Adenoviruses - from pathogens to therapeutics: a report on the 10th International Adenovirus Meeting

Greber, Urs F.; Arnberg, Niklas; Wadell, Göran; Benkő, Mária; Kremer, Eric J.

doi:10.1111/cmi.12031

Cited by 25 publications

(21 citation statements)

References 39 publications

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“…Nevertheless, SN and HI testing should continue to be used as an additional criterion in order to comply with the current definitions of the International Committee on Taxonomy of Viruses (ICTV) (41). Recently, the full-genome sequencing of every prototype HAdV strain was completed, including a typing algorithm that includes the sequences supporting serological features (8). It is therefore conceivable that it will be possible to impute serologic test results by computing genomic sequence data, thus possibly obviating and replacing SN and HI assays.…”

Section: Present Controversies In Hadv Typingmentioning

confidence: 99%

“…Despite a number of studies addressing the possible role of HAdVs in human malignant disease, their putative oncogenicity in humans has remained enigmatic (5-7). Investigations of adenovirus biology have led to Nobel Prize-winning discoveries in mRNA splicing and to important progress in the understanding of antigen presentation to T cells (8). Moreover, the ability of adenoviruses to infect many cell types facilitated their exploitation as vectors for gene delivery to generate new tools for innovative treatments of important diseases, such as cancer and cardiovascu-lar disorders (9)(10)(11)(12)(13).…”

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confidence: 99%

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Adenovirus Infections in Immunocompetent and Immunocompromised Patients

2014

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SUMMARY Human adenoviruses (HAdVs) are an important cause of infections in both immunocompetent and immunocompromised individuals, and they continue to provide clinical challenges pertaining to diagnostics and treatment. The growing number of HAdV types identified by genomic analysis, as well as the improved understanding of the sites of viral persistence and reactivation, requires continuous adaptions of diagnostic approaches to facilitate timely detection and monitoring of HAdV infections. In view of the clinical relevance of life-threatening HAdV diseases in the immunocompromised setting, there is an urgent need for highly effective treatment modalities lacking major side effects. The present review summarizes the recent progress in the understanding and management of HAdV infections.

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Section: Present Controversies In Hadv Typingmentioning

confidence: 99%

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confidence: 99%

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

2014

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“…Yet, to date there are no effective drugs for the treatment of HAdV infections. Even the well-established nucleoside inhibitor cidofovir has low clinical efficacy (Lenaerts and Naesens, 2006;Skevaki et al, 2011;Greber et al, 2013).…”

Section: Adenovirusmentioning

confidence: 99%

Innate Immunity to Adenovirus

et al. 2014

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Human adenoviruses are the most widely used vectors in gene medicine, with applications ranging from oncolytic therapies to vaccinations, but adenovirus vectors are not without side effects. In addition, natural adenoviruses pose severe risks for immunocompromised people, yet infections are usually mild and selflimiting in immunocompetent individuals. Here we describe how adenoviruses are recognized by the host innate defense system during entry and replication in immune and nonimmune cells. Innate defense protects the host and represents a major barrier to using adenoviruses as therapeutic interventions in humans. Innate response against adenoviruses involves intrinsic factors present at constant levels, and innate factors mounted by the host cell upon viral challenge. These factors exert antiviral effects by directly binding to viruses or viral components, or shield the virus, for example, soluble factors, such as blood clotting components, the complement system, preexisting immunoglobulins, or defensins. In addition, Toll-like receptors and lectins in the plasma membrane and endosomes are intrinsic factors against adenoviruses. Important innate factors restricting adenovirus in the cytosol are tripartite motif-containing proteins, nucleotide-binding oligomerization domain-like inflammatory receptors, and DNA sensors triggering interferon, such as DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 and cyclic guanosine monophosphate-adenosine monophosphate synthase. Adenovirus tunes the function of antiviral autophagy, and counters innate defense by virtue of its early proteins E1A, E1B, E3, and E4 and two virusassociated noncoding RNAs VA-I and VA-II. We conclude by discussing strategies to engineer adenovirus vectors with attenuated innate responses and enhanced delivery features.

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“…Adenoviruses are widespread pathogens employing a stepwise uncoating programme during entry [49,50]. Their structure closely relates to bacteriophage PRD1 from the family of tectiviridae with a unique T=25 geometry secured by cementing proteins [51-8 53].…”

Section: Mechanical Cuesmentioning

confidence: 99%

Uncoating of non-enveloped viruses

Suomalainen¹,

Greber²

2013

Current Opinion in Virology

106

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Non-enveloped viruses enclose their genome in capsids built of repetitive polypeptides interlinked with cementing proteins, divalent cations or disulphides. Interactions are broken in a stepwise manner during entry into cells leading to genome uncoating. Receptor or proteases induce conformational changes in case of rhinovirus, poliovirus or adenovirus, and thereby provide direct uncoating cues. Chemical cues from low endosomal pH activate rhinovirus or aphtovirus, and oxido-reductases mediate disulphide reshuffling of polyomavirus. Cellular motors provide a third class of cues as shown by adenoviruses. These examples highlight the diversity of cellular factors triggering virus uncoating, and offer new perspectives for the development of antivirals.

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Adenoviruses - from pathogens to therapeutics: a report on the 10th International Adenovirus Meeting

Cited by 25 publications

References 39 publications

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

Innate Immunity to Adenovirus

Uncoating of non-enveloped viruses

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