Adherence to Anticholinergic Therapy and Clean Intermittent Self-Catheterization in Patients With Multiple Sclerosis

Motavasseli, Damien; Chesnel, C.; Charlanes, A.; Menoux, Diane; Charoenwong, Francis; Breton, F. Le; Amarenco, G.

doi:10.5213/inj.1836054.027

Cited by 15 publications

(15 citation statements)

References 23 publications

(27 reference statements)

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“…Treatment of NDO are identical in HSP compared to SCI and MS, the first line being anticholinergics and if needed, intradetrusor injection of botulinum toxin A. Similar to what is observed in MS only 30% of patients performed CISC . We assume difficulties encountered in this population rely on the progressive evolution of the disease (and bladder symptoms) with a lack of adherence and acceptability to the technique …”

Section: Discussionmentioning

confidence: 74%

“…Similar to MS patients, an intensive education therapy program may be needed to allow them to understand the needs and benefits of CISC. Despite this, we often encounter difficulties to introduce CISC and obtain long‐term compliance to this therapeutic . This may explain why despite the importance of NDO‐DSD and chronic retention in our cohort, only 30% use CISC as micturition mode, often associated with spontaneous micturition.…”

Section: Discussionmentioning

confidence: 95%

“…Similar to what is observed in MS only 30% of patients performed CISC. 9 We assume difficulties encountered in this population rely on the progressive evolution of the disease (and bladder symptoms) with a lack of adherence and acceptability to the technique. 9 There is no recommendation regarding the time and modalities of initiation of CISC in this population.…”

Section: Clinical and Urodynamic Patterns Of Infra Pontine-supra Samentioning

confidence: 99%

“…9 We assume difficulties encountered in this population rely on the progressive evolution of the disease (and bladder symptoms) with a lack of adherence and acceptability to the technique. 9 There is no recommendation regarding the time and modalities of initiation of CISC in this population. Most patients experienced LUTS for a long time without entering a specialized neurourology follow-up and may have developed inappropriate coping strategies.…”

Section: Clinical and Urodynamic Patterns Of Infra Pontine-supra Samentioning

confidence: 99%

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Urological dysfunction in patients with hereditary spastic paraplegia

Joussain

Lévy

Charlanes

et al. 2019

Neurourology and Urodynamics

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Aims Purposes of this study were to describe lower urinary tract symptoms (LUTS) and related urodynamic patterns in patients with hereditary spastic paraplegia (HSP), and to characterize LUTS management and associated uronephrological complications. Methods We retrospectively reviewed medical files of HSP patients, consecutively followed in our Physical and Rehabilitation Medicine Department between 1999 and 2016. Clinical, urodynamic, and radiological data were collected and analyzed. Different treatments which have been prescribed and uronephrological complications were also recorded. Patients with other neurological or urological diseases were excluded. Results Thirty‐three patients with HSP were included. Mean duration of follow‐up was 8.1 ± 5 years, mean age 62 ± 14 years, and 70% were men. The most frequent LUTS was urgency and voiding dysfunction (both 69.7%). Incontinence and retention with a significant postvoid residue above 100 mL accounted for 66.7% and 57.6% of initial symptoms respectively. Neurogenic detrusor overactivity was diagnosed in 80.7% of patients. Two‐thirds of our cohort were treated with anticholinergics and 9.1% required intradetrusor botulinum‐toxin injections. Only 27.3% of patients performed clean intermittent self‐catheterization. Febrile urinary tract infections (21.2%), urolithiasis (15,1%), hydronephrosis (6%), and chronic renal failure (9.1%) were found. Conclusion Given their high prevalence and the risk of uronephrological complications, LUTS should be systematically assessed in HSP patients. The systematic screening of urological dysfunction in this population would improve its management, decrease the incidence of uronephrological complications, and increase the quality of life.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 95%

Section: Clinical and Urodynamic Patterns Of Infra Pontine-supra Samentioning

confidence: 99%

Section: Clinical and Urodynamic Patterns Of Infra Pontine-supra Samentioning

confidence: 99%

See 2 more Smart Citations

Urological dysfunction in patients with hereditary spastic paraplegia

Joussain

Lévy

Charlanes

et al. 2019

Neurourology and Urodynamics

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“…Whilst numerous questionnaires on bladder symptoms are available, the USP was chosen as it is a validated questionnaire that incorporates different domains of LUT symptoms and better describes the frequently mixed symptoms experienced by patients with MS. Although not specifically validated in neurological patients, it has been recommended as a screening tool for LUT symptoms in MS [13] and used as an outcome measure in previous studies of patients with MS [14][15][16] and other neurological conditions [17,18]. A ratio of the USP LS/total scores was calculated to account for the degree of voiding LUT symptoms compared to a patient's overall profile of LUT symptoms.…”

Section: Discussionmentioning

confidence: 99%

Use of a symptom-based questionnaire to screen for the presence of significant voiding dysfunction in patients with multiple sclerosis and lower urinary tract symptoms: a pilot study

Panicker

Haslam

et al. 2020

J Neurol

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Introduction Lower urinary tract dysfunction is common in people with multiple sclerosis, leading to overactive bladder symptoms, voiding difficulties or a combination. First-line medications for overactive bladder symptoms are effective. Current guidelines recommend measuring post-void residual volume (PVR) before commencing these treatments, as they can potentially exacerbate voiding difficulties in those with significant underlying voiding dysfunction (pre-treatment PVR > 100 ml). However, facilities to do so are not readily available to all clinicians, potentially delaying effective therapy. Aims To conduct a pilot study investigating the association between lower urinary tract symptoms and PVR volume in people with multiple sclerosis using a validated questionnaire and to determine if questionnaire scores can be used to exclude a significantly elevated (> 100 ml) PVR volume. Methods Patients with multiple sclerosis referred to a tertiary hospital uro-neurology service completed the Urinary Symptom Profile questionnaire and underwent PVR measurement by bladder ultrasound. A ratio of the questionnaire low stream score/total score was calculated to standardise the relative degree of voiding symptoms compared to overall lower urinary tract symptoms. Results Of 40 patients (29 females, mean age 50 years), 30% had an elevated PVR volume. PVR volume was correlated with low stream score and ratio of low stream/total score. A cutoff of > 0.15 for low stream/total score ratio had 92% sensitivity and 71% specificity in predicting an elevated PVR volume. Conclusion A symptom-based questionnaire maybe a useful screening tool to distinguish patients in whom PVR measurement is required from those who could safely start on treatment for overactive bladder symptoms.

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Tibial Nerve and Sacral Neuromodulation in the Multiple Sclerosis Patient with Voiding Dysfunction

Berg

Kim

2018

Curr Bladder Dysfunct Rep

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Adherence to Anticholinergic Therapy and Clean Intermittent Self-Catheterization in Patients With Multiple Sclerosis

Cited by 15 publications

References 23 publications

Urological dysfunction in patients with hereditary spastic paraplegia

Urological dysfunction in patients with hereditary spastic paraplegia

Use of a symptom-based questionnaire to screen for the presence of significant voiding dysfunction in patients with multiple sclerosis and lower urinary tract symptoms: a pilot study

Tibial Nerve and Sacral Neuromodulation in the Multiple Sclerosis Patient with Voiding Dysfunction

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