A systematic study on α-decay half-lives for the nuclei in the range 93 ≤ Z ≤ 118 is done by employing various versions of proximity potentials. To obtain the more reliable results, the deformation terms are included up to hexadecapole (β 4 ) in the spherical-deformed nuclear and Coulomb interaction potentials. The favored α-decays process in this region are categorized as the even-even, odd A, and odd-odd nuclei, first, and second they are grouped into two parts as a ground state to ground state and ground state to isomeric states transition. Due to their root-mean-square deviations (RMSD's) comparison, Bass77 and N go80 have the least values and better compromise in reproducing experimental data. Besides, by considering preformation probability within the cluster formation model, the results validate that the significant reduction in root-mean-square deviations has been obtained for different versions of proximity; Hence detract the deviation between calculated and experimental data.