Additional vitamin E required in milk replacer diets that contain canola oil

Sauer, Frank; Farnworth, E. R.; Bélanger, Jacqueline M.R.; Kramer, J. K. G.; Miller, R. B.; Yamashiro, S.

doi:10.1016/s0271-5317(96)00256-4

Cited by 9 publications

(8 citation statements)

References 22 publications

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“…Decreased platelet counts (Naito et al, 2000a), increased erythrocyte fragility, severe renal injury involving lesions in blood vessels (Miyazaki et al, 2000) and elevated blood pressure (Naito et al, 2000b) are associated with dietary canola oil. Similar anti-nutritional activities of canola oil have been observed in rats of other strains (Naito et al, 2000b), mice (Kameyama et al, 1996) and pigs (Sauer et al, 1997;Innis and Dyer, 1999). Although the survival-shortening factor in canola oil had been assumed to be phytosterols (Ratnayake et al, 2000b), the factor and the phytosterols have been partially separated by a CO 2 -supercritical fluid extraction method, indicating that a factor other than triacylglycerol and phytosterols is involved in the survival shortening (Tatematsu et al, 2004a;Ohara et al, 2006).…”

Section: Introductionsupporting

confidence: 53%

“…The unusual effects of canola and hydrogenated soybean oil may not be confined to SHRSP because the decreased platelet counts and unusual survival shortening effects of canola oil have also been observed in pigs (Sauer et al, 1997;Innis and Dyer, 1999). In boars, rapeseed meal caused degeneration and necrosis of the seminiferous epithelium, resulting in the atrophy of the seminiferous tubules, compared with soybean meal (Rotkiewicz et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…However, the unusual effects of canola and some other vegetable oils observed in rodents Innis and Dyer, 1999;Miyazaki et al, 2000;Tatematsu et al, 2004; and piglets (Sauer et al, 1997;Innis and Dyer, Statistical analyses were performed using one-way ANOVA, 7…”

Section: Discussionmentioning

confidence: 99%

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Testosterone-lowering activity of canola and hydrogenated soybean oil in the stroke-prone spontaneously hypertensive rat

et al. 2010

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-Canola and some other types of oil unusually shorten the survival of stroke-prone spontaneously hypertensive rats (SHRSP), compared with soybean oil, perilla oil and animal fats. Since differential effects of canola and soybean oil on steroid hormone metabolism were suggested by a preliminary DNA microarray analysis as a reason for this, the steroid hormone levels in the serum and tissues of SHR-SP fed different oils were investigated. The testosterone levels in the serum and the testes were found to be significantly lower in the canola oil group than in the soybean oil group, while no significant differences were detected in the corticosterone and estradiol levels in tissues. In a second experiment, it was found that hydrogenated soybean oil, with a survival-shortening activity comparable to that of canola oil, also decreased the testosterone level in testes to a similar degree. The testosterone-lowering activity of canola and hydrogenated soybean oil observed in SHRSP was considered in relation to other factors possibly affecting the physiology of SHRSP.

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Section: Introductionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

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Testosterone-lowering activity of canola and hydrogenated soybean oil in the stroke-prone spontaneously hypertensive rat

et al. 2010

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“…The vitamin E content was 150 IU/kg diet to avoid vitamin E deficiency in the canola oil-fed group (15). The dry-milk powders were stored at −20°C until used.…”

Section: Methodsmentioning

confidence: 99%

“…Diets were prepared to include 150 IU of vitamin E per kg diet to ensure that the canola oil-and HEAR oil-fed piglets had sufficient vitamin E, since we previously observed that milk-replacer diets containing canola oil required additional vitamin E (15). The vitamin E levels in liver and heart were found to be lower in the canola oil and the canola oil/cocoa butter mixture compared to soybean oil, but the differences were generally not significant (results published elsewhere, 24).…”

Section: Table 5 Fatty Acid Composition (Area %) Of Platelet Phospholmentioning

confidence: 99%

Hematological and lipid changes in newborn piglets fed milk‐replacer diets containing erucic acid

Kramer

Sauer

Farnworth

et al. 1998

Lipids

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Canola oil is not presently permitted in infant formulations in the United States because of lack of information concerning the effects of feeding canola oil to the newborn. We have previously reported a transient decrease in platelet counts and an increase in platelet size in newborn piglets fed canola oil for 4 wk, and have confirmed this in the present study. In canola oil-fed piglets, changes in platelet size and number were overcome by adding either long-chain saturated fatty acids from cocoa butter (16:0 and 18:0), or shorter-chain saturates from coconut oil (12:0 and 14:0). Feeding a high erucic acid rape-seed (HEAR) oil, with 20% 22:1n-9, led to an even greater platelet reduction and increased platelet size throughout the 4-wk trial. Bleeding times were longer in piglets fed canola oil or HEAR oil compared to sow-reared and soybean oil-fed piglets. There were no other diet-related changes. Diet-induced platelet changes were not related to platelet lipid class composition, but there were fatty acid changes. The incorporation of 22:1n-9 into platelet phospholipids of piglets fed canola oil was low (0.2-1.2%), and even for the HEAR oil group ranged from only 0.2% in phosphatidylinositol to 2.4% in phosphatidylserine. A much greater change was observed in the concentration of 24:1n-9 and in the 24:1n-9/24:0 ratio in platelet sphingomyelin (SM). The 24:1n-9 increased to 49% in the HEAR oil group compared to about 12% in animals fed the control diets (sow-reared piglets and soybean oil-fed group), while the 24:1n-9/24:0 ratio increased from about 1 to 12. Even feeding canola oil, prepared to contain 2% 22:1n-9, led to a marked increase in 24:1n-9 to 29% and had a 24:1n-9/24:0 ratio of 5. The canola oil/cocoa butter group, which also contained 2% 22:1n-9, showed a lower level of 24:1n-9 (20%) and the 24:1n-9/24:0 ratio (3) compared to the canola oil group. The results suggest that the diet-related platelet changes in newborn piglets may be related to an increase in 24:1n-9 in platelet SM, resulting from chain elongation of 22:1n-9. The inclusion of canola oil as the sole source of fat in the milk-replacer diets of newborn piglets resulted in significant platelet and lipid changes.

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Brassica napus

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2012

Edible Medicinal and Non-Medicinal Plants

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Additional vitamin E required in milk replacer diets that contain canola oil

Cited by 9 publications

References 22 publications

Testosterone-lowering activity of canola and hydrogenated soybean oil in the stroke-prone spontaneously hypertensive rat

Testosterone-lowering activity of canola and hydrogenated soybean oil in the stroke-prone spontaneously hypertensive rat

Hematological and lipid changes in newborn piglets fed milk‐replacer diets containing erucic acid

Brassica napus

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