Addressing the Barriers to Cervical Cancer Prevention Among Hispanic Women

Alligood-Percoco, Natasha R.; Kesterson, Joshua

doi:10.1007/s40615-015-0166-z

Cited by 1 publication

(1 citation statement)

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“…HPV-16 and − 18 are the most significant, followed by 33,35,39,45,51,52,56,58,59, and 68 [2,3]; however, type-specific frequencies vary according to the population type and geographical region analyzed [4]. Additionally, cancer development is multifactorial, influenced by various risk factors associated with sexual behavior and genetic, cultural, and social characteristics of the studied communities [5], and intrinsic characteristics of the viruses present in the infections [6].…”

Section: Introductionmentioning

confidence: 99%

High frequency of alpha7-HPV in Colombian Caribbean coast women: cervical cancer screening analysis

Arteaga-Pautt,

Bru-Cordero,

Ricardo-Caldera

et al. 2024

BMC Infect Dis

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SUMMARY Background Cervical cancer (CC) is a significant global public health concern, particularly in developing countries such as Colombia. The main risk factor involves high-risk HPV types (HR-HPV) infection, coupled with population-specific variables. The Caribbean region in Colombia lacks research on HR-HPV-type frequencies. Therefore, this study aims to establish the prevalence of type-specific HR-HPV and its association with sociodemographic factors among women undergoing cervical cytology screening. Methods A cross-sectional study involving voluntary women who provided informed consent and completed a questionnaire capturing sociodemographic, clinical, and sexual behavior information was conducted. All participants underwent cervical cytology and molecular analysis. Generic HPV detection employed three simultaneous PCRs (GP5+/6+, MY09/11, and PU1R/2 M), and positive samples were genotyped using the Optiplex HPV Genotyping kit. The analysis encompassed the 12 types of high-risk HPV (HR-HPV-16,-18,-31,-33,-35,-39,-45,-51,-52,-56,-58, and − 59). Frequencies were reported based on geographic subregions within the Córdoba department, and disparities were made between single and multiple infections. Sociodemographic and clinical variables were subjected to ordinal logistic regression, with statistical significance at a p-value < 0.05. The statistical analyses utilized STATA 14® and R-Core Team-software. Results We included 450 women, mean age 40 (SD$$\pm$$11.44). PCR analysis revealed 43% HPV-positive (n=192). GP5+/6+ detected the most positives at 26% (n=119), followed by PU1R/2 M at 22% (n = 100) and MY09/11 at 15% (n=69). Multiple infections occurred in 87.3% (n=142), primarily 2 to 4 types (47.37%, n=90). Dominant types were HPV-18 (15.6%, n=61), HPV-16 (14.9%, n=58), HPV-31 (13.0%, n = 51), and HPV-45 (11.5%, n=45). Logistic regression identified age above 60 as a risk for concurrent multiple types (OR=6.10; 95% CI 1.18–31.63). Menopause was protective (OR=0.31; 95% CI 0.11–0.89). Conclusions Our study reveals a notable prevalence of multiple (2–4) high-risk HPV infections among adult women engaged in CC detection initiatives. Predominantly, α7 species constitute the prevalent HR-viral types, with the Medio Sinú subregion showing elevated prevalence. Menopausal status confers protection against diverse HR-HPV infections. Nevertheless, advancing age, particularly beyond 60 years, is linked to an increased susceptibility to simultaneous infections by multiple HPV-types.

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