Adipocyte Biology

Trayhurn, Paul; Frse,

doi:10.1002/9781444307627.ch9

Cited by 2 publications

(1 citation statement)

References 121 publications

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“…A origem da associação da obesidade e do processo inflamatório foi fortalecida após a descoberta de que muitas citocinas, definidas como proteínas solúveis sintetizadas que mediam a comunicação intracelular (WEIR e STEWART, 2002) e elevados níveis de proteínas de fase aguda, associadas à inflamação, são observados em indivíduos obesos. Os adipócitos são capazes de secretar diversas citocinas e proteínas responsáveis por elevar a produção de fatores associados à inflamação (TRAYHURN, 2009;BULLÓ et al, 2003).…”

Section: Obesidadeunclassified

O efeito da obesidade pré-gestacional sobre a proliferação de linfócitos do colostro humano e mecanismos intracelulares de modulação linfocitária na presença de adiponectina, leptina e melatonina

Pereira

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O efeito da obesidade pré-gestacional sobre a proliferação de linfócitos do colostro humano e mecanismos intracelulares de modulação linfocitária na presença de adiponectina, leptina e melatonina SÃO PAULO 2023 GABRIELLE DO AMARAL VIRGINIO PEREIRA O efeito da obesidade pré-gestacional sobre a proliferação de linfócitos do colostro humano e mecanismos intracelulares de modulação linfocitária na presença de adiponectina, leptina e melatonina

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Section: Obesidadeunclassified

O efeito da obesidade pré-gestacional sobre a proliferação de linfócitos do colostro humano e mecanismos intracelulares de modulação linfocitária na presença de adiponectina, leptina e melatonina

Pereira

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Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Its Association with Developing Obesity and Diabetes Mellitus: A Narrative Review

Alharbi

Algonaiman

Alduwayghiri

et al. 2022

IJERPH

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Bisphenol A, a well-known endocrine-disrupting chemical, has been replaced with its analogs bisphenol S (BPS) and bisphenol F (BPF) over the last decade due to health concerns. BPS and BPF are present in relatively high concentrations in different products, such as food products, personal care products, and sales receipts. Both BPS and BPF have similar structural and chemical properties to BPA; therefore, considerable scientific efforts have investigated the safety of their exposure. In this review, we summarize the findings of relevant epidemiological studies investigating the association between urinary concentrations of BPS and/or BPF with the incidence of obesity or diabetes. The results showed that BPS and BPF were detected in many urinary samples at median concentrations ranging from 0.03 to 0.4 µg·L−1. At this exposure level, BPS median urinary concentrations (0.4 µg·L−1) were associated with the development of obesity. At a lower exposure level (0.1–0.03 µg·L−1), two studies showed an association with developing diabetes. For BPF exposure, only one study showed an association with obesity. However, most of the reported studies only assessed BPS exposure levels. Furthermore, we also summarize the findings of experimental studies in vivo and in vitro regarding our aim; results support the possible obesogenic effects/metabolic disorders mediated by BPS and/or BPF exposure. Unexpectedly, BPS may promote worse obesogenic effects than BPA. In addition, the possible mode of action underlying the obesogenic effects of BPS might be attributed to various pathophysiological mechanisms, including estrogenic or androgenic activities, alterations in the gene expression of critical adipogenesis-related markers, and induction of oxidative stress and an inflammatory state. Furthermore, susceptibility to the adverse effects of BPS may be altered by sex differences according to the results of both epidemiological and experimental studies. However, the possible mode of action underlying these sex differences is still unclear. In conclusion, exposure to BPS or BPF may promote the development of obesity and diabetes. Future approaches are highly needed to assess the safety of BPS and BPF regarding their potential effects in promoting metabolic disturbances. Other studies in different populations and settings are highly suggested.

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Adipocyte Biology

Cited by 2 publications

References 121 publications

O efeito da obesidade pré-gestacional sobre a proliferação de linfócitos do colostro humano e mecanismos intracelulares de modulação linfocitária na presença de adiponectina, leptina e melatonina

O efeito da obesidade pré-gestacional sobre a proliferação de linfócitos do colostro humano e mecanismos intracelulares de modulação linfocitária na presença de adiponectina, leptina e melatonina

Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Its Association with Developing Obesity and Diabetes Mellitus: A Narrative Review

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