Adhesive arachnoiditis in mixed connective tissue disease: a rare neurological manifestation

Khan, Maria Usman; Devlin, J; Fraser, Alexander

doi:10.1136/bcr-2016-217418

Cited by 7 publications

(15 citation statements)

References 19 publications

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“…The spinal cord lesions from the pugs with thoracolumbar myelopathy in this study shared many features with the spinal cord of laboratory dogs, used in research about adhesive, also called constrictive, arachnoiditis . Adhesive arachnoiditis, a rare chronic myelopathy in people, is characterized by meningeal fibrosis that has been described to cause disruption of the vascular supply and the development of arachnoid diverticula, syringomyelia and myelomalacia . Familiar adhesive arachnoiditis, with a suggested genetic influence, has been described .…”

Section: Discussioncontrasting

confidence: 38%

“…39,40 Adhesive arachnoiditis, a rare chronic myelopathy in people, is characterized by meningeal fibrosis that has been described to cause disruption of the vascular supply and the development of arachnoid diverticula, syringomyelia and myelomalacia. [41][42][43][44][45][46] Familiar adhesive arachnoiditis, with a suggested genetic influence, has been described. [47][48][49] In process dysplasias, are difficult to document without CT. 3 Although a previous study, including pugs of similar age as in the present study, could not confirm an association between CVMs and neurological signs, it has been suggested that some CVMs in pugs are indeed clinically significant.…”

Section: Macroscopic Findingsmentioning

confidence: 99%

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Thoracolumbar meningeal fibrosis in pugs

Rohdin

Ljungvall

Häggström

et al. 2020

Veterinary Internal Medicne

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Background Thoracolumbar myelopathies associated with spinal cord and vertebral column lesions, with a similar clinical phenotype, but different underlying etiologies, occur in pugs. Objectives To further characterize the clinical and neuropathological characteristics of pugs with longstanding thoracolumbar myelopathy. Animals Thirty client‐owned pure‐bred pugs with a history of more than a month of ataxia and paresis of the pelvic limbs, suggesting a myelopathy localized to the thoracolumbar spinal cord, were included in the study. Methods Prospective clinicopathological study. Included pugs underwent a complete neurological examination and gross and histopathologic postmortem studies with focus on the spinal cord. Computed tomography (n = 18), magnetic resonance imaging (n = 17), and cerebrospinal fluid analysis (n = 27) were performed before or immediately after death. Results Twenty male and 10 female pugs had a median age at clinical onset of 84 months (interquartile range, 66‐96). Affected pugs presented with a progressive clinical course and 80% were incontinent. There was circumferential meningeal fibrosis with concomitant focal, malacic, destruction of the neuroparenchyma in the thoracolumbar spinal cord in 24/30 pugs. Vertebral lesions accompanied the focal spinal cord lesion, and there was lympho‐histiocytic inflammation associated or not to the parenchymal lesion in 43% of the pugs. Conclusions and Clinical Importance Meningeal fibrosis with associated focal spinal cord destruction and neighboring vertebral column lesions were common findings in pugs with long‐standing thoracolumbar myelopathy.

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Section: Discussioncontrasting

confidence: 38%

Section: Macroscopic Findingsmentioning

confidence: 99%

Thoracolumbar meningeal fibrosis in pugs

Rohdin

Ljungvall

Häggström

et al. 2020

Veterinary Internal Medicne

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“…The female ‐to‐male ratio is 9:1, and no significant geographical distribution of the disease has been noted . Ten percent of MCTD patients have reported trigeminal neuropathy .…”

Section: Mixed Connective Tissue Diseasementioning

confidence: 99%

“…Trigeminal neuralgia‐like pain and isolated trigeminal sensory neuropathy have been reported in MCTD, with features suggestive of SS . Sudden pain and numbness have been reported as one of the first manifestations of MCTD presenting unilateral or bilaterally and have variable prognosis . Neurovascular headache is also a relatively common comorbidity .…”

Section: Mixed Connective Tissue Diseasementioning

confidence: 99%

Systemic considerations for orofacial neuropathy

Tiwari

Alsarraf

Yeoh³

et al. 2018

Aust Endodontic J

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Patients with orofacial neuropathic pain typically present with symptoms first hand to their general dental practitioner. It is important dental practitioners recognise the clinical presentations of these conditions for prompt diagnosis and appropriate management. This review will focus on the systemic causes of orofacial neuropathy. Infectious and autoimmune diseases with orofacial neuropathic manifestations such as post-herpetic neuralgia, paroxysmal neuralgias, painful trigeminal sensory neuropathies, peripheral neuritis and oral dysaesthesia will be discussed. Specifically, the prevalence, pathophysiology, clinical presentations and management of these conditions will be reviewed. Post-herpetic neuralgiaPost-herpetic neuralgia (PHN) is a chronic neuropathic pain condition persisting 3 months or greater following reactivation of varicella zoster virus (3). This peripheral system neuropathy results from damage to nervous tissue secondary to a herpes zoster attack. It is the most common neuropathic pain resulting from infection (4).Post-herpetic neuralgia has the potential to cause longterm severe pain, contributing to marked psychosocial dysfunction in the form of impaired sleep, decreased appetite and diminished libido (3,5). The impact of this condition can be drastic enough to transform independent living to dependent care (5).

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“…En los senos venosos, sobre todo el superior, su reabsorción tiene lugar en forma pasiva, dependiente del gradiente de presión del espacio subaracnoideo y de los propios senos (diferencial de presión de 5-7 mmHg 5 . La aracnoiditis basal es un proceso inflamatorio meníngeo y del espacio subaracnoideo que produce engrosamiento de éstos, así como adhesiones de la duramadre que causan complicaciones, entre ellas aracnoiditis adhesiva, neuropatías, mielopatías y radiculopatías 6 .…”

Section: Introductionunclassified

Evaluación de la velocidad del LCR en pacientes con neuroinfección y RM en contraste de fase

Saldaña-Sánchez¹,

Amezcua-Herrera²,

Vega-Gutiérrez³

2021

ARM

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La resonancia magnética en contraste de fase permite estudiar la dinámica del líquido cefalorraquídeo (LCR) de manera cualitativa y cuantitativa. Material y métodos: Se realizó un estudio retrospectivo y descriptivo con una muestra de 25 estudios, de los cuales 13 se efectuaron en pacientes sanos y 12 tenían datos de neuroinfección, hasta un 91.7% secundario a tuberculosis meníngea. Resultados: La media de velocidad del LCR en pacientes con neuroinfección fue de 2.549 cm/s (0.573-5.200) en comparación con los individuos sanos con media de 2.882 cm/s (1.0-6.420). Conclusiones: Al analizar las diferencias de medias en cm/s no se identificó diferencia significativa (p = 0.614) con 95% de intervalo de confianza. Palabras clave:Resonancia magnética en contraste de fase. Líquido cefalorraquídeo. Neuroinfección. Tuberculosis meníngea.

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Adhesive arachnoiditis in mixed connective tissue disease: a rare neurological manifestation

Cited by 7 publications

References 19 publications

Thoracolumbar meningeal fibrosis in pugs

Thoracolumbar meningeal fibrosis in pugs

Systemic considerations for orofacial neuropathy

Evaluación de la velocidad del LCR en pacientes con neuroinfección y RM en contraste de fase

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