Adipokine Protein Expression Pattern in Growth Hormone Deficiency Predisposes to the Increased Fat Cell Size and the Whole Body Metabolic Derangements

Ukropec, Jozef; Penesová, Adela; Škopková, Martina; Pura, Mikuláš; Vlček, Miroslav; Rádiková, Žofia; Imrich, Richard; Ukropcová, Barbara; Tajtáková, M; Koška, Juraj; Zórad, Štefan; Белан, В. Н.; Vaňuga, Peter; Payer, Juraj; Eckel, Jürgen; Klimeš, I; Gašperíková, Daniela

doi:10.1210/jc.2007-2188

Cited by 46 publications

(34 citation statements)

References 37 publications

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“…Apart from approximately 50% of mature lipid-laden adipocytes it contains various stromal cells including preadipocytes, endothelial cells, fibroblasts, pluripotent stem cells and immune cells which substantially influence its function (Bjorntorp 1974;Sethi & Vidal-Puig 2007;Divoux & Clement 2011). Extreme enlargement of the fat cell size, such as we have recently observed in individuals with growth hormone deficiency, is perhaps the best early marker of the obesity relatedmetabolic disease development (Ukropec et al 2008a) (Fig. 1.).…”

Section: Adipose Tissue In Metabolic Health and Diseasementioning

confidence: 96%

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Adipose Tissue and Skeletal Muscle Plasticity in Obesity and Metabolic Disease

Ukropec¹,

Ukropcová²

2012

Dyslipidemia - From Prevention to Treatment

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Section: Adipose Tissue In Metabolic Health and Diseasementioning

confidence: 96%

“…1. Fat cell size in obesity and in growth hormone deficiency (GHD), percentage of cumulative frequency (Y axis), (Ukropec et al 2008a). …”

Section: Adipose Tissue In Metabolic Health and Diseasementioning

confidence: 99%

Adipose Tissue and Skeletal Muscle Plasticity in Obesity and Metabolic Disease

Ukropec¹,

Ukropcová²

2012

Dyslipidemia - From Prevention to Treatment

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“…All these hormonal factors themselves act in interaction: for instance, GH deficiency modulates adipokine and cytokine protein expression pattern, which might influence adipose tissue growth and differentiation and predispose to a defect in the whole-body insulin action (Ukropec et al, 2008a). While it was originally thought that adiponectin expression was limited to adipocytes, it is also expressed in mouse skeletal muscles and within differentiated L6 myotubes.…”

Section: Endocrine and Metabolic Regulation Of Muscle Physiology Befomentioning

confidence: 99%

Endocrine and metabolic regulation of muscle growth and body composition in cattle

Hocquette

2010

Animal

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Muscle metabolism (in interaction with other organs and tissues, including adipose tissue) plays an important role in the control of growth and body composition. Muscle ontogenesis has been described in different genotypes of cattle for myofibres, connective tissue and intramuscular depots. The ontogenesis or the action of putatively important factors controlling muscle development (IGF-II expression, IGF receptors, growth hormone (GH) receptor, myostatin, basic fibroblast growth factor, transforming growth factor-b1, insulin and thyroid hormones) has also been studied on bovine foetal muscle samples and satellite cells. The glucose/ insulin axis has been specifically studied in both the bovine adipose tissue and heart. Clearly, cattle, like sheep, are mature species at birth based on their muscle characteristics compared to other mammalian or farm animal species. The different myoblast generations have been well characterised in cattle, including the second generation which is liable to be affected by foetal undernutrition at least in sheep. Interesting genotypes, for example, double-muscled genotype, have been characterised by an altered metabolic and endocrine status associated with a reduced fat mass, specific muscle traits and different foetal characteristics. Finally, the recent development of genomics in cattle has allowed the identification of novel genes controlling muscle development during foetal and postnatal life. Generally, a high muscle growth potential is associated with a reduced fat mass and a switch of muscle fibres towards the glycolytic type. The possibility and the practical consequences of manipulating muscle growth and, hence, body composition by nutritional and hormonal factors are discussed for bovines based on our current biological knowledge.

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“…[1][2][3][4] Common obesity and metabolic syndrome are frequently associated with decreased levels of circulating GH and some beneficial effects of low-dose GH treatment to obese individuals with relative GH deficiency were reported. [5][6][7] Long-term GH supplementation to GH deficient adults has been shown to reverse some of the negative metabolic consequences of GH deficiency and reduce metabolic and cardiovascular morbidity among these patients.…”

Section: Introductionmentioning

confidence: 99%

Improved adipose tissue metabolism after 5-year growth hormone replacement therapy in growth hormone deficient adults: The role of zinc-α2-glycoprotein

et al. 2014

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Adipokine Protein Expression Pattern in Growth Hormone Deficiency Predisposes to the Increased Fat Cell Size and the Whole Body Metabolic Derangements

Abstract: Our data demonstrate that GHD modulates adipokine and cytokine protein expression pattern, which might influence the adipose tissue growth and differentiation and predispose to tissue hypoxia, inflammation, and a defect in the whole-body insulin action.

Cited by 46 publications

References 37 publications

Adipose Tissue and Skeletal Muscle Plasticity in Obesity and Metabolic Disease

Adipose Tissue and Skeletal Muscle Plasticity in Obesity and Metabolic Disease

Endocrine and metabolic regulation of muscle growth and body composition in cattle

Improved adipose tissue metabolism after 5-year growth hormone replacement therapy in growth hormone deficient adults: The role of zinc-α2-glycoprotein

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