Additional Prognostic Value of Coronary Flow Reserve in Diabetic and Nondiabetic Patients With Negative Dipyridamole Stress Echocardiography by Wall Motion Criteria

Abstract

Coronary flow reserve provides independent prognostic information in diabetic and nondiabetic patients with known or suspected coronary artery disease and negative dipyridamole stress echocardiography. In particular, a normal CFR off therapy is associated with better and similar survival in the 2 populations.

Benefit of Combined Cardiac Rehabilitation on Exercise Capacity and Cardiovascular Parameters in Patients with Type 2 Diabetes

“…It has been repeatedly reported that hyperglycemia is associated with increased stiffness of large vessels including aorta. Its compliance plays an important role in the coronary artery blood flow modulation, the myocardial workload capacity, and therefore also in the global exercise capacity (Kingwell 2002;Cortigiani et al 2007). As well, impaired exercise capacity in type 2 diabetes is associated not only with anthropometrical parameters, such as age, sex or BMI, but also with left ventricle dysfunction and impairment of cardiac autonomic regulation (Fang et al 2005;Sargin et al 2005;Kasahara et al 2006).…”

Aromatherapy alleviates endothelial dysfunction of medical staff after night-shift work: preliminary observations

“…Night-shift work disrupts the normal biological and/or social diurnal rhythms, which are factors in cardiovascular disease, 1,2 as well as in a widening variety of other chronic diseases, including glucose intolerance, 3,4 hypertension 5,6 and depression. 7,8 Endothelium function, which is strongly associated with the onset and development of cardiovascular disease and its risk factors, [9][10][11] has been shown to be impaired after night-shift work. 12 There is a need for therapeutic options to alleviate the negative impact of working night shifts on the health of medical personnel.…”

Coronary flow velocity reserve predicts survival in non-diabetic patients

“…The prognostic role of echocardiography-derived CFR is widely examined in patients with suspected or known CAD [2][3][4][7][8][9][16][17][18][19][20][21][22][23][24][25]. CFR has a prognostic significance on cardiovascular outcome not only in patients with significant CAD [16], but also in subjects with intermediate (50 to 75%) LAD stenosis [17,18] or angiographically normal or near-normal coronary arteries [4,8,19].…”

“…Recently, diabetes mellitus (DM) and CFR have been found to have a complementary prognostic role for the prediction of cardiovascular events in patients with and without coronary artery disease (CAD) [2]. Moreover, CFR provides independent prognostic information in diabetic and nondiabetic patients with known or suspected CAD and negative dipyridamole stress echocardiography [3]. The prognostic impact of CFR on survival was found even in a general population with normal or near-tonormal coronary arteries [4].…”