Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full‐Thickness Skin Regeneration During Wound Healing

Abstract

Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full‐thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid‐graft‐dopamine and reduced graphene oxide (rGO) using a H2O2/HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. The polydopamine endowed antioxidant activity, tissue adhesiveness and hemostatic ability, self‐healing ability, conductivity, and NIR irradiation enhanced in vivo antibacterial behavior of the hydrogels are investigated. Moreover, drug release and zone of inhibition tests confirm sustained drug release capacity of the hydrogels. Furthermore, the hydrogel dressings significantly enhance vascularization by upregulating growth factor expression of CD31 and improve the granulation tissue thickness and collagen deposition, all of which promote wound closure and contribute to a better therapeutic effect than the commercial Tegaderm films group in a mouse full‐thickness wounds model. In summary, these adhesive hemostatic antioxidative conductive hydrogels with sustained drug release property to promote complete skin regeneration are an excellent wound dressing for full‐thickness skin repair.

PTH Derivative promotes wound healing via synergistic multicellular stimulating and exosomal activities

“…Endothelial cells and epithelial cells attach within or on the scaffold and form capillaries and the dermal layer. The capillaries supply oxygen and nutrients to the fibrocytes and epithelial cells, whereas the dermal layer protects the corium layer from bacteria and radiation [13]. These three cell types communicate and interact with one another via paracrine actions [14].…”

A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing

“…Moisture maintenance is necessary for the management of wounds. The hydrogel dressings could not only provide a moist environment but could also provide other multiple functions, such as anti-infective, antioxidative, and free radical scavenging capacities to promote wound healing [38][39][40] . However, most hydrogels do not have the ability to provide wound occlusion and stimulate blood vessel formation, which are important for chronic wound healing.…”

Conductive polymeric biomaterials for tissue regeneration applications

“…组织工程支架与宿主细 胞之间的相互作用还可通过调节支架的理化特性进行 调控, 如机械刚度、弹性、表面形貌和润湿性等 [6] . 陶瓷 [7] 、生物大分子 [8,9] 和合成聚合物 [10,11] [12~15] . 然而 上述材料均为非导电材料, 无法对电刺激产生响应, 从 而无法进一步模拟细胞外基质特性以调节细胞的生理 活动, 如促进细胞增殖、诱导分化和促进组织再生 [16] .…”