Adenosine deaminase polymorphism in sardinia

Lucarelli, P.; Agostino, R.; Palmarino, R.; Bottini, E.

doi:10.1007/bf00273025

Cited by 12 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They pointed out that like the Acid phosphatase isozymes, those for Adenosine deaminase also possessed SH groups, and that the products of the ADA alleles might also differ in their response to oxidation. The Gd5 allele frequency at Plati is low, and for ADA2 it is high; this would be in accordance with the predictions of Lucarelli et al (1971). However, if this argument is taken further, problems arise.…”

Section: Malariasupporting

confidence: 72%

“…The low level of the P allele in Plati, therefore, could be due to past exposure to malaria. Lucarelli et al (1971) put forward a similar hypothesis to explain the variability ofthe ADA2 gene frequency in Mediterranean populations. Lucarelli et al (1971) confirmed the negative correlation between the GdE gene, and also found a negative relationship between the GdE and ADA2 genes.…”

Section: Malariamentioning

confidence: 98%

“…Lucarelli et al (1971) put forward a similar hypothesis to explain the variability ofthe ADA2 gene frequency in Mediterranean populations. Lucarelli et al (1971) confirmed the negative correlation between the GdE gene, and also found a negative relationship between the GdE and ADA2 genes. They pointed out that like the Acid phosphatase isozymes, those for Adenosine deaminase also possessed SH groups, and that the products of the ADA alleles might also differ in their response to oxidation.…”

Section: Malariamentioning

confidence: 98%

See 2 more Smart Citations

Genetic factors in the population of Plati, Greece

Tills

Warlow

Lord

et al. 1983

American J Phys Anthropol

View full text Add to dashboard Cite

One-thousand, thirty-eight individuals from Plati, Greece were examined for the following red cell antigens, serum proteins, and red cell enzymes A A1 Ai B H; MNSs Mg Henshaw Nya Mur Vw; CCwcDEeCe; K k Kpa Kpb Jsa Jsb; P1; Lua; Fy1 Fy2; Jka Jkb; Wra; Zt; Vel; Swa; Jensen, Radin, Gerbich, Diego, Gregory, Haptoglobin, Transferrin, Acid phosphatase, Adenylate kinase, Adenosine deaminase, Esterase-D, Glucose-6-phosphate dehydrogenase, Phosphoglucomutase, 6-Phosphogluconate dehydrogenase, Phosphohexose isomerase, Lactate dehydrogenase, Malate dehydrogenase, and Superoxide dismutase. The results are discussed in detail and compared with other Greek and neighbouring populations. Because of the Plati population's long history of residence in the Cappadocian area of Turkey the data have been compared, whenever possible, with results for that region.

show abstract

Section: Malariasupporting

confidence: 72%

Section: Malariamentioning

confidence: 98%

Section: Malariamentioning

confidence: 98%

See 1 more Smart Citation

Genetic factors in the population of Plati, Greece

Tills

Warlow

Lord

et al. 1983

American J Phys Anthropol

View full text Add to dashboard Cite

show abstract

“…An association between the adenosine deaminase (ADA) genetic polymorphism and past malarial morbidity was described by our group in a study on adaptation to malaria in the Sardinian population (Lucarelli et al, 1971). More recently, it was demonstrated that glycophorin A, a glycoprotein controlled by the MN system, is the main ligand for plasmodium falciparum (Cartron, 1996).…”

mentioning

confidence: 92%

Adaptation to past malarial endemia and susceptibility to common diseases in modern populations: A study of adenosine deaminase and MN blood group genetic polymorphisms

Bottini¹,

Stefanini²,

Lucarelli³

et al. 2005

American J Phys Anthropol

Self Cite

View full text Add to dashboard Cite

We carried out a study of adenosine deaminase (ADA) and MN blood group genetic polymorphisms in relation to past malarial morbidity in Sardinia and in relation to susceptibility to allergic asthma (a Th2 disorder) and Crohn's disease (a Th1 disorder) in the population of Rome. Eight hundred and eight schoolchildren, aged 7--14 years from 14 Sardinian villages located in the central area of the island, were considered. One hundred and twenty-two children with allergic asthma and 39 adult patients with Crohn's disease from the population of Rome were also studied. The data suggest an interaction between the two systems concerning resistance/susceptibility, both to malaria and to the diseases considered. In Sardinia, the frequency of the *L(M)/ADA*2 gametic type is negatively correlated with past malarial endemia, suggesting an increased susceptibility to malaria leading to its decrease in areas with high malarial endemia. In Rome, this gametic type is correlated negatively to allergic asthma and positively to Crohn's disease, suggesting a protective effect against allergic asthma and increased susceptibility to Crohn's disease.

show abstract

“…Adenosine deaminase is present on the surface of lymphocytes, where it acts as ectoenzyme and also has a role in the maturation of the immune system during ontogenesis. 8 Previous studies 9 have shown that, in Sardinia, allele *2 of ADA locus 1 (ADA1) has a lower frequency in areas of heavy past malarial morbidity. More recently, it has been shown that the ADA locus is composed of 12 exons.…”

mentioning

confidence: 99%