Adiponectin: An Attractive Marker for Metabolic Disorders in Chronic Obstructive Pulmonary Disease (COPD)

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease which may be complicated by development of co-morbidities including metabolic disorders. Metabolic disorders commonly associated with this disease contribute to lung function impairment and mortality. Systemic inflammation appears to be a major factor linking COPD to metabolic alterations. Adipose tissue seems to interfere with systemic inflammation in COPD patients by producing a large number of proteins, known as “adipokines”, involved in various processes such as metabolism, immunity and inflammation. There is evidence that adiponectin is an important modulator of inflammatory processes implicated in airway pathophysiology. Increased serum levels of adiponectin and expression of its receptors on lung tissues of COPD patients have recently highlighted the importance of the adiponectin pathway in this disease. Further, in vitro studies have demonstrated an anti-inflammatory activity for this adipokine at the level of lung epithelium. This review focuses on mechanisms by which adiponectin is implicated in linking COPD with metabolic disorders.

Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work

“…The biological function of adipokines in lung diseases seems to be mainly related to the inflammatory process. In particular, the intercorrelation between adipose tissue and the lung has become evident as the involvement of adiponectin has been demonstrated in several lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), emphysema, and cancer [34]. In fact, with specific regard to COPD, a low-grade inflammatory state has been demonstrated [35][36][37].…”

The prevention and treatment of hypoadiponectinemia-associated human diseases by up-regulation of plasma adiponectin

“…457 Adiponectin was suggested as a novel marker for metabolic disorders 458 in COPD [10]. as heart functions deteriorated [122].…”

Effect of Ophiocephalus striatus Extract on the Levels of TNF-α, CRP, Leptin, Adiponectin, and COPD Assessment Test (CAT) Score in Stable COPD Patients with Muscle Wasting

“…Previous studies have also found that adiponectin inhibits transactivation of NF-κb and induces anti-inflammatory IL-10 through ERK1/2, as well as AKT through the mediation of AdipoR1. [3,17] Catfish extract contains natural complex nutrients, such as protein, albumin, vitamins, minerals, fatty acids, and 15 kinds of amino acids, including five essential amino acids. The current study found a significant decrease in leptin levels after administration of catfish extract.…”

“…A previous study indicated that adiponectin exerts its anti-inflammatory properties by inhibiting pro-inflammatory mediators (TNF-α, IL-6, ICAM-1 endothelial adhesion molecules, and nuclear factor-κβ) and promoting anti-inflammatory mediators (IL-10 and receptor antagonist IL-1). [3] The high prevalence of muscle wasting in COPD patients requires preventative and curative actions. Nutritional therapy in COPD patients is expected to provide an enhancement in body functions, one of which is an improvement in muscle strength.…”