Adenosine A 2A  receptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdala

López-Cruz, Laura; Carbó-Gas, Maria; Pardo, Marta; Bayarri, Pilar; Valverde, Olga; Ledent, Catherine; Salamone, John D.; Correa, Mercè

doi:10.1016/j.bbr.2016.12.020

Cited by 45 publications

(33 citation statements)

References 59 publications

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“…In one of them, sucrose pellets (TestDiet TM , 50% sucrose, 45 mg each) were available; in another arm, there was an RW; and in the third arm, there was a hole with a cotton ball socked with a fruit odor (based on López-Cruz et al, 2018). This concentration of sucrose in the pellets was selected after piloting different concentrations (i.e., 100% sucrose pellets generate avoidance), and the nonsocial odor used for the present studies (strawberry) was the one that generated more exploration among nonsocial odors in previous studies (López-Cruz et al, 2017). In general, mice were allowed to freely explore and interact with the stimulus during 15-min sessions, once a day, 5 days a week.…”

Section: T-maze Rw-sucrose-odor Choice Taskmentioning

confidence: 99%

Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia

Carratalá-Ros

López-Cruz

Miguel

et al. 2020

Front. Behav. Neurosci.

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Physical activities can have intrinsic motivational or reinforcing properties. The choice to engage in voluntary physical activity is undertaken in relation to the selection of other alternatives, such as sedentary behaviors, drugs, or food intake. The mesolimbic dopamine (DA) system plays a critical role in behavioral activation or exertion of effort, and DA antagonism or depletion induces anergia in effort-based decision-making tasks. However, little is known about the neural mechanisms underlying the decisionmaking processes that establish preferences for sedentary vs. activity-based reinforcers. In the present work with male CD1 mice, we evaluated the effect of tetrabenazine (TBZ), a DA-depleting agent, on a three-choice T-maze task developed to assess preference between reinforcers with different behavioral activation requirements and sensory properties [i.e., a running wheel (RW) vs. sweet pellets or a neutral nonsocial odor]. We also studied the effects of TBZ on the forced swim test (FST), which measures climbing and swimming in a stressful setting, and on anxiety tests [dark-light (DL) box and elevated plus maze (EPM)]. In the three-choice task, TBZ reduced time running in the wheel but increased time spent consuming sucrose, thus indicating reduced activation but relatively intact sucrose reinforcement. The effect of TBZ was not mimicked by motivational manipulations that change the value of the reinforcers, such as making the RW aversive or harder to move, food-restricting the animals, inducing a binge-like eating pattern, or introducing social odors. In the FST, TBZ decreased time climbing (most active behavior) and increased immobility but did not affect anxiety in the DL or EPM. These results indicate that the three-choice T-maze task could be useful for assessing DA modulation of preferences for exercise based on activation and effort requirements, differentiating those effects from changes in preference produced by altering physical requirements, food restriction state, and stress during testing.

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Section: T-maze Rw-sucrose-odor Choice Taskmentioning

confidence: 99%

Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia

Carratalá-Ros

López-Cruz

Miguel

et al. 2020

Front. Behav. Neurosci.

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“…The effects of A 2A receptors in anxiety in rodents have been investigated in some detail: A 2A receptor knock‐out mice exhibit not only increased anxiety‐like behavior but also increased c‐Fos immunoreactivity in the anterior cingulate cortex and the amygdala as compared to wild‐type mice (Lopez‐Cruz et al, ). However, the effects of A 2A receptors on anxiety‐like behavior in rodents are variable and highly dependent on the brain region.…”

Section: Role Of Adenosine A1 and A2a Receptors In Anxiety Disordersmentioning

confidence: 99%

The role of adenosine receptors in mood and anxiety disorders

Calker

Biber

Domschke

et al. 2019

Journal of Neurochemistry

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Adenosine receptor subtypes, first described 40 years ago, are known to regulate diverse biological functions and have a role in various conditions, such as cerebral and cardiac ischemia, immune and inflammatory disorders and cancer. In the brain, they limit potentially dangerous over excitation, but also regulate mechanisms essential in sleep and psychiatric disorders. In this review, we discuss the role of adenosine receptors in mood and anxiety disorders. Activation of A 2A receptors is associated with increased depression-like symptoms, while increased A 1 receptors signaling elicits rapid antidepressant effects. Indeed, several lines of evidence demonstrate that the therapeutic effects of different non-pharmacological treatments of depression, like sleep deprivation and electroconvulsive therapy are mediated by A 1 receptor up-regulation or activation. In addition, A 1 receptors may also play a role in the antidepressant effects of transcranial direct current stimulation and deep brain stimulation. As a potential downstream mechanism, which facilitates the antidepressant effects of A 1 receptors, we propose a crosstalk between adenosinergic and glutamatergic systems mediated via synaptic plasticity protein Homer1a and a-amino-3hydroxy-5-methyl-4-isoxazolepropionic acid receptors. Moreover, adenosine receptors are also involved in the control of circadian rhythms, sleep homeostasis and some neuroimmunological mechanisms, all of them implicated in mood regulation. Antagonists of adenosine receptors such as caffeine have general anxiogenic effects. In particular, A 2A receptors appear to have an important role in the pathophysiology of anxiety disorders. Taken together, the results discussed here indicate that the adenosinergic system is involved in both the etiology and the treatment of mood and anxiety disorders.

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“…In addition, A1AR can facilitate phospholipase C (PLC) activity through the activation of the Gq protein. ARs are known to be involved in the mechanisms underlying different forms of normal and pathological behavior, including social behavior and anxiety [ 113 , 114 ], avoidance learning [ 115 ], mood and memory dysfunction triggered by chronic stress [ 116 ], and cognitive impairment [ 117 ].…”

Section: Palmitoylation Of G Protein-coupled Receptors (Gpcrs)mentioning

confidence: 99%

Palmitoylation as a Functional Regulator of Neurotransmitter Receptors

Науменко

Ponimaskin

2018

Neural Plasticity

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The majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions. One of these modifications is a covalent attachment of a 16-C palmitic acid to one or more cysteine residues (S-palmitoylation) within the target protein. Palmitoylation is a reversible modification, and repeated cycles of palmitoylation/depalmitoylation might be critically involved in the regulation of multiple signaling processes. Palmitoylation also represents a common posttranslational modification of the neurotransmitter receptors, including G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LICs). From the functional point of view, palmitoylation affects a wide span of neurotransmitter receptors activities including their trafficking, sorting, stability, residence lifetime at the cell surface, endocytosis, recycling, and synaptic clustering. This review summarizes the current knowledge on the palmitoylation of neurotransmitter receptors and its role in the regulation of receptors functions as well as in the control of different kinds of physiological and pathological behavior.

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Adenosine A 2A receptor deletion affects social behaviors and anxiety in mice: Involvement of anterior cingulate cortex and amygdala

Cited by 45 publications

References 59 publications

Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia

Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia

The role of adenosine receptors in mood and anxiety disorders

Palmitoylation as a Functional Regulator of Neurotransmitter Receptors

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