Adhesion of fibronectin, vitronectin, laminin, and collagen type IV to intraocular lens materials in pseudophakic human autopsy eyes

Linnola, Reijo J.; Werner, Liliana; Pandey, Suresh K; Escobar-Gómez, Marcela; Znoiko, Sergey L.; Apple, David J.

doi:10.1016/s0886-3350(00)00747-1

Cited by 126 publications

(42 citation statements)

References 42 publications

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“…Studies have shown that due to tackiness of acrylate material to posterior capsule the incidence of PCO is less. [1819]…”

Section: Discussionmentioning

confidence: 99%

Postoperative posterior capsular striae and the posterior capsular opacification in patients implanted with two types of intraocular lens material

Joshi

2017

Indian J Ophthalmol

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Aim:To evaluate the incidence of postoperative posterior capsular striae (PCS) and its influence on posterior capsular opacification (PCO) in patients implanted with two types of lens material.Setting:Tertiary eye care center in central rural India.Study Design:A prospective, observational, nonrandomized study.Materials and Methods:The study included 1247 patients having age-related cataract scheduled for removal by phacoemulsification technique and implantation of hydrophilic or hydrophobic intraocular lens (IOL). Demographic profile, nuclear grading, axial length, and IOL power were noted. Details of PCS were noted on the 1st postoperative day in patients with clear cornea. Postoperative follow-up was ensured to study the status of PCS and development of PCO.Results:The overall incidence of PCS was 19.8% (247 out of 1247 eyes). Out of 1247 patients, 641 patients (51.4%) had hydrophilic IOL implantation and 201 eyes had PCS (31.4%) and 606 patients (48.6%) had hydrophobic IOL implantation and 46 eyes had PCS (7.6%), P = 0.04. Three and more striae were seen in 119 eyes (119/641, 18.6%) in hydrophilic group and 4 eyes (4/606, 0.66%) in hydrophobic group. Sixty-two eyes (62/201, 30.9%) in hydrophilic group with multiple PCS were reported with persistent striae after 6 months of surgery. Two eyes in hydrophobic group had persistent striae even after 3 years of follow-up. Evaluation of PCO score of the hydrophilic group was 0.6 whereas of the hydrophobic group was 0.1 (P = 0.04). Ten patients of the hydrophilic group only required neodymium-doped yttrium aluminum garnet (ND: YAG) laser capsulotomy.Conclusion:The incidence of PCS was higher in hydrophilic than hydrophobic IOLs. Multiple PCS persisting in patients beyond 6 months after operation should be followed up for early development of PCO, particularly in patients implanted with hydrophilic IOL.

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“…Studies have shown that due to tackiness of acrylate material to posterior capsule the incidence of PCO is less. [1819]…”

Section: Discussionmentioning

confidence: 99%

Postoperative posterior capsular striae and the posterior capsular opacification in patients implanted with two types of intraocular lens material

Joshi

2017

Indian J Ophthalmol

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“…17 The Ra values of the posterior surface of the Hoya and Nidek IOLs only changed a little, while those of the Alcon IOLs increased. The Alcon Acrylof IOLs had a greater surface roughness, which may increase adhesion of proteins, such as fibronectin, to the optic surface, 18 resulting in an increase in the sticky nature and inducing adhesion of LECs 19 and collage membranes, 20 further leading to the prevention of posterior capsule opacification.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Biostability of Yellow and Clear Intraocular Lenses with a System Simulating Natural Intraocular Environment

Hayashi

Arai

et al. 2016

Trans. Vis. Sci. Tech.

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PurposeBlue light–filtering intraocular lenses (IOLs) are thought to protect the retina from blue light damage after cataract surgery, and the implantation of yellow-tinted IOLs has been commonly used in cataract surgery. To our knowledge, this is the first investigation measuring the long-term biostability of yellow-tinted IOLs using an in vitro system simulating natural intraocular environment.MethodsSix hydrophobic acrylic IOLs, three clear IOLs, and three yellow-tinted IOLs were included in the study. Each yellow-tinted IOL was a matching counterpart of a clear IOL, with the only difference being the lens color. The IOLs were kept in conditions replicating the intraocular environment using a perfusion culture system for 7 months. Resolution, light transmittance rate, and the modulation transfer function (MTF) were measured before and after culturing. Surface roughness of the anterior and posterior surfaces was also measured.ResultsAfter culturing for 7 months, there were no changes in the resolution, the light transmittance rate, and MTF. The surface roughness of the anterior and posterior surfaces increased after culturing; however, this increase was clinically insignificant. There were no differences in surface roughness between the clear and yellow-tinted IOLs, either before or after culturing.ConclusionsA novel in vitro system replicating intraocular environment was used to investigate the biostability of yellow-tinted IOLs. The surface roughness showed no clinically significant increase after culturing for 7 months.Translational RelevanceThis system is useful for evaluating the biostability of IOLs.

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“…Immunohistochemical study shows that this adhesion is mediated by fibronectin. [1011] Similarly, posterior capsule is also assumed to be adhered to the posterior surface of the IOL and bioadhesive nature of the IOL may act as an additional adhesive force. Residual cortical fibers and capsular ‘E’ cells are trapped initially within a sealed structure created by anterior capsular flap, posterior capsule, and edge of the IOL.…”

Section: Discussionmentioning

confidence: 99%

Liquefied after cataract and its surgical treatment

Bhattacharjee

et al. 2014

Indian J Ophthalmol

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Aims:To describe liquefied after cataract (LAC) and its surgical management following an uneventful phacoemulsification with posterior chamber in-the-bag intraocular lens (IOL) implantation and continuous curvilinear capsulorrhexis (CCC).Design:Interventional case series.Materials and Methods:Eleven patients with LAC, following uneventful phacoemulsification with CCC and in-the-bag IOL implantation were enrolled. After the basic slit lamp examination, each case was investigated with Scheimpflug photography and ultrasound biomicroscopy (UBM). Each case was treated with capsular lavage. Biochemical composition of the milky fluid was evaluated and ring of anterior capsular opacity (ACO) was examined under electron microscope.Results:All 11 cases presented with blurring of vision after 6-8 years of cataract surgery with IOL implantation. All cases had IOL microvacuoles, 360° anterior capsule, and anterior IOL surface touch along with ACO, ring of Soemmering, and posterior capsule distension filled with opalescent milky fluid with whitish floppy or crystalline deposits. Biochemically, the milky fluid contained protein (800 mg/dl), albumin (100 mg/dl), sugar (105 mg/dl), and calcium (0.13%) and was bacteriologically sterile. Histologically, the dissected ACO showed fibrous tissue. All cases were successfully treated with capsular lavage with good visual recovery and with no complication. There was no recurrence of LAC during 2 years postoperative follow-up in any of the cases.Conclusions:LAC is a late complication of standard cataract surgery. It may be a spectrum of capsular bag distension syndrome (CBDS) without shallow anterior chamber and secondary glaucoma. Capsular bag lavage is a simple and effective treatment for LAC and a safe alternative to neodymium-doped yttrium aluminum garnet (Nd-YAG) capsulotomy.

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Adhesion of fibronectin, vitronectin, laminin, and collagen type IV to intraocular lens materials in pseudophakic human autopsy eyes

Cited by 126 publications

References 42 publications

Postoperative posterior capsular striae and the posterior capsular opacification in patients implanted with two types of intraocular lens material

Postoperative posterior capsular striae and the posterior capsular opacification in patients implanted with two types of intraocular lens material

Evaluating the Biostability of Yellow and Clear Intraocular Lenses with a System Simulating Natural Intraocular Environment

Liquefied after cataract and its surgical treatment

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