Adiponectin and adiponectin receptor 1 expression proteins levels are modified in breast cancer in postmenopausal women with obesity

Abstract

AimTo analyse the expression of adiponectin (ADIPOQ), and its receptors ADIPOR1 and ADIPOR2, in breast cancer tissue of postmenopausal women with different body mass indexes (BMIs).Subjects and methodsOne hundred and fifty postmenopausal Mexican-Mestizo women with breast cancer were included. BMI was determined in each case. To carry out qualitative and semiquantitative assessments of protein expression by immunohistochemistry, the H-Score method was used, through ImageJ's IHC Profiler software. Statistical power of the study was >80% with a p<0.05.ResultsFifty women had a normal BMI, 50 presented overweight and 50 had obesity. The expression of ADIPOQ in breast cancer tissue of postmenopausal woman with normal BMI was higher in comparison to women with overweight or with obesity (p=0.002 and p<0.001, respectively). Furthermore, the expression of ADIPOR1 in breast cancer tissue of postmenopausal women with normal BMI was significantly lower when compared with women with overweight or with obesity (p=0.005 and p<0.001, respectively). Meanwhile, the expression of ADIPOR2 in breast cancer tissue, in the cytoplasm, was similar in all groups studied.ConclusionsWe found that women with overweight or obesity had a lower expression of ADIPOQ and a higher ADIPOR1 expression in breast cancer tissue, when compared with women with a normal BMI.

The impact of obesity and adipokines on breast and gynecologic malignancies

“…Adiponectin may also serve roles beyond insulin sensitization in breast cancer since increased adiponectin levels have been observed at earlier stages of the disease 73 . Studies have also identified lower expression of adiponectin in obese women with breast cancer in comparison to women with normal BMI 74,75 . The expression of adiponectin receptors 1 and 2 in breast cancer tissue as it relates to BMI is complicated as Orozco‐Arguelles et al.…”

“…recently demonstrated an increase in adiponectin receptor 1 in breast cancer tissue of women with higher BMI compared to those with normal BMI. This may reflect the upregulation of compensatory mechanisms in the setting of decreased adiponectin expression 74 . Increased adiponectin levels may be indicative of improved overall survival and disease‐free survival in breast cancer 73,76 .…”

“…73 Studies have also identified lower expression of adiponectin in obese women with breast cancer in comparison to women with normal BMI. 74,75 The expression of adiponectin receptors 1 and 2 in breast cancer tissue as it relates to BMI is complicated as Orozco-Arguelles et al recently demonstrated an increase in adiponectin receptor 1 in breast cancer tissue of women with higher BMI compared to those with normal BMI. This may reflect the upregulation of compensatory mechanisms in the setting of decreased adiponectin expression.…”

“…This may reflect the upregulation of compensatory mechanisms in the setting of decreased adiponectin expression. 74 Increased adiponectin levels may be indicative of improved overall survival and disease-free survival in breast cancer. 73,76 However, Obi et al found in a large cohort of women with breast cancer that doubling the adiponectin concentration is associated with increased breast cancer-specific mortality in ER-PR-breast cancer.…”

Altered Adipokine Expression in Tumor Microenvironment Promotes Development of Triple Negative Breast Cancer

“…Others found an association only in post-menopausal patients [ 113 ]. Adiponectin expression in breast cancer tissue is lower in obese women, when compared with normal BMI and overweight ones [ 114 ]. Expression of the receptors AdipoR1 and AdipoR2 is also deregulated in breast cancer [ 115 ].…”