Adipokines change the balance of proliferation/apoptosis in the ovarian cells of human and domestic animals: A comparative review

Kurowska, Patrycja; Mlyczyńska, Ewa; Dawid, Monika; Sierpowski, M; Estienne, Anthony; Dupont, Joëlle; Rak, Agnieszka

doi:10.1016/j.anireprosci.2021.106737

Cited by 12 publications

(13 citation statements)

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“…The chemerin system has been studied in model organisms such as mice and rats, as well as humans. In addition, there are data on the chemerin system in cattle, pigs, and chickens [ 21 ].…”

Section: Chemerin System Evolutionmentioning

confidence: 99%

Chemerin Forms: Their Generation and Activity

2022

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Chemerin is the product of the RARRES2 gene which is secreted as a precursor of 143 amino acids. That precursor is inactive, but proteases from the coagulation and fibrinolytic cascades, as well as from inflammatory reactions, process the C-terminus of chemerin to first activate it and then subsequently inactivate it. Chemerin can signal via two G protein-coupled receptors, chem1 and chem2, as well as be bound to a third non-signaling receptor, CCRL2. Chemerin is produced by the liver and secreted into the circulation as a precursor, but it is also expressed in some tissues where it can be activated locally. This review discusses the specific tissue expression of the components of the chemerin system, and the role of different proteases in regulating the activation and inactivation of chemerin. Methods of identifying and determining the levels of different chemerin forms in both mass and activity assays are reviewed. The levels of chemerin in circulation are correlated with certain disease conditions, such as patients with obesity or diabetes, leading to the possibility of using chemerin as a biomarker.

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“…The chemerin system has been studied in model organisms such as mice and rats, as well as humans. In addition, there are data on the chemerin system in cattle, pigs, and chickens [ 21 ].…”

Section: Chemerin System Evolutionmentioning

confidence: 99%

Chemerin Forms: Their Generation and Activity

2022

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“…Уровень ФНО-α возрастает при ожирении, у пациентов с СПЯ, и снижается с потерей массы тела [8]. Референсное значение ФНО-α -менее 8,1 пг/мл, однако высокие значения данного показателя неспецифичны и наблюдаются при множестве состояний [12].…”

Section: адипокины как регуляторы овариальной функции при ожиренииunclassified

“…Лептин участвует в различных аспектах функции яичников, включая созревание фолликулов, развитие ооцитов, стероидогенез [28], а его рецепторы экспрессируются в клетках гранулезы и теки, ооцитах и эндотелиальных клетках кровеносных сосудов яичников [29]. Некоторые авторы считают источником лептина в лютеиновой фазе желтое тело [30].…”

Section: адипокины как регуляторы овариальной функции при ожиренииunclassified

Adipokinesand Ghrelin Rolein Regulation of Ovarian Function in Obesity

et al. 2022

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There is a great worldwide trend in the incidence of obesity, which is increasing with each passing year among all populations, including women of reproductive age. Given the impressive list of diseases associated with obesity, as well as the negative inverse correlation of the severity of obesity with fertility, this problem is global not only in the social sphere, but it also becomes demographically significant.Along with other pathogenetic mechanisms leading to persistent anovulation, an imbalance in adipokine production by adipose tissue can also serve as one of the important links in the development of reproductive dysfunction. Despite apparent interest in this topic, a large number of previously discovered adipokines are still not studied. Among adipokines, the effects of adiponectin and leptin on reproductive function are best known. Alterations in adiponectin and leptin levels can affect hypothalamic-pituitary-gonadal signaling, folliculogenesis, oogenesis and steroidogenesis. In addition, leptin is involved in the initiation of puberty, regulation of the menstrual cycle, and changes the balance between proliferation and apoptosis in ovarian cells. The leading causes of reduced fertility, infertility, and IVF failure in obese patients are mechanisms that promote the formation of chronic anovulation, delay the maturation of oocytes, reduce their quality, and/or lead to changes in endometrial susceptibility. These effects can be caused by an imbalance in the concentrations of leptin and adiponectin (leptin excess and adiponectin deficiency), lead to endometrial dysfunction, disruption of implantation and early embryogenesis. These changes, in turn, can affect just as the likelihood of spontaneous conception, so the effectiveness of assisted reproductive technologies and subsequent gestation.Thus, the study of potential pathogenetic pathways of fertility regulation in obesity, one of which is the subject of this review, is an important area for further study.

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“…However, studies over the past 10 years have demonstrated the importance of other adipokines produced by adipose tissue, such as adiponectin, resistin, chemerin, visfatin and apelin, in the regulation of bovine ovarian function (Fig. 4; Kurowska et al 2021).…”

Section: Adipokines As Mediators Of Nutritional and Metabolic Input To The Follicle: The Adipokinomementioning

confidence: 99%

The ovarian follicle of ruminants: the path from conceptus to adult

Juengel

Cushman²,

Dupont

et al. 2021

Reprod. Fertil. Dev.

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This review resulted from an international workshop and presents a consensus view of critical advances over the past decade in our understanding of follicle function in ruminants. The major concepts covered include: (1) the value of major genes; (2) the dynamics of fetal ovarian development and its sensitivity to nutritional and environmental influences;(3) the concept of an ovarian follicle reserve, aligned with the rise of anti-Müllerian hormone as a controller of ovarian processes; (4) renewed recognition of the diverse and important roles of theca cells; (5) the importance of follicular fluid as a microenvironment that determines oocyte quality; (6) the 'adipokinome' as a key concept linking metabolic inputs with follicle development; and (7) the contribution of follicle development to the success of conception. These concepts are important because, in sheep and cattle, ovulation rate is tightly regulated and, as the primary determinant of litter size, it is a major component of reproductive efficiency and therefore productivity. Nowadays, reproductive efficiency is also a target for improving the 'methane efficiency' of livestock enterprises, increasing the need to understand the processes of ovarian development and folliculogenesis, while avoiding detrimental trade-offs as greater performance is sought.

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Adipokines change the balance of proliferation/apoptosis in the ovarian cells of human and domestic animals: A comparative review

Cited by 12 publications

References 98 publications

Chemerin Forms: Their Generation and Activity

Chemerin Forms: Their Generation and Activity

Adipokinesand Ghrelin Rolein Regulation of Ovarian Function in Obesity

The ovarian follicle of ruminants: the path from conceptus to adult

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