Adherence to Medication Regimens is an Effective Indicator of Cognitive Dysfunction in Elderly Individuals

Mizokami, Fumihiro; Mase, Hiroki; Kinoshita, Tomoyasu; Kumagai, Takahiro; Furuta, K.; Ito, Kazuhiro

doi:10.1177/1533317515598859

Cited by 8 publications

(7 citation statements)

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“…Most studies that have examined the factors associated with sedentariness or inactivity have focused on psychosocial predictors. However, cognitive functions have recently been considered in adherence to treatment medication [ 12 , 13 ], but to our knowledge, no study has examined the predictive value of cognitive strategies in adherence to PA in healthy older adults. The aim of the present study was to identify cognitive and psychosocial determinants of the level of PA in independently living healthy older adults in France.…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between cognitive functioning and adherence has been studied either by examining populations with cognitive impairments [ 12 , 13 ] or by training populations in cognitive processes [ 14 – 18 ]. These studies have been principally carried out in the context of medication adherence.…”

Section: Introductionmentioning

confidence: 99%

“…These studies have been principally carried out in the context of medication adherence. For instance, studies have reported that older people with cognitive dysfunctions show poor medication adherence compared to healthy older people [ 12 ] and that working memory ability or habitual prospective memory facilitated recall of medication instructions [ 19 , 20 ]. In their systematic review on the efficacy of interventions to increase medication adherence among community-dwelling seniors with cognitive impairments, Kröger et al [ 13 ] have shown that reminder strategies are promising to improve adherence.…”

Section: Introductionmentioning

confidence: 99%

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Cognitive Strategies and Physical Activity in Older Adults: A Discriminant Analysis

André

Ferrand

Albinet

et al. 2018

Journal of Aging Research

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Background Although a number of studies have examined sociodemographic, psychosocial, and environmental determinants of the level of physical activity (PA) for older people, little attention has been paid to the predictive power of cognitive strategies for independently living older adults. However, cognitive strategies have recently been considered to be critical in the management of day-to-day living. Methods Data were collected from 243 men and women aged 55 years and older living in France using face-to-face interviews between 2011 and 2013. Results A stepwise discriminant analysis selected five predictor variables (age, perceived health status, barriers' self-efficacy, internal memory, and attentional control strategies) of the level of PA. The function showed that the rate of correct prediction was 73% for the level of PA. The calculated discriminant function based on the five predictor variables is useful for detecting individuals at high risk of lapses once engaged in regular PA. Conclusions This study highlighted the need to consider cognitive functions as a determinant of the level of PA and, more specifically, those cognitive functions related to executive functions (internal memory and attentional control), to facilitate the maintenance of regular PA. These results are discussed in relation to successful aging.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive Strategies and Physical Activity in Older Adults: A Discriminant Analysis

André

Ferrand

Albinet

et al. 2018

Journal of Aging Research

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“…with late-life depression and AD, or both, are known to have significantly lower treatment adherence rates possibly linked to reduced cognitive functioning and a greater number of comorbidities [92,93]. Although adherence to SSRI's in people with AD is greater than adherence to Tricyclic antidepressants, over 50% of people with AD discontinue all antidepressant medication within 6 months [94].…”

Section: The Efficacy Of Ssri's In the Treatment Of Depression In Admentioning

confidence: 99%

Depression in Alzheimer’s Disease: An Alternative Role for Selective Serotonin Reuptake Inhibitors?

Elsworthy

Aldred

2019

JAD

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Where a licence is displayed above, please note the terms and conditions of the licence govern your use of this document. When citing, please reference the published version. Take down policy While the University of Birmingham exercises care and attention in making items available there are rare occasions when an item has been uploaded in error or has been deemed to be commercially or otherwise sensitive.

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“…[2] Changes in medication adherence may be an additional early indicator of cognitive impairment. [3] Studies have shown that cognitive abilities are important for optimal medication adherence in older adults. [4–9]…”

Section: Introductionmentioning

confidence: 99%

Patterns of antihypertensive and statin adherence prior to dementia: findings from the adult changes in thought study

et al. 2019

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Background Detecting patients with undiagnosed dementia is an important clinical challenge. Changes in medication adherence might represent an early sign of cognitive impairment. We sought to examine antihypertensive and statin adherence trajectories in community-dwelling older adults, comparing people who went on to develop dementia to those who did not. Methods We analyzed data from Adult Changes in Thought (ACT), a population-based cohort study embedded within an integrated healthcare delivery system. Analyses included 4368 participants aged ≥65 years who had at least one follow-up visit. Research-quality dementia diagnoses were used to identify cases. We selected non-dementia control visits matched on age, sex, and study cohort that occurred at similar ACT follow-up time as the case’s dementia onset; we treated this as the index date. Participants were included if they were prevalent users of either a statin or antihypertensive medication on the first day of follow up – 3 years prior to the index date. Using prescription fill dates and days supply, we calculated daily binary medication availability measures for each participant (‘days covered’) over 3 years leading up to the index date. We used group-based trajectory models to identify patterns of antihypertensive and statin adherence, and used conditional logistic regression to examine associations between adherence trajectories and dementia. Results Four trajectories were identified for antihypertensive users (292 cases, 3890 control visits), including near perfect ( n = 1877, 36.6% cases, 45.5% controls), high ( n = 1840, 43.2% cases, 44.1% controls), moderate ( n = 365, 18.5% cases, 8.0% controls) and early poor adherence ( n = 100, 1.7% cases, 2.4% controls). Odds of dementia was 3 times greater for those with moderate antihypertensive adherence compared to those with near perfect adherence (adjusted OR 3.0, 95% CI 2.0, 4.3). Four trajectories were identified for statin users (148 cases, 1131 control visits), including high ( n = 1004, 75.0% cases, 79.0% controls), moderate ( n = 192, 19.6% cases, 14.4% controls), early poor ( n = 43, 2.0% cases, 3.5% controls), and delayed poor adherence ( n = 40, 3.4% cases, 3.1% controls). No association was detected between statin adherence trajectories and dementia. Conclusions Patterns of medication adherence may be useful to identify a subset of people at higher likelihood of developing dementia. Electronic supplementary material The online version of this article (10.1186/s12877-019-1058-6) contains supplementary material, which is available to authorized users.

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Adherence to Medication Regimens is an Effective Indicator of Cognitive Dysfunction in Elderly Individuals

Abstract: Declining IADL scores in the shopping and responsibility for own medications categories may be effective indices for predicting early-stage cognitive dysfunction in elderly individuals. Cognitive dysfunction screening at pharmacy counters may be useful.

Cited by 8 publications

References 30 publications

Cognitive Strategies and Physical Activity in Older Adults: A Discriminant Analysis

Cognitive Strategies and Physical Activity in Older Adults: A Discriminant Analysis

Depression in Alzheimer’s Disease: An Alternative Role for Selective Serotonin Reuptake Inhibitors?

Patterns of antihypertensive and statin adherence prior to dementia: findings from the adult changes in thought study

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