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“…It has been hypothesized that drug holidays from medication could partially reverse the adaptive effects of chronic pharmacological stimulation and re-sensitize neurons when medication is restarted (Howland, 2009). One study suggests that children with ADHD may initially manage with a smaller dose when methylphenidate treatment is restarted after a drug holiday (Davis & Sabir, 2009). …”
Section: Discussionmentioning
confidence: 99%
“…It has been hypothesized that drug holidays from medication could partially reverse the adaptive effects of chronic pharmacological stimulation and re-sensitize neurons when medication is restarted (Howland, 2009). One study suggests that children with ADHD may initially manage with a smaller dose when methylphenidate treatment is restarted after a drug holiday (Davis & Sabir, 2009). …”
Section: Discussionmentioning
confidence: 99%
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