Adiponectin: A Promising Target for the Treatment of Diabetes and Its Complications

Begum, Mahmuda; Choubey, Mayank; Tirumalasetty, Munichandra Babu; Arbee, Shahida; Mohib, Mohammad Mohabbulla; Wahiduzzaman, Md; Mamun, Mohammed A.; Uddin, Mohammad Borhan; Mohiuddin, Mohammad Sarif

doi:10.3390/life13112213

Cited by 21 publications

(6 citation statements)

References 107 publications

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“…46 Hence, adiponectin can be regarded a promising target for the prevention and remedy of metabolic disorders such as obesity, and type 2 diabetes. 47 In the present study, the enhancement of adiponectin by LAX represented another mechanism for impeding lipid accumulation and ameliorating glucose metabolism dysfunction. A significant difference in serum adiponectin between LAX and AX could potentially explain why LAX more effectively inhibits visceral fat deposition than AX.…”

Section: Contentsmentioning

confidence: 63%

Lactobacillus casei‐fermented Amomum xanthioides ameliorates metabolic dysfunction in high‐fat diet‐induced obese mice

Wang,

Hwang,

Choi

et al. 2024

The FASEB Journal

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Amomum xanthioides (AX) has been used as an edible herbal medicine to treat digestive system disorders in Asia. Additionally, Lactobacillus casei is a well‐known probiotic commonly used in fermentation processes as a starter. The current study aimed to investigate the potential of Lactobacillus casei‐fermented Amomum xanthioides (LAX) in alleviating metabolic disorders induced by high‐fat diet (HFD) in a mouse model. LAX significantly reduced the body and fat weight, outperforming AX, yet without suppressing appetite. LAX also markedly ameliorated excessive lipid accumulation and reduced inflammatory cytokine (IL‐6) levels in serum superior to AX in association with UCP1 activation and adiponectin elevation. Furthermore, LAX noticeably improved the levels of fasting blood glucose, serum insulin, and HOMA‐IR through positive regulation of glucose transporters (GLUT2, GLUT4), and insulin receptor gene expression. In conclusion, the fermentation of AX demonstrates a pronounced mitigation of overnutrition‐induced metabolic dysfunction, including hyperlipidemia, hyperglycemia, hyperinsulinemia, and obesity, compared to non‐fermented AX. Consequently, we proposed that the fermentation of AX holds promise as a potential candidate for effectively ameliorating metabolic disorders.

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Section: Contentsmentioning

confidence: 63%

Lactobacillus casei‐fermented Amomum xanthioides ameliorates metabolic dysfunction in high‐fat diet‐induced obese mice

Wang,

Hwang,

Choi

et al. 2024

The FASEB Journal

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“…Adiponectin, the most prevalent peptide released by adipocytes, plays a prominent role in the intricate connection between adiposity and insulin resistance. Both animal and experimental research have demonstrated that adiponectin enhances insulin sensitivity, suggesting that it may serve as a preventive measure against the onset of T2DM ( 7 , 22 , 23 ). An observational study exploring the relationship between protein, specifically IGFBP2, and diabetes suggested an inverse association.…”

Section: Discussionmentioning

confidence: 99%

Mendelian randomization analysis demonstrates the causal effects of IGF family members in diabetes

Li,

Tang,

Lin

et al. 2024

Front. Med.

