Additive manufacturing and technical strategies for improving outcomes in breast reconstructive surgery

Rocco, Nicola; Papallo, Ida; Nava, Maurizio; Catanuto, Giuseppe; Accurso, Antonello; Onofrio, Ilaria; Oliviero, Olimpia; Improta, Giovanni; Speranza, Domenico; Domingos, Marco; Russo, Teresa; Santis, Roberto De; Martorelli, Massimo; Gloria, Antonio

doi:10.21014/acta_imeko.v9i4.754

Cited by 36 publications

(5 citation statements)

References 33 publications

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“…Several strategies have become widespread to support healthcare managers in increasing knowledge from data. Health technology assessment (Improta et al, 2009;Improta et al, 2012), smart technologies (Apicella et al, 2021;Arpaia et al, 2020;Rocco et al, 2020;Angrisani et al, 2020;Bernasconi et al, 2020), specific care path (Improta et al, 2021;Improta et al, 2020), data analysis (Ponsiglione et al, 2022;Improta et al, 2014;Ponsiglione et al, 2021a;Cesarelli et al, 2012;Cortesi et al, 2019) and machine learning (Improta et al, 2022;Ponsiglione et al, 2021b) are just a few examples.…”

Section: Lean Application In Healthcarementioning

confidence: 99%

Lean Six Sigma to reduce the acute myocardial infarction mortality rate: a single center study

Rosa

Trunfio

Marolla

et al. 2023

TQM

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PurposeCardiovascular diseases are the leading cause of death worldwide. In Italy, acute myocardial infarction (AMI) is a major cause of hospitalization and healthcare costs. AMI is a myocardial necrosis event caused by an unstable ischemic syndrome. The Italian government has defined an indicator called “AMI: 30-day mortality” to assess the quality of the overall care pathway of the heart attacked patient. In order to guarantee high standards, all hospitals had to implement techniques to increase the quality of care pathway. The aim of the paper is to identify the root cause and understand the mortality rate for AMI and redesign the patient management process in order to improve it.Design/methodology/approachA Lean Six Sigma (LSS) approach was used in this study to analyze the patient flow in order to reduce 30-days mortality rate from AMI registered by Complex Operative Unit (COU) of Cardiology of an Italian hospital. Value stream mapping (VSM) and Ishikawa diagrams were implemented as tools of analysis.FindingsProcess improvement using LSS methodology made it possible to reduce the overall times from 115 minutes to 75 minutes, with a reduction of 35%. In addition, the corrective actions such as the activation of a post-discharge outpatient clinic and telephone contacts allowed the 30-day mortality rate to be lowered from 16% before the project to 8% after the project. In this way, the limit value set by the Italian government was reached.Research limitations/implicationsThe limitation of the study is that it is single-centered and was applied to a facility with a limited number of cases.Practical implicationsThe LSS approach has brought significant benefits to the process of managing patients with AMI. Corrective actions such as the activation of an effective shared protocol or telephone interview with checklist can become the gold standard in reducing mortality. The limitation of the study is that it is single-centered and was applied to a facility with a limited number of cases.Originality/valueLSS, applied for the first time to the management of cardiovascular diseases in Italy, is a methodology which has proved to be strategic for the improvement of healthcare process. The simple solutions implemented could serve as a guide for other hospitals to pursue the national AMI mortality target.

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Section: Lean Application In Healthcarementioning

confidence: 99%

Lean Six Sigma to reduce the acute myocardial infarction mortality rate: a single center study

Rosa

Trunfio

Marolla

et al. 2023

TQM

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“…68 Another interesting application of developing customized 3D scaffolds using poly(e-caprolatone) with tailored morphology (with a length of 7 mm, width of 7 mm and a height of 8 mm, a filament distance of 650 mm and different internal quadrangular, complex polygonal and triangular pore geometries, 0°/90°, 0°/ 60°/120°, and 0°/45°/90°/135°lay down patterns), based on 3D additive manufacturing has been described. 69 The variation in pore size geometries within a single scaffold is said to promote tissue regeneration by providing the required strength and flexibility. 70 3D structures with tailored architectures of varying lay-down patterns, pore geometries thereby aid in breast reconstructive surgery.…”

Section: Biomedical Applications Of Uv Based 3d Printed Biomaterialsmentioning

confidence: 99%

A review on fabrication of 3D printed biomaterials using optical methodologies for tissue engineering applications

John¹,

Antony

Whenish

et al. 2022

Proc Inst Mech Eng H

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Human body comprises of different internal and external biological components. Human organs tend to fail due to continuous or sudden stress which leads to deterioration, failure, and dislocation. The choice of selection and fabrication of materials for tissue engineering play a key role in terms of suitability, sensitivity, and functioning with other organs as a replacement for failed organs. The progressive improvement of the additive manufacturing (AM) approach in healthcare made it possible to print multi-material and customized complex/intricate geometries in a layer-by-layer fashion. The customized or patient-specific implant fabrication can be easily produced with a high success rate due to the development of AM technologies with tailorable properties. The structural behavior of 3D printed biomaterials is a crucial factor in tissue engineering as they affect the functionality of the implants. Various techniques have been developed in appraising the important features and the effects of the subsequent design of the biomaterial implants. The behavior of the AM built biomaterial implants can be understood visually by an imaging system with a high spatial and spectral resolution. This review intends to present an overview of various biomaterials used in implants, followed by a detailed description of optical 3D printing procedures and evaluation of the performance of 3D printed biomaterials using optical characterization.

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“…The researchers conducted preliminary mechanical and biological analyses to see how the lay-down pattern affected the performances of the fabricated devices. The results demonstrated that the constructions with a 0°/90° pattern gave a compressive modulus that was much higher than those obtained for the other types of scaffolds at a fixed filament diameter, filament spacing, and slice thickness [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in 3D Bio-Printing and Its Biomedical Applications

Assad

Assad²,

Kumar³

2023

Pharmaceutics

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The fast-developing field of 3D bio-printing has been extensively used to improve the usability and performance of scaffolds filled with cells. Over the last few decades, a variety of tissues and organs including skin, blood vessels, and hearts, etc., have all been produced in large quantities via 3D bio-printing. These tissues and organs are not only able to serve as building blocks for the ultimate goal of repair and regeneration, but they can also be utilized as in vitro models for pharmacokinetics, drug screening, and other purposes. To further 3D-printing uses in tissue engineering, research on novel, suitable biomaterials with quick cross-linking capabilities is a prerequisite. A wider variety of acceptable 3D-printed materials are still needed, as well as better printing resolution (particularly at the nanoscale range), speed, and biomaterial compatibility. The aim of this study is to provide expertise in the most prevalent and new biomaterials used in 3D bio-printing as well as an introduction to the associated approaches that are frequently considered by researchers. Furthermore, an effort has been made to convey the most pertinent implementations of 3D bio-printing processes, such as tissue regeneration, etc., by providing the most significant research together with a comprehensive list of material selection guidelines, constraints, and future prospects.

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Additive manufacturing and technical strategies for improving outcomes in breast reconstructive surgery

Cited by 36 publications

References 33 publications

Lean Six Sigma to reduce the acute myocardial infarction mortality rate: a single center study

Lean Six Sigma to reduce the acute myocardial infarction mortality rate: a single center study

A review on fabrication of 3D printed biomaterials using optical methodologies for tissue engineering applications

Recent Developments in 3D Bio-Printing and Its Biomedical Applications

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