (GBM) is the most common and deadliest primary brain tumor in adults. Despite the advances in GBM treatment, outcomes remain poor, with a 2-year survival rate of less than 5%. Hyperbaric oxygen (HBO) therapy is an intermittent, high-concentration, short-term oxygen therapy used to increase cellular oxygen content. In this study, we evaluated the effects of HBO therapy, alone or combined with other treatment modalities, on GBM in vitro and in vivo. In the in vitro analysis, we used a 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to assess the effects of HBO therapy alone, a colony formation assay to analyze the effects of HBO therapy combined with radiotherapy and with temozolomide (TMZ), and a neurosphere assay to assess GBM stemness. In the in vivo analysis, we used immunohistochemical staining and in vivo bioluminescence imaging to assess GBM stemness and the therapeutic effect of HBO therapy alone or combined with TMZ or radiotherapy, respectively. HBO therapy did not affect GBM cell viability, but it did reduce the analyzed tumors’ ability to form cancer stem cells. In addition, HBO therapy increased GBM sensitivity to TMZ and radiotherapy both in vitro and in vivo. HBO therapy did not enhance tumor growth and exhibited adjuvant effects to chemotherapy and radiotherapy through inhibiting GBM stemness. In conclusion, HBO therapy shows promise as an adjuvant treatment for GBM by reducing cancer stem cell formation and enhancing sensitivity to chemotherapy and radiotherapy.

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Addition of hyperbaric oxygen therapy versus usual care alone for inflammatory bowel disease: A systematic review and meta-analysis

Cited by 8 publications

References 50 publications

Application of hyperbaric oxygen therapy in diabetic foot ulcers: A meta‐analysis

Application of hyperbaric oxygen therapy in diabetic foot ulcers: A meta‐analysis

A severe shortage of hyperbaric units in Egypt: a call to fill this shortage

Hyperbaric Oxygen Therapy Adjuvant Chemotherapy and Radiotherapy through Inhibiting Stemness in Glioblastoma

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