Adenosine as substrate and receptor agonist in the ovary

Billig, Håkan; Rosberg, Sten; Johanson, C.; Ahrén, Kurt

doi:10.1016/0039-128x(89)90045-7

Cited by 8 publications

(3 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar findings were observed in membranes from luteinized ovaries from superovulated rats induced by injection with pregnant mare serum gonadotropin (PMSG) and in homogenates of isolated cells from luteal bodies; moreover, it was shown that ADO analogues incremented progesterone synthesis. In these preparations, pharmacological evidence also indicated the participation of A2A receptor in the adenosinergic induction of cAMP accumulation, suggesting that ADO is a paracrine regulator of the luteal body's endocrine activity [25].…”

Section: Purinergic Signaling In the Ovary 31 Granulosa And Luteal Cmentioning

confidence: 92%

Purinergic Signaling: A New Regulator of Ovarian Function

Dı́az-Muñoz¹,

Campos-Contreras²,

Juárez-Mercado³

et al. 2019

Adenosine Triphosphate in Health and Disease

View full text Add to dashboard Cite

Purinergic signaling is a sophisticated system of elements in which ATP and related molecules function as intercellular messengers. When ATP is released into the extracellular space, it activates specific receptors that belong to the P2 family. In parallel, ectonucleotidases transform ATP in its dephosphorylated metabolites including adenosine, which stimulates P1 receptors. The activity of both receptors influences various cellular processes. Moreover, metabolic conditions are concatenated with purine signaling to conform a dynamic and continuous informational network. The role of purinergic signaling in ovarian cells has been investigated, for instance, it is known that cells conforming the follicle express functional receptors that modulate basic cellular process such as proliferation, induction of apoptotic cell death, and steroidogenesis. In this chapter, we review contemporary information on purinergic action in ovarian cell physiology and state its relevance in this field.

show abstract

Section: Purinergic Signaling In the Ovary 31 Granulosa And Luteal Cmentioning

confidence: 92%

Purinergic Signaling: A New Regulator of Ovarian Function

Dı́az-Muñoz¹,

Campos-Contreras²,

Juárez-Mercado³

et al. 2019

Adenosine Triphosphate in Health and Disease

View full text Add to dashboard Cite

show abstract

“…Early studies on rat and human granulosa and luteal cells showed that adenosine, via a specific receptor, potentiates the accumulation of cyclic adenosine monophosphate (cAMP) and the steroidogenic response induced by LH and FSH (Behrman et al, ; Polan et al, ). In granulosa cells obtained from mouse preovulatory follicles, this potentiating effect on cAMP production in the presence of gonadotropins is mediated by ADORA2, suggesting that signaling through adenosine and gonaotropins are coupled in order to accelerate cAMP production in these cells (Billig and Rosberg, ; Billig et al, ). Furthermore, adenosine was reported to abolish the anti‐gonadotropic effect of prostaglandin F 2 α (Behrman et al, ), which corroborates its positive effect on steroidogenesis.…”

Section: Purinergic Signaling In the Ovarymentioning

confidence: 99%

Purinergic signaling in the ovary

Martinez-Ramirez

Vázquez‐Cuevas

2015

Molecular Reproduction Devel

View full text Add to dashboard Cite

SUMMARYAdenosine triphosphate (ATP) is released from the cell by multiple mechanisms. The extracellular form of this purine is processed by ectonucleotidases, resulting in a variety of dephosphorylated metabolites that can bind to specific receptors found in the membrane of target cells; such purinergic signaling is important as an autocrineparacrine intercellular communication system that influences tissue physiology. In this review, we summarize the studies analyzing purinergic activity in the ovary, which can modulate cellular physiologyÀ Àincluding sensitivity to gonadotropinsÀ Àin several ovarian cell types, including the cumulus-cell complex, granulosa cells, theca cells, and the ovarian surface epithelium. These functions, thus, support a role for ATP as an important intra-ovarian messenger, and open new lines of research that can improve our understanding of mechanisms regulating ovarian function and the finetuning of folliculogenesis.Mol. Reprod. Dev. 82: 839À848, 2015. ß

show abstract

“…In the female there is little published information on the effect of adenosine in female reproduction. Adenosine appears to modulate gonadotrophin‐stimulated cAMP production in luteal (Baum & Ahern, 1986) and granulosa cells (Billig et al. , 1989) and it also modifies the action of oestradiol and progesterone on the myometrium (Thomas et al.…”

Section: Reproductive Systemmentioning

confidence: 99%

Possible therapeutic benefits of adenosine‐potentiating drugs in reducing age‐related degenerative disease in dogs and cats

Scaramuzzi

Baker²

2003

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

Adenosine is a ubiquitous, biologically important molecule that is a precursor of other biologically active molecules. It also is a component of some co-factors and has distinct physiological actions in its own right. Levels are maintained by synthesis from dietary precursors and re-cycling. The daily turnover of adenosine is very high. Adenosine can act either as a hormone by binding to adenosine receptors, four adenosine receptor subtypes have been identified, and as an intracellular modulator, after transport into the cell by membrane transporter proteins. One of the principal intracellular actions of adenosine is inhibition of the enzyme phosphodiesterase. Extracellular adenosine also has specific neuromodulatory actions on dopamine and glutamate. Selective and nonselective agonists and antagonists of adenosine are available. The tasks of developing, evaluating and exploiting the therapeutic potential of these compounds is still in its infancy. Adenosine has actions in the central nervous system (CNS), heart and vascular system, skeletal muscle and the immune system and the presence of receptors suggests potential actions in the gonads and other organs. Adenosine agonists improve tissue perfusion through actions on vascular smooth muscle and erythrocyte fluidity and they can be used to improve the quality of life in aged dogs. This article reviews the therapeutic potential of adenosine-potentiating drugs in the treatment of age-related conditions in companion animals, some of which may be exacerbated by castration or spaying at an early age.

show abstract

Adenosine as substrate and receptor agonist in the ovary

Cited by 8 publications

References 65 publications

Purinergic Signaling: A New Regulator of Ovarian Function

Purinergic Signaling: A New Regulator of Ovarian Function

Purinergic signaling in the ovary

Possible therapeutic benefits of adenosine‐potentiating drugs in reducing age‐related degenerative disease in dogs and cats

Contact Info

Product

Resources

About