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BackgroundObservational studies have consistently shown significant associations between the IGF family and metabolic diseases, including diabetes. However, these associations can be influenced by confounding factors and reverse causation. This study aimed to assess the causal relationship between the IGF family and diabetes using Mendelian randomization (MR).MethodsWe conducted a two-sample MR analysis to investigate the causal effects of the IGF family on diabetes. Instrumental variables for the IGF family and diabetes were derived from summary-level statistics obtained from genome-wide association studies. Horizontal pleiotropy was assessed using MR-Egger regression and the weighted median method. We applied the inverse-variance weighted method as part of the conventional MR analysis to evaluate the causal impact of the IGF family on diabetes risk. To test the robustness of the results, we also employed MR-Egger regression, the weighted median method, and a leave-one-out analysis.ResultsOur study revealed that IGF-1 causally increases the risk of Type 2 Diabetes (T2D), while IGFBP-6, adiponectin and INSR decreases the risk (IGF-1, OR 1.02 [95% CI 1–1.03], p = 0.01; IGFBP-6, OR 0.92 [95% CI 0.87–0.98], p = 0.01; Adiponectin, OR 0.837 [95% CI 0.721–0.970], p = 0.018; INSR, OR 0.910 [95% CI 0.872–0.950], p = 1.52 × 10–5). Additionally, genetically lower levels of IGF-1 and IGFBP-5, along with higher levels of IGFBP-7, were associated with an increased risk of Type 1 Diabetes (T1D) (IGF-1, OR 0.981 [95% CI 0.963–0.999], p = 0.037; IGFBP-5, OR 0.882 [95% CI 0.778–0.999], p = 0.049; IGFBP-7, OR 1.103 [95% CI 1.008–1.206], p = 0.033).ConclusionIn summary, our investigation has unveiled causal relationships between specific IGF family members and T1D and T2D through MR analysis. Generally, the IGF family appears to reduce the risk of T1D, but it presents a more complex and controversial role in the context of T2D. These findings provide compelling evidence that T2D is intricately linked with developmental impairment. Our study results offer fresh insights into the pathogenesis and the significance of serum IGF family member concentrations in assessing diabetes risk.

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“…The glycemic levels of GK and Zucker (lean and diabetic) rats were markedly elevated when compared to those of the control rats. This shows that irrespective of the type of diabetes, hyperglycemia is a key and noxious sign of DM [ 2 , 38 ]. Hyperglycemia is the main trigger of OS, which stimulates a cascade of molecular events that leads to dyslipidemia, micro- and macrovascular complications associated with DM [ 39 , 40 , 41 , 42 , 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

High-Density Lipoprotein Is Located Alongside Insulin in the Islets of Langerhans of Normal and Rodent Models of Diabetes

Mohsin,

Elabadlah,

Alotaiba

et al. 2024

Nutrients

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Recent studies have implicated pre-beta and beta lipoproteins (VLDL and LDL) in the etiopathogenesis of complications of diabetes mellitus (DM). In contrast, alpha lipoprotein (HDL) is protective of the beta cells of the pancreas. This study examined the distribution of HDL in the islets of Langerhans of murine models of type 1 diabetic rats (streptozotocin (STZ)-induced DM in Wistar rats) and type 2 models of DM rats (Goto–Kakizaki (GK), non-diabetic Zucker lean (ZL), and Zucker diabetic and fatty (ZDF)). The extent by which HDL co-localizes with insulin or glucagon in the islets of the pancreas was also investigated. Pancreatic tissues of Wistar non-diabetic, diabetic Wistar, GK, ZL, and ZDF rats were processed for immunohistochemistry. Pancreatic samples of GK rats fed with either a low-fat or a high-fat diet were prepared for transmission immune-electron microscopy (TIEM) to establish the cytoplasmic localization of HDL in islet cells. HDL was detected in the core and periphery of pancreatic islets of Wistar non-diabetic and diabetic, GK, ZL, and ZDF rats. The average total of islet cells immune positive for HDL was markedly (<0.05) reduced in GK and ZDF rats in comparison to Wistar controls. The number of islet cells containing HDL was also remarkably (p < 0.05) reduced in Wistar diabetic rats and GK models fed on high-fat food. The co-localization study using immunofluorescence and TIEM techniques showed that HDL is detected alongside insulin within the secretory granules of β-cells. HDL did not co-localize with glucagon. This observation implies that HDL may contribute to the metabolism of insulin.

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Adiponectin: A Promising Target for the Treatment of Diabetes and Its Complications

Cited by 21 publications

References 107 publications

Lactobacillus casei‐fermented Amomum xanthioides ameliorates metabolic dysfunction in high‐fat diet‐induced obese mice

Lactobacillus casei‐fermented Amomum xanthioides ameliorates metabolic dysfunction in high‐fat diet‐induced obese mice

Mendelian randomization analysis demonstrates the causal effects of IGF family members in diabetes

High-Density Lipoprotein Is Located Alongside Insulin in the Islets of Langerhans of Normal and Rodent Models of Diabetes

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