1996
DOI: 10.1016/s0014-2999(96)00665-6
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Adenosine A2A receptors modulate the binding characteristics of dopamine D2 receptors in stably cotransfected fibroblast cells

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Cited by 93 publications
(66 citation statements)
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“…This effect was originally observed in rat striatal membranes (Ferré et al, 1991b), and subsequently also documented upon heterologous expression of the receptors in fibroblast cell lines (Ltk-murine fibroblasts in Dasgupta et al, 1996; Chinese hamster ovary cells in Kull et al, 1999). Agonist occupancy of the A 2A receptor blunted high-affinity agonist binding to the D 2 receptor in the absence of GTP; hence, the effect was proposed to be accounted for by an interaction at the level of the receptors or of receptor-G protein complexes.…”
Section: Introductionmentioning
confidence: 72%
See 1 more Smart Citation
“…This effect was originally observed in rat striatal membranes (Ferré et al, 1991b), and subsequently also documented upon heterologous expression of the receptors in fibroblast cell lines (Ltk-murine fibroblasts in Dasgupta et al, 1996; Chinese hamster ovary cells in Kull et al, 1999). Agonist occupancy of the A 2A receptor blunted high-affinity agonist binding to the D 2 receptor in the absence of GTP; hence, the effect was proposed to be accounted for by an interaction at the level of the receptors or of receptor-G protein complexes.…”
Section: Introductionmentioning
confidence: 72%
“…Upon NGF-induced differentiation of PC12 cells, mGluR7A was indeed delivered to the tips of the extending neurites (data not shown). (Ferré et al, 1991b), Ltk-murine fibroblasts (Dasgupta et al, 1996), and Chinese hamster ovary (CHO) cells . We therefore tested the effects of the A 2A agonist CGS21680 on the binding of the D 2 agonist [ 125 I]OH-PIPAT bound with high affinity to about 40% of the D 2 dopamine receptors (B max ¼ 26 7 5 ffmol/mg) that were labeled by the antagonist (cf Figure 1a).…”
Section: Heterologous Expression Of G Protein-coupled Receptors In Pcmentioning
confidence: 99%
“…Although a primary effect of low doses of caffeine is antagonism of adenosine receptors (Daly 1993), a secondary effect of adenosine A2 antagonism is a disinhibition of dopamine D2 receptors (Dasgupta et al 1996;Fuxe et al 1998). Cocaine seeking has been attributed to activation of dopamine D2-like receptors (Self et al 1996) which raises the possibility that caffeine-produced cocaine seeking might similarly be due to adenosine A2/dopamine D2 interactions.…”
Section: Discussionmentioning
confidence: 99%
“…The primary effect of low doses of caffeine is blockade of adenosine receptors with secondary effects on a number of neurochemical systems (see Daly 1993 for review), and many of the behavioral effects of caffeine and other methylxanthines are correlated with their potency as adenosine antagonists (Snyder et al 1981;Katims et al 1983;Mumford and Holtzman 1991b). Secondary to this effect at adenosine receptors, caffeine also has effects on dopaminergic substrates (Fuxe et al 1998) via interactions between adenosine A2 and dopamine D2 receptors (Ferre et al 1991(Ferre et al , 1993Dasgupta et al 1996;Fuxe et al 1998). The ability of caffeine to reinstate extinguished cocaine-taking behavior might be related to these effects, particularly in light of the hypothesized role of activation of dopamine D2 receptors in cocaine seeking.…”
mentioning
confidence: 99%
“…It is now recognized that intramembrane receptor interactions constitute a common biochemical characteristic of receptor heteromers [14,[23][24][25]. The antagonistic A 2A -D 2 intramembrane receptor interaction has been repeatedly reported by different research groups in membrane preparations from different transfected cell lines and from human and rat striatum [28][29][30][31][32][33][34]. In these membrane preparations, the addition of a selective A 2A receptor agonist decreases the ability of dopamine (or a D 2 receptor agonist) to displace the binding of a selective D 2 receptor radioligand [28][29][30][31][32][33][34] (Fig.…”
Section: The Antagonistic a 2a -D 2 Intramembrane Recep-tor Interactionmentioning
confidence: 95%