Adenoviruses

Benfield, David A.; Hesse, Richard

doi:10.1002/9781119350927.ch24

Cited by 4 publications

(18 citation statements)

References 32 publications

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“…Porcine adenoviruses (PAdV) are double-stranded DNA viruses that belong to the genus Mastadenovirus within the family Adenoviridae [ 1 ]. To date, at least three species ( Porcine mastadenovirus A ( PAdV-A ), B ( PAdV-B ) and C ( PAdV-C )) and five serotypes (PAdV-1 to -5) have been recognized among PAdVs, with PAdV serotype 1-3, PAdV-4, and PAdV-5 belonging to species PAdV-A , PAdV-B , and PAdV-C , respectively [ 1 , 2 ]. Two additional PAdV serotypes (isolates GK/K92 and TG/K79) have also been proposed [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…PAdV is considered as a low-grade porcine pathogen that rarely causes diseases of economic concern in domestic swine populations [ 2 , 7 ]. Since PAdVs are mostly associated with subclinical/asymptomatic infections, they (PAdV-3 and -5) have been used to develop viral vector vaccines against important porcine diseases and in gene transfer research [ 3 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Since PAdVs are mostly associated with subclinical/asymptomatic infections, they (PAdV-3 and -5) have been used to develop viral vector vaccines against important porcine diseases and in gene transfer research [ 3 , 8 ]. PAdVs have been reported in healthy and clinically ill pigs [ 2 , 7 ]. In diseased pigs, PAdVs have been most commonly associated with diarrhea, although they have also been detected in animals with other clinical conditions (encephalitis, nephritis, respiratory disease, and reproductive disorders) [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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High Rates of Detection and Molecular Characterization of Porcine Adenovirus Serotype 5 (Porcine mastadenovirus C) from Diarrheic Pigs

et al. 2022

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Since the first report on isolation of porcine adenovirus serotype 5 (PAdV-5, species Porcine mastadenovirus C (PAdV-C)) from pigs with respiratory illness in Japan in 1987, PAdV-5 have been detected in a few fecal samples from healthy pigs and in some environmental samples. To date, only a single PAdV-5 strain (isolate HNF-70 from 1987) has been analyzed for the complete genome. We report here high detection rates of PAdV-5 (25.74%, 26/101 fecal samples) in diarrheic pigs at 3 different farms in the Caribbean country of Dominican Republic. After a long gap, the complete deduced amino acid sequences of the DNA-dependent DNA polymerase (pol) and hexon of two PAdV-5 strains (GES7 and Z11) were determined, revealing >99% sequence identities between PAdV-5 strains (HNF-70, GES7 and Z11) detected in different parts of the world and during different time periods (1987, and 2020–2021). By phylogenetic analysis, the putative hexon and pol of HNF-70, GES7 and Z11 exhibited similar clustering patterns, with the PAdV-5 strains forming a tight cluster near ruminant AdVs, distinct from the species PAdV-A and -B. GES7 and Z11 retained the various conserved features present in the putative pol and major late promoter region of HNF-70. Considering the paucity of data on current epidemiological status and genetic diversity of PAdV in porcine populations, our findings warrant similar studies on PAdV-5 and other PAdVs in clinically ill and healthy pigs. To our knowledge, this is the first report on detection and molecular characterization of PAdV-5 (PAdV-C) from diarrheic pigs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High Rates of Detection and Molecular Characterization of Porcine Adenovirus Serotype 5 (Porcine mastadenovirus C) from Diarrheic Pigs

et al. 2022

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“…For example, adenoviruses were present in all pigs, and 16 out of 18 pigs were positive for picornaviruses. Porcine adenovirus is ubiquitous throughout the world; although the virus has been isolated in connection to disease investigations, it is not considered a major pathogen but rather is believed to often result in subclinical infection [ 27 ]. There are three species of porcine adenovirus recognised: porcine mastadenovirus A (porcine adenovirus 1–3), porcine mastadenovirus B (porcine adenovirus 4), and porcine mastadenovirus C (porcine adenovirus 5) [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Characterisation of the Virome of Tonsils from Conventional Pigs and from Specific Pathogen-Free Pigs

Blomström

Fossum

et al. 2018

Viruses

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Porcine respiratory disease is a multifactorial disease that can be influenced by a number of different microorganisms, as well as by non-infectious factors such as the management and environment of the animals. It is generally believed that the interaction between different infectious agents plays an important role in regard to respiratory diseases. Therefore, we used high-throughput sequencing combined with viral metagenomics to characterise the viral community of tonsil samples from pigs coming from a conventional herd with lesions in the respiratory tract at slaughter. In parallel, samples from specific pathogen-free pigs were also analysed. This study showed a variable co-infection rate in the different pigs. The differences were not seen at the group level but in individual pigs. Some viruses such as adenoviruses and certain picornaviruses could be found in most pigs, while others such as different parvoviruses and anelloviruses were only identified in a few pigs. In addition, the complete coding region of porcine parvovirus 7 was obtained, as were the complete genomes of two teschoviruses. The results from this study will aid in elucidating which viruses are circulating in both healthy pigs and in pigs associated with respiratory illness. This knowledge is needed for future investigations into the role of viral-viral interactions in relation to disease development.

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“…Human adenovirus is a double-stranded DNA virus with over 60 serotypes divided into seven subgroups, or species [1]. The virus triggers both the innate and adaptive immune response in humans, and its various clinical presentations depend on age group, immune status, and adenovirus species [2].…”

Section: Introductionmentioning

confidence: 99%

17-Month-Old Girl With Severe, Prolonged Lethargy and Somnolence

Lure¹,

Coppola²,

Guyer³

et al. 2021

Cureus

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A 17-month-old girl arrived at the pediatric ED with decreased responsiveness. She was lethargic, localizing only to noxious stimuli with vital signs significant for fever of 103.8 °F, heart rate of 185 beats/min, respiratory rate of 12 breaths/min, blood pressure of 100/59 mmHg, and oxygen saturation level of 88% on room air. She was admitted to the pediatric intensive care unit (PICU) due to concerns of septic meningitis with altered mental status and respiratory distress, and was treated with antibiotics. A respiratory viral panel (RVP) was positive for adenovirus, resulting in all antibiotics being discontinued. She remained lethargic until day nine of illness, when she had improved almost completely to her baseline. Polymerase chain reaction (PCR) of her cerebral spinal fluid returned positive for adenovirus serotype A, thus confirming our case of transient adenovirus encephalopathy. This case illustrates the importance of keeping adenovirus in the differential for encephalopathy versus a neurologic abnormality or other malignant or infectious etiology.

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Adenoviruses

Cited by 4 publications

References 32 publications

High Rates of Detection and Molecular Characterization of Porcine Adenovirus Serotype 5 (Porcine mastadenovirus C) from Diarrheic Pigs

High Rates of Detection and Molecular Characterization of Porcine Adenovirus Serotype 5 (Porcine mastadenovirus C) from Diarrheic Pigs

Characterisation of the Virome of Tonsils from Conventional Pigs and from Specific Pathogen-Free Pigs

17-Month-Old Girl With Severe, Prolonged Lethargy and Somnolence

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