“…Overall, 3 studies had low risk, [ 34 , 38 , 40 ] 6 studies had unclear risk, [ 32 , 33 , [35] , [36] , [37] , 39 ] and 13 studies had high risk of bias [ [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] ] The risk of bias for the 14 included comparative observational studies was assessed using the NOS scale [ 14 ]. Overall, 13 of the 14 studies were of moderate to high quality (6-7 or 8-9 stars, respectively) [ [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] ], and 2 received 5 stars [ 53 , 54 ] ( Supplement Table 2 ).…”