Adherence to inhaled corticosteroids prescribed once vs twice daily in children with asthma

Drouin, Olivier; Smyrnova, Anna; Betinjane, Natalie; Ducharme, Francine M

doi:10.1016/j.anai.2022.01.018

Cited by 8 publications

(3 citation statements)

References 38 publications

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“…Recruitment from a tertiary pediatric center clinic could, in theory, limit generalizability; however, the clinical population is quite diverse with regard to SES, race, and ethnicity [ 105 ]. Previous studies reported lower rates of controller medication prescription in patients with lower SES [ 106 ], leading to a potential selection bias.…”

Section: Discussionmentioning

confidence: 99%

“…Would that occur, it would likely be of similar magnitude for all participants in the study and not substantially influence the associations found. We will also be able to estimate the size of this effect by comparing adherence in this study with previously reported historical data on adherence from other children followed in the clinic [ 105 ].…”

Section: Discussionmentioning

confidence: 99%

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Impact of Unmet Social Needs, Scarcity, and Future Discounting on Adherence to Treatment in Children With Asthma: Protocol for a Prospective Cohort Study

Drouin¹,

Pérez²,

Barnett³

et al. 2023

JMIR Res Protoc

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Background Asthma is one of the most prevalent chronic diseases of childhood and disproportionately affects children with lower socioeconomic status. Controller medications such as inhaled corticosteroids significantly reduce asthma exacerbations and improve symptoms. However, a large proportion of children still have poor asthma control, in part owing to suboptimal adherence. Financial barriers contribute to hindering adherence, as do behavioral factors related to low income. For example, unmet social needs for food, lodging, and childcare may create stress and worry in parents, negatively influencing medication adherence. These needs are also cognitively taxing and force families to focus on immediate needs, leading to scarcity and heightening future discounting; thus, there is the tendency to attribute greater value to the present than to the future in making decisions. Objective In this project, we will investigate the relationship between unmet social needs, scarcity, and future discounting as well as their predictive power over time on medication adherence in children with asthma. Methods This 12-month prospective observational cohort study will recruit 200 families of children aged 2 to 17 years at the Asthma Clinic of the Centre Hospitalier Universitaire Sainte-Justine, a tertiary care pediatric hospital in Montreal, Canada. The primary outcome will be adherence to controller medication, measured using the proportion of prescribed days covered during follow-up. Exploratory outcomes will include health care use. The main independent variables will be unmet social needs, scarcity, and future discounting, measured using validated instruments. These variables will be measured at recruitment as well as at 6- and 12-month follow-ups. Covariates will include sociodemographics, disease and treatment characteristics, and parental stress. Primary analysis will compare adherence to controller medication, measured using the proportion of prescribed days covered, between families with versus those without unmet social needs during the study period using multivariate linear regression. Results The research activities of this study began in December 2021. Participant enrollment and data collection began in August 2022 and are expected to continue until September 2024. Conclusions This project will allow the documentation of the impact of unmet social needs, scarcity, and future discounting on adherence in children with asthma using robust metrics of adherence and validated measures of scarcity and future discounting. If the relationship between unmet social needs, behavioral factors, and adherence is supported by our findings, this will suggest the potential for novel targets for integrated social care interventions to improve adherence to controller medication and reduce risk across the life course for vulnerable children with asthma. Trial Registration ClinicalTrials.gov NCT05278000; https://clinicaltrials.gov/ct2/show/NCT05278000 International Registered Report Identifier (IRRID) PRR1-10.2196/37318

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of Unmet Social Needs, Scarcity, and Future Discounting on Adherence to Treatment in Children With Asthma: Protocol for a Prospective Cohort Study

Drouin¹,

Pérez²,

Barnett³

et al. 2023

JMIR Res Protoc

Self Cite

View full text Add to dashboard Cite

show abstract

“…Es importante además tratar de simplificar el esquema terapéutico de manera que se adapte mejor al paciente y sus necesidades. Al respecto se ha demostrado que el uso de la medicación 1 vez al día mejora la adherencia (10).…”

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Adherencia Al Tratamiento Del Asma en Niños

Herrera

2022

Neumol Pediatr

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Blood Eosinophils for Prediction of Exacerbation in Preschool Children With Recurrent Wheezing

Fitzpatrick

Grunwell

Cottrill

et al. 2023

The Journal of Allergy and Clinical Immunology: In Practice

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Adherence to inhaled corticosteroids prescribed once vs twice daily in children with asthma

Cited by 8 publications

References 38 publications

Impact of Unmet Social Needs, Scarcity, and Future Discounting on Adherence to Treatment in Children With Asthma: Protocol for a Prospective Cohort Study

Impact of Unmet Social Needs, Scarcity, and Future Discounting on Adherence to Treatment in Children With Asthma: Protocol for a Prospective Cohort Study

Adherencia Al Tratamiento Del Asma en Niños

Blood Eosinophils for Prediction of Exacerbation in Preschool Children With Recurrent Wheezing

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