Adenosquamous Carcinoma Affecting the Maxilla: A Case Report and Review

Abstract

Adenosquamous carcinoma of the head and neck (ASC) is a rare and aggressive variant of squamous cell carcinoma, a locally aggressive malignancy characterized by the presence of two distinct components: a squamous cell carcinoma and an adenocarcinoma. The purpose of this study was to report an additional rare case of adenosquamous carcinoma affecting the maxilla, with clinical microscopic features and a complex mid-facial rehabilitation.

Adenosquamous Carcinoma with the Acantholytic Feature in the Oral Cavity: A Case Report and Comprehensive Literature Review

“…However, CK7 was negative, and CAM5.2 was positive only in a small number of cancer cells in the present case. The glandular components of reported cases of oral ASC were typically positive for CK7 [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. The mucin-containing cells were CEA-positive and p40-negative, similar to the immunohistochemical results for ASC reported by Satomi et al [ 15 ].…”

“…From our comprehensive literature review of ASC arising in the oral cavity ( Table 1 ), 50 cases, including the present case, have been reported [ 2 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 23 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ], and the clinical information of the review is summarized in Table 2 . The median age of the patients was 60 (range 22–97).…”