Adhesion molecules and atherosclerosis

Blankenberg, Stefan; Barbaux, Sandrine; Tiret, Laurence

doi:10.1016/s0021-9150(03)00097-2

Cited by 938 publications

(792 citation statements)

References 140 publications

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“…Non-invasive models include study of biomarkers that are present on the surface of endothelial cells or are expressed in response to several stimuli and have an important role in the process of leukocyte rolling, firm adhesion and transendothelial migration, biomarkers are either present on the surface of endothelial cells or are expressed in response to several stimuli and have an important role in the process of leukocyte rolling, firm adhesion and transendothelial migration [52,66,67]. Soluble CAMs are considered reliable biomarkers of atherosclerosis development and severity and to add to the predictive value of classic risk factors for coronary artery disease in healthy individuals and in patients [86].Another non-invasive technique is the use of ultrasonography to assess the degree of flow-mediated dilatation (FMD) of the brachial artery following an ischaemic stimulus [25,87].…”

Section: Available Methods For Assessment Of Endothelial Functionmentioning

confidence: 99%

“…Endothelium is involved in important homeostatic mechanisms of nonthrombotic vascular surfaces, vascular tone regulation and immunomodulation [39,51]. Several different clinical conditions, such as, hypertension ,dyslipidaemia diabetes mellitus , contribute to endothelial dysfunction thought to be a major link between infection, inflammation and atherosclerosis [39,[51][52][53][54][55].…”

Section: Endothelial Cell Function and Hivmentioning

confidence: 99%

“…Several observations in pathophysiologic studies in humans and animals led to the formulation of the response-to-injury hypothesis of atherosclerosis, which initially proposed that endothelial denudation was the first step in atherosclerosis [52].…”

Section: Endothelial Cell Function and Hivmentioning

confidence: 99%

“…Intercellular adhesion molecule (sICAM-1) and P-selectin are documented factors implicated in myocardial infarction and atherosclerosis [52]. High levels of this adhesion molecules represent early markers of the development of atherosclerosis [66,67].…”

Section: Endothelial Cell Function and Hivmentioning

confidence: 99%

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Endothelial function and cardiovascular diseases in HIV infected patient

Andrade¹,

Cotter²

2006

Braz J Infect Dis

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The HIV epidemic has dramatically changed the paradigm for the development of drug therapy in the last 15 years. The goal is now not only to provide an effective reduction of plasma viremia , but also to reconstitute the immune deficiency due to the progression of the disease. Significant problems with the metabolism of sugars and lipids lead to the appearance of well-documented disorders such as insulin resistance, abnormalities in lipid metabolism and lipodystrophy in those patients on prolonged therapy with antiretrovirals. The question of whether or not HAART-associated lipid disorders contribute to the premature development of coronary artery disease is of major importance for the HIV community. Endothelial injury is associated with disease-related biochemical abnormalities that are implicated in HIV pathogenesis. The exploration of endothelial function began in the early 1980s at the start of the epidemic. The study of endothelial function in HIV infection and its modifications by HAART is an exciting new field in clinical research; in this review the available information on cardiovascular diseases associated with HIV infection and its treatment are discussed.

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Section: Available Methods For Assessment Of Endothelial Functionmentioning

confidence: 99%

Section: Endothelial Cell Function and Hivmentioning

confidence: 99%

Section: Endothelial Cell Function and Hivmentioning

confidence: 99%

Section: Endothelial Cell Function and Hivmentioning

confidence: 99%

See 2 more Smart Citations

Endothelial function and cardiovascular diseases in HIV infected patient

Andrade¹,

Cotter²

2006

Braz J Infect Dis

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show abstract

“…40 Soluble CAMs (including ICAM-1, VCAM-1 and E-selectin) are increased in obese children. [41][42][43] While their pathophysiological role has not yet been fully elucidated, 44 soluble adhesion molecules are commonly used as a marker of endothelial cell activation. Furthermore, obese children have higher levels of markers of platelet activation (soluble Pselectin and CD40 ligand) than healthy weight children.…”

Section: Vascular Endothelial Functionmentioning

confidence: 99%