Adherence Patterns of Histoplasma capsulatum Yeasts to Bat Tissue Sections

Suárez-Alvarez, Roberto; Pérez‐Torres, Armando; Taylor, Mária Lucía

doi:10.1007/s11046-010-9302-9

Cited by 12 publications

(11 citation statements)

References 13 publications

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“…The demonstration that H. capsulatum yeasts can adhere to different organ cryosections also provides evidence of an important mechanism for yeast colonization and dissemination that involves yeast cell adherence to host tissue architecture, probably including cellular surfaces and extracellular components (Sua´rez-Alvarez et al 2010). …”

Section: Discussionmentioning

confidence: 94%

“…So, the spectrophotometric method and the XTT reduction assay used in this study made it possible to evaluate fungal biofilm growth accurately. The characteristics of some surface molecules of a parasite could be important in parasite-adherence patterns and in the selection of the route of internalization into the host cells, as well as in extracellular dissemination (Sua´rez-Alvarez et al 2010). According to Long et al (2003) alveolar macrophages are able to recognize unopsonized H. capsulatum yeasts and microconidia during a infection via the b-chain (CD18) family of adhesion-promoting glycoproteins, LFA-1 (CD11a/CD18), CR3 (CD11b/CD18), and CR4 (CD11c/CD18).…”

Section: Discussionmentioning

confidence: 99%

“…capsulatum yeasts may adhere to lung, spleen, liver, gut, and have been seen in trachea cryosections of Artibeus hirsutus bats and BALB/c mice (Sua´rez-Alvarez et al 2010). A study performed by Sua´rez-Alvarez et al (2010) evaluated the adherence pattern of H. capsulatum yeasts with tissue sections from different organs of bats, in vitro. The results showed that lung tissue had the largest number of adhered yeasts and the trachea had the smallest number.…”

Section: Introductionmentioning

confidence: 99%

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Adhesion ofHistoplasma capsulatumto pneumocytes and biofilm formation on an abiotic surface

et al. 2012

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adhesion ofHistoplasma capsulatumto pneumocytes and biofilm formation on an abiotic surface

et al. 2012

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“…[204][205][206][207][208][209][210][211][212][213][214][215][216][217]. Important virulence factors for these fungi include thermal dimorphism which allows the pathogen to adapt/survive inside the host, and the capacity to produce biofilm in vitro, expression of phospholipase and melanin production [218][219][220][221][222][223].…”

Section: Paracoccidioidomycosismentioning

confidence: 99%

Update on Fungal Disease: From Establish Infection to Clinical Manifestation

Melo¹,

Scorzoni²,

Rossi³

et al. 2017

J Biotechnol Biomater

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Fungal diseases have emerged as an important cause of morbidity and mortality, especially among immunocompromised patients. Pathogenic fungi have evolved an array of virulence factors to survive within the host and to outwit immune defenses. Fungi may cause a wide range of diseases in humans that range in extent from superficial to disseminated infections. Generally, the site of infections classifies the type of fungal disease, which can be divided into superficial, cutaneous, subcutaneous and systemic. In addition, the fungal virulence factors determine whether the infection will become established in the host. A primary pathogen may infect an immunologically normal host, whereas, an opportunistic pathogen requires some compromise of the host immune defenses in order for the infection to become established. This article covers the main fungi that are responsible for the increase of the fungal infections.Keywords: Fungal infections; Virulence; Yeast; Opportunistic infections; Endemic mycosis Fungal InfectionsFungal diseases have changed constantly in the last years. The virulence of these microorganisms has been adapted according to the human host, promoting a range of clinical manifestation. Several are the ways by which fungi promote a disease depending on human body part involved by the microorganism and the immunologic system of the host [1].In this review, we discuss the main fungal pathogens responsible for causing several diseases, highlighting on their virulence associate to clinical manifestation and the difficulty to accomplish the treatment. Superficial and cutaneous fungal diseasesSuperficial and cutaneous fungal infections are very common and occur worldwide affecting millions of people, especially immunocompromised patients. The most common types of these infections are dermatophytosis (tinea or ringworm), pityriasis versicolor (formerly tinea versicolor) and candidiasis (moniliasis). These occur by fungal invasion into the skin, keratinized tissues and mucous membranes [2]. Trichosporon and Fusarium species also cause superficial fungal infection, but also may be considered an invasive pathogen that may cause a systemic infection [3,4].Dermatophytosis: Dermatophytes are fungi that invade keratinized structures of humans and animals producing a condition called dermatophytosis or, more commonly, tinea [5,6]. These fungi belong to three main genera Trichophyton, Microsporum and Epidermophyton, of these T. rubrum is the most prevalent species worldwide [7,8]. The mechanisms of pathogenicity of these fungi are not yet well understood. There are several studies focusing on keratinolytic proteases (keratinases) produced by dermatophytes, but it is not known how these fungi regulate the use of these proteases to obtain nutrients from the stratum corneum substrate they invade, and whether there are additional roles of these proteins in adhesion and immunomodulation [9].To establish the infection, the contact of arthroconidia or hyphal fragmens with the host skin is essential. The fungi express spe...

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“…It is one such respiratory fungal infection that accounts for about half a million cases per year only in the US. 108 The ability of H. capsulatum to form biofilms remained unknown for a long time until identified by Suárez-Alvarez et al 109 The researchers showed that H. capsulatum yeasts could adhere to the cryosections of different organs and further provided evidence for an important mechanism of colonization and spread of the yeasts, which involves adhesion of the microorganisms to the host tissues, including the cell surface and extracellular components. Two years later, Pitangui et al 110 demonstrated the in vitro ability of H. capsulatum to form biofilms and evaluated its invasion potential in cell lines.…”

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confidence: 99%

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Ramos¹,

Silva²,

Spósito³

et al. 2018

IJN

221

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Since the dawn of civilization, it has been understood that pathogenic microorganisms cause infectious conditions in humans, which at times, may prove fatal. Among the different virulent properties of microorganisms is their ability to form biofilms, which has been directly related to the development of chronic infections with increased disease severity. A problem in the elimination of such complex structures (biofilms) is resistance to the drugs that are currently used in clinical practice, and therefore, it becomes imperative to search for new compounds that have anti-biofilm activity. In this context, nanotechnology provides secure platforms for targeted delivery of drugs to treat numerous microbial infections that are caused by biofilms. Among the many applications of such nanotechnology-based drug delivery systems is their ability to enhance the bioactive potential of therapeutic agents. The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles, in controlling microbial biofilms by targeted drug delivery. Such utilization of these nanosystems has led to a better understanding of their applications and their role in combating biofilms.

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Adherence Patterns of Histoplasma capsulatum Yeasts to Bat Tissue Sections

Cited by 12 publications

References 13 publications

Adhesion ofHistoplasma capsulatumto pneumocytes and biofilm formation on an abiotic surface

Adhesion ofHistoplasma capsulatumto pneumocytes and biofilm formation on an abiotic surface

Update on Fungal Disease: From Establish Infection to Clinical Manifestation

Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

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