Adhérence des prestataires du secteur privé à la politique de prise en charge des cas de paludisme simple à Madagascar

Randriatsarafara, Fidiniaina Mamy; Mandrosovololona, Vatsiharizandry; Andrianirinarison, Jean Claude; Rakotondrandriana, Antsa Nomenjanahary; Randrianarivo-Solofoniaina, Armand Eugène; Ratsimbasoa, Arsène; Rakotomanga, Jean de Dieu Marie

doi:10.11604/pamj.2019.32.79.14721

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…Therefore adapting the diagnostic tools to the regional epidemiology is likely to strengthen malaria control in Mali [48,49] . The use of RDTs that are capable to detect pan-Plasmodium antigens, such as lactate dehydrogenase (pLDH) or aldolase, may improve malaria diagnosis in region where non-P. falciparum Plasmodium species are endemic [13,50].…”

Section: Discussionmentioning

confidence: 99%

“…The RDT is based on the detection in the blood of the antigen Histidin Rich Protein 2 (HRP2) specific to Plasmodium falciparum, which is the most prevalent species in Mali [11]. It is most frequently used in primary health care facilities and at the community level by community health workers (CHWs) because of its easy handling [12,13]. It is advantageous in providing results within 15 minutes and discriminating malaria from non-malaria fevers through the detection of at least one specific antigen.…”

Section: Introductionmentioning

confidence: 99%

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Performance of Rapid Diagnostic Tests for Malaria Diagnosis in Mali

Dembélé,

Cissoko,

Diarra

et al. 2023

Preprint

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Background: First-line biological diagnosis of malaria in Mali is based on the use of rapid diagnostic tests (RDT), which detect in the blood the Histidin Rich Protein 2 antigen, specific to Plasmodium falciparum. Our study, based on a real-time polymerase chain reaction (qPCR) gold-standard diagnosis, aims to evaluate the performance of RDTs used in Mali and to describe the distribution of Plasmodium species in each administrative regions of Mali; Methods: We collected RDT cassettes in 47 sites of the nine regions of Mali. We randomly selected 150 malaria-negative and up to 30 malaria-positive RDTs from each regions. DNA was extracted from the RDTs’ nitrocellulose strip and then assayed with a pan-Plasmodium qPCR. Positive samples were then analyzed with qPCRs specific for P. falciparum, P. malariae, P. vivax, and P. ovale; Results: Of the 1,389 tested by qPCR RDTs, 258 (18.6%) were positive for Plasmodium spp. P.falciparum was the most predominant (97.3%). However, the prevalence of P.vivax reach 21.1% in the Ménaka region in the north; Conclusion: Overall, RDT diagnostic indices are adequate for the biological diagnosis of malaria in Mali. Our finding support the adjustment of RDTs to the local epidemiology.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Performance of Rapid Diagnostic Tests for Malaria Diagnosis in Mali

Dembélé,

Cissoko,

Diarra

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The RDT is based on the detection of the antigen Histidin Rich Protein 2 (HRP2) antigen in the blood, specific to Plasmodium falciparum, which is the most prevalent species in Mali [11]. It is most frequently used in primary healthcare facilities and at the community level by community health workers (CHWs) because of its easy handling [13,14]. It is advantageous in providing results within 15 min and discriminating malaria from non-malaria fevers through the detection of at least one specific antigen.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Performance of Rapid Diagnostic Tests for Malaria Diagnosis and Mapping of Different Plasmodium Species in Mali

Dembélé,

Cissoko,

Diarra

et al. 2024

IJERPH

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Background: The first-line diagnosis of malaria in Mali is based on the use of rapid diagnostic tests (RDT) that detect the Histidin Rich Protein 2 (HRP2) antigen specific to Plasmodium falciparum. Our study, based on a real-time polymerase chain reaction (qPCR) gold standard, aimed to describe the distribution of the Plasmodium species in each administrative region of Mali and to assess the performance of RDTs. Methods: We randomly selected 150 malaria-negative and up to 30 malaria-positive RDTs in 41 sites distributed in 9 regions of Mali. DNA extracted from the RDT nitrocellulose strip was assayed with a pan-Plasmodium qPCR. Positive samples were then analyzed with P. falciparum-, P. malariae-, P. vivax-, or P. ovale-specific qPCRs. Results: Of the 1496 RDTs, 258 (18.6%) were positive for Plasmodium spp., of which 96.9% were P. falciparum. The P. vivax prevalence reached 21.1% in the north. RDT displayed acceptable diagnostic indices; the lower CI95% bounds of Youden indices were all ≥0.50, except in the north (Youden index 0.66 (95% CI [0.44–0.82]) and 0.63 (95% CI [0.33–0.83]. Conclusions: Overall, RDT diagnostic indices are adequate for the biological diagnosis of malaria in Mali. We recommend the use of RDTs detecting P. vivax-specific antigens in the north.

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Knowledge and practices regarding malaria and the National Treatment Guidelines among public health workers in Equatorial Guinea

Blanco

Suárez-Sánchez

García

et al. 2021

Malar J

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Background In 2018, an estimated 228 million cases of malaria occurred worldwide. Countries are far from having achieved reasonable levels of national protocol compliance among health workers. Lack of awareness of treatment protocols and treatment resistance by prescribers threatens to undermine progress when it comes to reducing the prevalence of this disease. This study sought to evaluate the degree of knowledge and practices regarding malaria diagnosis and treatment amongst prescribers working at the public health facilities of Bata, Equatorial Guinea. Methods A cross-sectional survey was conducted in October-December 2017 amongst all public health professionals who attended patients under the age of 15 years, with suspected malaria in the Bata District of Equatorial Guinea. Practitioners were asked about their practices and knowledge of malaria and the National Malaria Treatment Guidelines. A bivariate analysis and a logistic regression model were used to determine factors associated with their knowledge. Results Among the 44 practitioners interviewed, 59.1% worked at a Health Centre and 40.9% at the District Hospital of Bata. Important differences in knowledge and practices between hospital and health centre workers were found. Clinical diagnosis was more frequently by practitioners at the health centres (p = 0.059), while microscopy confirmation was more frequent at regional hospital (100%). Intramuscular artemether was the anti-malarial most administrated at the health centres (50.0%), while artemether-lumefantrine was the treatment most used at the regional hospital (66.7%). Most practitioners working at public health facilities (63.6%) have a low level of knowledge regarding the National Malaria Treatment Guidelines. While knowledge regarding malaria, the National Malaria Treatment Guidelines and treatment resistances is low, it was higher amongst hospital workers than amongst practitioners at health centres. Conclusions It is essential to reinforce practitioners’ knowledge, treatment and diagnosis practices and use of the National Malaria Treatment Guidelines in order to improve malaria case management and disease control in the region. A specific malaria training programme ensuring ongoing updates training is necessary in order to ensure that greater experience does not entail obsolete knowledge and, consequently, inadequate diagnosis and treatment practices.

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Adhérence des prestataires du secteur privé à la politique de prise en charge des cas de paludisme simple à Madagascar

Cited by 5 publications

References 11 publications

Performance of Rapid Diagnostic Tests for Malaria Diagnosis in Mali

Performance of Rapid Diagnostic Tests for Malaria Diagnosis in Mali

Evaluation of the Performance of Rapid Diagnostic Tests for Malaria Diagnosis and Mapping of Different Plasmodium Species in Mali

Knowledge and practices regarding malaria and the National Treatment Guidelines among public health workers in Equatorial Guinea

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