Additive antidepressant-like effects of fasting with imipramine via modulation of 5-HT2 receptors in the mice

Li, Bingjin; Zhao, Jing; Lv, Jiayin; Tang, Furong; Liu, Lei; Sun, Zhen; Wang, Liang; Siwela, Sibongile P.; Wang, Yinuo; Song, Yunong; Manchishi, Stephen M.; Cui, Ranji

doi:10.1016/j.pnpbp.2013.08.015

Cited by 32 publications

(60 citation statements)

References 36 publications

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“…In this respect, a recent study has shown that 9 h fasting in mice leads to significant antidepressant effects [111]. Interestingly, additive effects were observed when the antidepressant drug imipramine was administered in conjunction with the fasting period.…”

Section: Intermittent Fasting: Effects Of Expanding Time Between Mmentioning

confidence: 99%

Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap

2014

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Dietary interventions have emerged as effective environmental inducers of brain plasticity. Among these dietary interventions, we here highlight the impact of caloric restriction (CR: a consistent reduction of total daily food intake), intermittent fasting (IF, every-other-day feeding), and diet supplementation with polyphenols and polyunsaturated fatty acids (PUFAs) on markers of brain plasticity in animal studies. Moreover, we also discuss epidemiological and intervention studies reporting the effects of CR, IF and dietary polyphenols and PUFAs on learning, memory, and mood. In particular, we evaluate the gap in mechanistic understanding between recent findings from animal studies and those human studies reporting that these dietary factors can benefit cognition, mood, and anxiety, aging, and Alzheimer's disease—with focus on the enhancement of structural and functional plasticity markers in the hippocampus, such as increased expression of neurotrophic factors, synaptic function and adult neurogenesis. Lastly, we discuss some of the obstacles to harnessing the promising effects of diet on brain plasticity in animal studies into effective recommendations and interventions to promote healthy brain function in humans. Together, these data reinforce the important translational concept that diet, a modifiable lifestyle factor, holds the ability to modulate brain health and function.

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Section: Intermittent Fasting: Effects Of Expanding Time Between Mmentioning

confidence: 99%

Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap

2014

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“…Pharmacological studies have shown that CRF1 receptor antagonist, 5-HT1 receptor agonist, and adrenoreceptor antagonist can decrease depression-like behaviors, indicating that endogenous systems of CRF and monoamines including 5-HT and NE in the brain contribute to development of depression [31-34]. Thus, it is not unexpected that normalization of these systems attenuates depression-like behaviors [35-37].…”

Section: Discussionmentioning

confidence: 99%

Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice

Park

Lim²,

Zhao

et al. 2015

BMC Complement Altern Med

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BackgroundPsychological stressors may cause affective disorders, such as depression and anxiety, by altering expressions of corticotropin releasing factor (CRF), serotonin (5-HT), and tyrosine hydroxylase (TH) in the brain. This study investigated the effects of essential oil from Asarum heterotropoides (EOAH) on depression-like behaviors and brain expressions of CRF, 5-HT, and TH in mice challenged with stress.MethodsMale ICR mice received fragrance inhalation of EOAH (0.25, 0.5, 1.0, and 2.0 g) for 3 h in the special cage capped with a filter paper before start of the forced swimming test (FST) and tail suspension test (TST). The duration of immobility was measured for the determination of depression-like behavior in the FST and TST. The selective serotonin reuptake inhibitor fluoxetine as positive control was administered at a dose of 15 mg/kg (i.p.) 30 min before start of behavioral testing. Immunoreactivities of CRF, 5-HT, and TH in the brain were also measured using separate groups of mice subjected to the FST.ResultsEOAH at higher doses (1.0 and 2.0 g) reduced immobility time in the FST and TST. In addition, EOAH at a dose of 1.0 g significantly reduced the expected increases in the expression of CRF positive neurons in the paraventricular nucleus and the expression of TH positive neurons in the locus coeruleus, and the expected decreases of the 5-HT positive neurons in the dorsal raphe nucleus.ConclusionThese results provide strong evidence that EOAH effectively inhibits depression-like behavioral responses, brain CRF and TH expression increases, and brain 5-HT expression decreases in mice challenged with stress.

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“…Ketanserin was administered 30 min after berberine administration in the berberine/ketanserin group. The dose levels of the berberine and ketanserine used were based on the previous reports 14, 42 .…”

Section: Methodsmentioning

confidence: 99%

“…After the membranes were washes using TBST buffer solution, the respective peroxidase-labeled secondary antibodies (anti-rabbit: 1:400; Protein Tech, #SA00001-2; anti-mouse: 1:5000; ZSBG-Bio, #ZB2305) were used for their incubation. Specific band densities were quantified using the Image J software, and the ratio of intensities of pCREB/CREB, peEF 2 /eEF 2 and BDNF/β-actin from the same homogenate were calculated 42 .…”

Section: Methodsmentioning

confidence: 99%

Berberine produces antidepressant-like effects in ovariectomized mice

Fan

et al. 2017

Sci Rep

Self Cite

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Berberine has been reports to have antidepressant-like effects. However, it is seldom known whether berberine produces antidepressant-like effects in ovariectomized mice, which exhibit depressive-like responses. To examine the antidepressant-like effects of berberine in ovariectomized mice, behavioral tests were conducted, including the forced swimming test and the open field test. To elucidate the mechanisms, levels of BDNF, phosphorylated CREB and phosphorylated eEF2 were analyzed by western blotting, and c-Fos induction was examined by immunohistochemistry. In the forced swimming test, berberine decreased the immobility time in a dose-dependent manner, reversing the depressive-like effect observed in ovariectomized mice, and this effect was blocked by the 5-HT2 antagonist ketanserin. In addition, western blotting indicated that BDNF and peEF2 in the hippocampus, but not pCREB/CREB in the frontal cortex, were affected by berberine treatment. Furthermore, immunohistochemistry demonstrated that the reduction in c-Fos induced by ovariectomy were greater after berberine treatment. Ketanserin also antagonized the effect of berberine on the c-Fos expression. Our findings suggest that berberine exerts antidepressant-like effects in ovariectomized mice, and 5-HT2 receptor activation may be partially related to the antidepressant-like effects of the berberine by BDNF-CREB and eEF2 pathways.

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Additive antidepressant-like effects of fasting with imipramine via modulation of 5-HT2 receptors in the mice

Cited by 32 publications

References 36 publications

Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap

Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap

Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice

Berberine produces antidepressant-like effects in ovariectomized mice

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