Adenoid cystic carcinoma of the breast, 20 years of experience in a single center with review of literature

Treitl, Daniela; Radkani, Pejman; Rizer, Magda; Hussein, Siba El; Paramo, Juan C.; Mesko, Thomas W.

doi:10.1007/s12282-017-0780-1

Cited by 50 publications

(61 citation statements)

References 34 publications

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“…However, it is a tumor with a good overall prognosis, with 10-year survival rates close to 90%. Only 2% of patients present metastatic disease at diagnosis and the risk of local recurrence is less than 20% [1,9].…”

Section: Discussionmentioning

confidence: 99%

“…The treatment consists of the excision of the piece with a wide safety margin. The use of adjuvant therapy is controversial, with variable opinions on the subject; however, it has been seen that none of the treatments, chemotherapy, radiotherapy or hormone therapy, modify long-term survival [1,6].…”

Section: Introductionmentioning

confidence: 99%

“…In our case, the patient was 34 years old, and had no personal or family history of breast pathology or previous radiation; which makes the case even more exceptional. Given the infrequency of this tumor, there is no consensus on its diagnosis and clinical management [1,9]. Fine needle aspiration, or vacuum needle aspiration would be the techniques of choice for histological diagnosis; although in some cases, such as ours, the result is inconclusive and an excision-biopsy is required for correct typing.…”

Section: Introductionmentioning

confidence: 99%

“…Case Report Breast ultrasound. An irregular isoechogenic nodule suggestive of malignancy is observed.Adenoid cystic carcinoma of the breast is an extremely rare malignant tumour, accounting for 0.1% of malignant tumours of the breast according to the series[1]. This type of tumor is characteristic of the salivary glands, but can be found in other locations such as the lung, breast or prostate.…”

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confidence: 99%

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Adenoid Cystic Carcinoma (ACC) of the Breast: Unusual Breast Pathology in Young Women

Patricia¹,

Maite²,

Manuel³

et al. 2020

Act Sci wom hea

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Introduction: Adenoid cystic breast carcinoma is a tumour of extremely rare malignant behavior, belonging to the group of triple negative breast tumors but, unlike these, has a favorable prognosis with high survival if the diagnosis and management are appropriate [1,7,9]. Presentation of Case: A 34 year old female patient presented symptom is a well-circumscribed palpable mass in the right breast with recurrent breast pain that not improve with analgesic or progestin gel. Excision biopsy of a lump in the upper outer quadrant revealed adenoid cystic carcinoma. A right sided lumpectomy was performed, with sentinel node biopsy. Histopathology revealed a fibroadenoma accounting for one mass and adenoid cystic carcinoma in another, confirmed on Periodic acid Schiff (PAS) staining, with a very closely margin. A second lumpectomy was performed with focal adenoid cystic carcinoma. Finally a right side modified radical mastectomy (MRM) was performed. The sentinel node biopsy was negative. There was no evidence of recurrence or distant spread at follow-up 12 months postoperatively. Discussion: Adenoid cystic carcinoma of the breast is a rare tumor, of which very few cases have been described in the literature and which lacks in-depth studies on its diagnosis and management due to its rarity [1,2]. Nowadays, its diagnosis is based on biopsy excision and anatomopathological study. And the management, like the Basal_Like tumors of the breast, is based on surgical excision with a wide margin of safety. However, unlike these, axillary nodal study is not justified, and the use of posterior adjuvant is controversial with various opinions in this regard [1,3].

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Adenoid Cystic Carcinoma (ACC) of the Breast: Unusual Breast Pathology in Young Women

Patricia¹,

Maite²,

Manuel³

et al. 2020

Act Sci wom hea

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“…It typically presents in Caucasian women in their 6–7th decade as a palpable and often tender mass. It is usually a “triple negative” (ER, PR, and HER-2) breast cancer, precluding hormonally-targeted therapy [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Adenoid cystic carcinoma of the breast - Discordant size on imaging and pathology: A case report and review of literature

Agafonoff

Sobolewski

Braverman

2019

Annals of Medicine and Surgery

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Introduction Adenoid cystic carcinoma (ACC) is an uncommon tumour of the breast. It is known for its rare lymph node involvement and distant metastasis. A triple-negative breast cancer that has a favorable prognosis compared to other triple negative ductal carcinomas, it accounts for approximately 0.1–1% of all breast cancers. Presentation of case We report a case of a 69-year-old female with a palpable left breast mass who underwent multiple imaging modalities with significant size variance between the studies. Breast conserving therapy (BCT) was performed with axillary sentinel lymph node biopsy (SLNB) followed by radiation therapy (RT). Pathological examination confirmed the tumour as ACC. Discussion ACC, known as an persistent if low-grade malignant tumour of salivary gland, is considered to have low-malignant potential in the breast. It is a very rare subtype and from this scant data, there is minimal mention about size discrepancy between imaging modalities such as ultrasound and MRI. No consistent MRI features have been demonstrated, with the exception of T2 hyperintensity in larger lesions and T2 iso-intensity in smaller lesions. Ultrasound demonstrates primarily a hypoechoic or heterogenous mass with minimum vascularity, consistent with our radiographic findings. Conclusion ACC is a rare entity in breast cancer pathology. Its size can be highly variable as measured by various radiographic modalities, and final Pathology from the surgical specimen is, as always, required for an accurate tumoral diameter. With that caveat, careful utilization of pre-operative imaging modalities is critical in pre-surgical planning to choose the appropriate surgery.

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Biomarkers in Breast Carcinomas

Şahi̇n

Erdoğdu

Durak

et al. 2022

Biomarkers in Carcinoma of Unknown Primary

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Adenoid cystic carcinoma of the breast, 20 years of experience in a single center with review of literature

Cited by 50 publications

References 34 publications

Adenoid Cystic Carcinoma (ACC) of the Breast: Unusual Breast Pathology in Young Women

Adenoid Cystic Carcinoma (ACC) of the Breast: Unusual Breast Pathology in Young Women

Adenoid cystic carcinoma of the breast - Discordant size on imaging and pathology: A case report and review of literature

Biomarkers in Breast Carcinomas

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