Adenocarcinoma Occurring in a Hyperplastic (Metaplastic) Polyp of the Colon

Franzin, G.; Novelli, Paula Cristina Steffen

doi:10.1055/s-2007-1021569

Cited by 61 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The size of the polypectomised specimens did not diVer significantly between serrated adenomas and traditional adenomas, at 12 (6) mm v 13 (3) mm. There were four serrated adenomas which contained areas of high grade dysplasia (figs 2 and 3).…”

Section: Dysplasiamentioning

confidence: 77%

“…The presence of neoplastic change within hyperplastic polyps or in neoplasms mimicking hyperplasia in the general population, [6][7][8][9] in metaplastic polyposis, 15 16 or even in hereditary non-polyposis colorectal cancer 5 has raised the possibility that hyperplastic polyps may be another precursor of human colorectal cancer. The serrated adenoma can be regarded as a specific lesion which might explain the occurrence of neoplasia within hyperplastic polyps.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] There have been reports, however, of cases of hyperplastic polyps associated with adenomatous or cancerous areas. [5][6][7][8] In 1990, Longacre and Fenoglio-Preiser 9 described a new category of colorectal neoplasia with a serrated glandular configuration, and pathologists now refer to such lesions as "serrated adenomas." While there has been a subsequent description of the histopathological features of serrated adenoma, 10 the clinical significance and treatment implications of these lesions have not been examined.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma.

et al. 1999

View full text Add to dashboard Cite

Aim-Serrated adenoma is a recently described category of colorectal adenoma. The aim of this study was to determine whether serrated adenomas have clinicopathological findings distinct from "traditional" adenoma. Methods-Colonoscopy records for 1995-1998 were reviewed, and all traditional adenomas and serrated adenomas identified. Tumour site and endoscopic configuration were compared between the two types of adenoma. In polypectomised lesions, size and grade of dysplasia were compared between the two groups. Results-There were 3305 traditional adenomas and 43 serrated adenomas. Serrated adenomas were more often found in the rectosigmoid colon than the traditional adenomas (67.5% v 41.2%, p = 0.0008). Polypectomy was more often done for serrated adenomas (27 of 43 lesions, 62.8%) than for traditional adenomas (626 of 3305 lesions, 18.9%, p < 0.0001). Size (mean (SD) maximum dimension, 12 (6) mm v 13 (3) mm) and incidence of high grade dysplasia (14.8% v 13.6%) in endoscopically removed specimens were not diVerent between the two types. Conclusions-The therapeutic judgement applied to the management of traditional adenoma seems to be appropriate for serrated adenoma. (J Clin Pathol 1999;52:513-516) Keywords: colon; adenoma; serrated adenoma; colonoscopy Hyperplastic (metaplastic) polyps of the colorectum have been regarded as benign, nonneoplastic protrusions. Discussion of their clinical significance has mainly focused on whether the presence of this type of lesion is predictive of the simultaneous or metachronous occurrence of colorectal neoplasia.

show abstract

Section: Dysplasiamentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma.

et al. 1999

View full text Add to dashboard Cite

show abstract

“…One carcinoma reported in an individual with HPS was shown to have arisen in an otherwise typical tubular adenoma. 16 Furthermore, although cases of adenocarcinoma have been reported as actually arising within sporadic hyperplastic polyps and serrated adenomas, 17,18 to date this phenomenon has not been reported in individuals with the HPS syndrome.…”

mentioning

confidence: 99%

Colorectal Carcinomas Arising in the Hyperplastic Polyposis Syndrome Progress through the Chromosomal Instability Pathway

Hawkins

Gorman

Tomlinson³

et al. 2000

The American Journal of Pathology

View full text Add to dashboard Cite

The hyperplastic polyposis syndrome is characterized by the presence within the colon of multiple large hyperplastic polyps. We describe a case of hyperplastic polyposis syndrome associated with two synchronous carcinomas , one of which arises within a pre-existing hyperplastic lesion. Comparative genomic hybridization was used to determine genetic changes in both carcinomas and several associated hyperplastic lesions. Microsatellite analysis at five loci was performed on carcinomas and representative hyperplastic polyps , and p53 status was analyzed by immunohistochemistry. Both carcinomas showed multiple genetic aberrations , including high level gains of 8q and 13q , and loss of 5q. These changes were not seen in the hyperplastic polyps. Microsatellite instability was not seen in the carcinomas , four separate hyperplastic polyps , the hyperplastic polyp with mild adenomatous change associated with the carcinoma , or a separate serrated adenoma. Allelic imbalance in the cancers at D5S346 and D17S938 suggested allelic loss of both p53 and APC , as well as at the loci D13S263 , D13S174 , D13S159 , and D18S49. An early invasive carcinoma in one hyperplastic polyp stained for p53 protein , but the associated hyperplastic polyp was negative. In this case , neoplastic progression followed the typical genetic pathway of common colorectal carcinoma and occurred synchronously with mutation of p53. (Am J Pathol 2000, 157:385-392)

show abstract

“…On the other hand, larger hyperplastic polyps carry an increased potential for dysplastic change. 1,2 We have shown previously that a mutation of the K-ras gene was detectable in approximately one-half of the hyperplastic polyps we studied. 3 Another study has suggested that hyperplastic polyps may show clonal genetic alterations and microsatellite instability.…”

mentioning

confidence: 91%

Adenocarcinoma in Solitary Large Hyperplastic Polyp Diagnosed by Magnifying Colonoscope

Tonooka

Sano

Fujii

et al. 2002

Diseases of the Colon &Amp; Rectum

View full text Add to dashboard Cite

We report a case of carcinoma in a hyperplastic polyp in a 78-year-old female that was diagnosed before resection using a magnifying colonoscope. The patient presented with fecal occult blood and underwent total colonoscopy, which revealed a 12-mm sessile polyp in the cecum. When seen in magnified view, an irregularly shaped pit was evident at the center of the polyp that was distinct from the asteroid-type pits observed over most of the lesion. We diagnosed this lesion as a hyperplastic polyp with a carcinoma component. The patient underwent endoscopic mucosal resection, and histologic section revealed a well-differentiated intramucosal adenocarcinoma in the hyperplastic polyp. Hyperplastic polyps of the colon are regarded as benign, nonneoplastic lesions. Few have reported carcinomas in or with hyperplastic polyps, and most of those were diagnosed after resection and histologic investigation. The literature suggests a precise observation and consideration of resection for large solitary hyperplastic polyps in the right side of the colon, because the risk of malignancy is high. Magnifying colonoscopy is helpful for observing the surface in detail and for correctly diagnosing and managing the lesion.

show abstract

Adenocarcinoma Occurring in a Hyperplastic (Metaplastic) Polyp of the Colon

Cited by 61 publications

References 0 publications

Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma.

Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma.

Colorectal Carcinomas Arising in the Hyperplastic Polyposis Syndrome Progress through the Chromosomal Instability Pathway

Adenocarcinoma in Solitary Large Hyperplastic Polyp Diagnosed by Magnifying Colonoscope

Contact Info

Product

Resources

About