Adenoma Detection before and after the age of 50: a retrospective analysis of Lebanese outpatients

Abstract

Background and aimColorectal cancer (CRC) has an increased impact on the Lebanese population’s morbidity and mortality. This study evaluated the situation of adenoma detection in an outpatient clinic in Lebanon.Patients and methods918 patients underwent colonoscopy over a period of 24 months by a qualified physician. Biopsy results were divided into normal versus abnormal colonic tissue, which was further subdivided into number of polyps and cancer.ResultsOut of 918 individuals included, 82 cases of Crohn’s colitis (8.93%) and 22 cases of ulcerative colitis (2.39%) were identified. A total of 42 cases of CRC (4.58%) and 188 cases of adenomatous polyps (20.48%) were identified. The data show that age >50 years and male gender significantly correlate with increased incidence of precancerous and cancerous polyps. Further exploring the results by age groups and gender, detection of adenomatous polyps in women aged 40–49 (8.33%) was significantly different from their female counterparts aged ≥50 years old (25.26%) (p<0.01). However, no statistical difference between detection of adenomas was found between men aged 40–49 (33.33%) and their male counterparts aged ≥50 years old (37.5%) (p=0.6).ConclusionWithin the limitations of this study, the incidence of CRC and adenomatous polyps falls in the high range compared with international studies. Furthermore, symptomatic male patients aged 40–49 appear to exhibit detection rates of adenomas similar to their counterparts aged ≥50 years old. Subjects younger than 50 years underwent diagnostic rather than screening colonoscopy, which introduces some selection bias. Nevertheless, these findings can serve as a basis for further studies.

A Noninvasive Risk Stratification Tool Build Using an Artificial Intelligence Approach for Colorectal Polyps Based on Annual Checkup Data

“…Regarding age, many studies have reported the association between age and colorectal polyps [ 29 , 30 ], suggesting that CRC screening should be performed around the age of 50–60 years in the general population owing to >80% of CRCs being diagnosed over the age of 60 years, which is consistent with our results [ 31 , 32 , 33 , 34 ].…”

Characteristics of adenomatous colorectal polyps among a Saudi population

“… 28 Similarly, an increasing incidence of CRC and adenomatous polyps in younger age groups has been reported in international studies. 29 , 30 , 31 As with other studies, we found no association between gender and adenomatous polyps. 14 , 16 …”

Systematic Review of Prevalence, Risk Factors, and Risk for Metachronous Advanced Neoplasia in Patients With Young-Onset Colorectal Adenoma

“…20-26, 28-32, 34, 35, 41-43, 45, 46 . Of the 19 studies of patients undergoing colonoscopy, 7 studies were performed on symptomatic patients alone 20,21,23,30,32,41,43 , 6 on asymptomatic patients 22,28,31,34,43,47 , and 6 did not specify whether patients were symptomatic or not 24,26,29,35,42,45 . The time period for assessment of our outcome data ranged from 1972 to 2017, with 19 of them conducted in patients undergoing colonoscopy after the year 1995, 3 studies prior to 1995, and 2 that began prior to 1995, but continued past this time.…”