Additive Manufacturing Technologies for Drug Delivery Applications

Mohammed, Abdullah; ElShaer, Amr; Sareh, Pooya; El‐Sayed, M. A.; Hassanin, Hany

doi:10.1016/j.ijpharm.2020.119245

Cited by 90 publications

(56 citation statements)

References 143 publications

(158 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3D printing has advanced as a technology that uses materials like polymers, metals, and ceramics and builds objects layer by layer with broad applications and different geometries. [ 23 ] Different 3D printing technologies are currently available for several applications. These technologies can be classified in seven categories: Material jetting, material extrusion, vat photopolymerization, powder bed fusion, binder jetting, sheet lamination, and directed energy deposition.…”

Section: D Printing Techniquesmentioning

confidence: 99%

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

Santos

Oliveira

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

3D printing and nanotechnology have been two important tools in the development of therapeutic approaches for personalized medicine. More recently, their alliance has been improved in an effort to build innovative, versatile, multifunctional, and/or smart medical and pharmaceutical products. Therefore, an extensive review about scientific studies that ally 3D printing and nanomaterials in the development of new approaches for pharmaceutical and medical applications for the treatment and prevention of diseases is presented here. The articles are classified into five categories according to their main application: Cell growth and tissue engineering, antimicrobial, drug delivery, stimulus‐response, and theranostics. Semisolid extrusion, inorganic nanoparticles, and cell growth and tissue engineering are the most reported 3D printing technique, type of nanomaterial, and application, respectively. The increase in papers dedicated to these areas is also notable, especially in the 2019 and 2020, when semisolid extrusion became the most used technique, overcoming fused deposition modelling. In fact, this review highlights that the possibility of an alliance between 3D printing and nanotechnology for the production of multiscale materials is undoubtedly a great opportunity for knowledge and innovation in the pharmaceutical and medical area.

show abstract

Section: D Printing Techniquesmentioning

confidence: 99%

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

Santos

Oliveira

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…Year after year, 3D printing provides ever more applications in the healthcare area serving to rescue and improve lives in ways never conceived up to now with COVID-19. In the pharmaceutical and medical industry, the focus is on improving product quality and reducing time to market for new products [ 14 ]. At all stages of product development, 3D printing improves and accelerates decision making upstream, the use of a 3D printer makes it possible to validate an idea, then a design and ergonomics based on iterations, and finally to test the product’s functionalities.…”

Section: Am Technology Against Covid-19mentioning

confidence: 99%

3D Printing to Support the Shortage in Personal Protective Equipment Caused by COVID-19 Pandemic

et al. 2020

View full text Add to dashboard Cite

Currently, the emergence of a novel human coronavirus disease, named COVID-19, has become a great global public health concern causing severe respiratory tract infections in humans. Yet, there is no specific vaccine or treatment for this COVID-19 where anti-disease measures rely on preventing or slowing the transmission of infection from one person to another. In particularly, there is a growing effort to prevent or reduce transmission to frontline healthcare professionals. However, it is becoming an increasingly international concern respecting the shortage in the supply chain of critical single-use personal protective equipment (PPE). To that scope, we aim in the present work to provide a comprehensive overview of the latest 3D printing efforts against COVID-19, including professional additive manufacturing (AM) providers, makers and designers in the 3D printing community. Through this review paper, the response to several questions and inquiries regarding the following issues are addressed: technical factors connected with AM processes; recommendations for testing and characterizing medical devices that additively manufactured; AM materials that can be used for medical devices; biological concerns of final 3D printed medical parts, comprising biocompatibility, cleaning and sterility; and limitations of AM technology.

show abstract

“…In fact, additive manufacturing allows so many new possibilities and with so much impact that they make it possible to speak of a new paradigm in terms of mass customization [ 47 ]. A reality that opens many lines of application and business, and that in fields such as medicine and pharmaceutics, where additive manufacturing is already being widely applied [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ], can be especially beneficial by offering personalized solutions tailored to patients.…”

Section: Initial Considerations and Main Synergies Of The Technolomentioning

confidence: 99%

Integration of Additive Manufacturing, Parametric Design, and Optimization of Parts Obtained by Fused Deposition Modeling (FDM). A Methodological Approach

2020

View full text Add to dashboard Cite

The use of current computer tools in both manufacturing and design stages breaks with the traditional conception of productive process, including successive stages of projection, representation, and manufacturing. Designs can be programmed as problems to be solved by using computational tools based on complex algorithms to optimize and produce more effective solutions. Additive manufacturing technologies enhance these possibilities by providing great geometric freedom to the materialization phase. This work presents a design methodology for the optimization of parts produced by additive manufacturing and explores the synergies between additive manufacturing, parametric design, and optimization processes to guide their integration into the proposed methodology. By using Grasshopper, a visual programming application, a continuous data flow for parts optimization is defined. Parametric design tools support the structural optimization of the general geometry, the infill, and the shell structure to obtain lightweight designs. Thus, the final shapes are obtained as a result of the optimization process which starts from basic geometries, not from an initial design. The infill does not correspond to pre-established patterns, and its elements are sized in a non-uniform manner throughout the piece to respond to different local loads. Mass customization and Fused Deposition Modeling (FDM) systems represent contexts of special potential for this methodology.

show abstract

Additive Manufacturing Technologies for Drug Delivery Applications

Cited by 90 publications

References 143 publications

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

3D Printing to Support the Shortage in Personal Protective Equipment Caused by COVID-19 Pandemic

Integration of Additive Manufacturing, Parametric Design, and Optimization of Parts Obtained by Fused Deposition Modeling (FDM). A Methodological Approach

Contact Info

Product

Resources

About