Adenosine - a mediator with multisystemic effects (or a hormone?)

Lazurova, Zora; Mitro, Peter

doi:10.36290/vnl.2017.122

Vnitř Lék

2017

DOI: 10.36290/vnl.2017.122

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Adenosine - a mediator with multisystemic effects (or a hormone?)

Zora Lazurova¹,

Peter Mitro²

Abstract: Adenozín bol objavený v 20. rokoch minulého storočia ako látka s významným vazodilatačným efektom, až v 80. rokoch 20. storočia sa zistil jeho regulačný efekt na úrovni viacerých systémov organizmu. Spočiatku mu boli pripisované iba funkcie neurotransmitera autonómneho nervového systému, avšak stále viac štúdií dokazuje omnoho širšie spektrum jeho účinkov. V poslednom čase sa začal používať termín tzv. adenozínergický systém [1]. Fyziológia a metabolizmusAdenozín je látka s nukleozidovou štruktúrou molekuly s … Show more

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An integrated metabolomic strategy for the characterization of the effects of Chinese yam and its three active components on septic cardiomyopathy

Zhou

Zeng

et al. 2018

Food Funct.

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Chinese yam (CY), used as both a traditional Chinese medicine and a nutritious food, is an excellent candidate for treating septic cardiomyopathy (SCM). Adenosine, arbutin and allantoin are the major active components in the aqueous extract of CY. The aim of the present study was to interpret the roles of CY, adenosine, arbutin and allantoin in SCM treatment. Firstly, significant physiological indexes were examined to assess the model and treatment effects of CY, adenosine, arbutin and allantoin. Then, a metabolomic approach was utilized to reveal the metabolic disorders in SCM concerning the intervention of CY/adenosine/arbutin/allantoin. The integrated results demonstrated that adenosine, arbutin and allantoin are responsible for the efficacy of CY on SCM treatment by regulating amino acid, arachidonic acid, sphingolipid, glycerophospholipid and glycol metabolism. Moreover, adenosine and/or arbutin could be used as a substitute for CY in treating SCM, and allantoin efficacy was slightly weaker. This integrated metabolomic approach performed excellently in understanding the herbal function and the roles of its components.

show abstract

An integrated metabolomic strategy for the characterization of the effects of Chinese yam and its three active components on septic cardiomyopathy

Zhou

Zeng

et al. 2018

Food Funct.

View full text Add to dashboard Cite

show abstract

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Adenosine - a mediator with multisystemic effects (or a hormone?)

Cited by 1 publication

References 31 publications

An integrated metabolomic strategy for the characterization of the effects of Chinese yam and its three active components on septic cardiomyopathy

An integrated metabolomic strategy for the characterization of the effects of Chinese yam and its three active components on septic cardiomyopathy

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