Adipocyte Rnf20 ablation increases the fast-twitch fibers of skeletal muscle via lysophosphatidylcholine 16:0

Zhao, Ying; Chen, Chuanhe; Pan, Jianfei; Lam, Sin Man; Shui, Guanghou; Yang, Shulin; Wu, Tianwen; Cong, Tao; Zhao, Jianguo; Wang, Yanfang

doi:10.1007/s00018-023-04896-4

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…Figure 2b shows the separation of NLs, which included TAGs, FFAs, and DAGs. DAG and TAG levels were found to be increased, which was consistent with previous findings (Zhao et al, 2023).…”

Section: Characteristic Features Of Palmitate-treated C2c12 Myotubessupporting

confidence: 92%

“…PtdCho showed a trend similar to that of PtdEtn, and the level of the most abundant molecular species in the myotubes, PtdCho (16:1_18:1), decreased significantly (Figure 5b). The induction of LPtdCho synthesis represents one of the triggers of inflammation, which is increased upon exercise and associated with muscle hypertrophy (Zhao et al, 2023). LPtdCho production is decreased in individuals with obesity (Ferrara et al, 2021).…”

Section: Detailed Lipid Analyses Of Molecular Species Using Lc-ms/msmentioning

confidence: 99%

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A lipidomics approach reveals novel phospholipid changes in palmitate‐treated C2C12 myotubes

Tawara,

Morisasa,

Mukai

et al. 2024

Lipids

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Type 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disorder. Insulin resistance and oxidative stress are associated with T2DM development. The hypothesis that patients with T2DM show excess accumulation of lipids, such as ceramides (Cers) and diacylglycerols (DAGs), in their skeletal muscles has been widely supported; however, detailed lipidomic data at the molecular species level are limited. Therefore, in this study, we aimed to investigate the in vitro dynamics of total lipids, including phospholipids (PLs), sphingolipids, and neutral lipids, in palmitic acid‐induced insulin‐resistant C2C12 skeletal muscle cells. Our data demonstrated that the profiles of not only Cers and DAGs but also those of PLs showed considerably differences after palmitate treatment. We found that PL synthesis reduced and PL degradation increased after palmitate treatment. These findings may aid in the development of treatments to ameliorate muscle dysfunction caused by lipid accumulation in muscles.

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“…Figure 2b shows the separation of NLs, which included TAGs, FFAs, and DAGs. DAG and TAG levels were found to be increased, which was consistent with previous findings (Zhao et al, 2023).…”

Section: Characteristic Features Of Palmitate-treated C2c12 Myotubessupporting

confidence: 92%

Section: Detailed Lipid Analyses Of Molecular Species Using Lc-ms/msmentioning

confidence: 99%

A lipidomics approach reveals novel phospholipid changes in palmitate‐treated C2C12 myotubes

Tawara,

Morisasa,

Mukai

et al. 2024

Lipids

View full text Add to dashboard Cite

show abstract

The influence of biological sex in human skeletal muscle transcriptome during ageing

Huang,

Chen,

Xiao

et al. 2023

Biogerontology

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Adipocyte Rnf20 ablation increases the fast-twitch fibers of skeletal muscle via lysophosphatidylcholine 16:0

Cited by 2 publications

References 46 publications

A lipidomics approach reveals novel phospholipid changes in palmitate‐treated C2C12 myotubes

A lipidomics approach reveals novel phospholipid changes in palmitate‐treated C2C12 myotubes

The influence of biological sex in human skeletal muscle transcriptome during ageing

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