Adiponectin and Leptin Gene Polymorphisms in Patients With Post-Transplant Diabetes Mellitus

Romanowski, M; Dziedziejko, Violetta; Maciejewska-Karłowska, Agnieszka; Sawczuk, Marek; Safranow, Krzysztof; Domański, Leszek; Pawlik, Andrzej

doi:10.2217/pgs.15.71

Cited by 35 publications

(30 citation statements)

References 36 publications

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“…A study by Romanowski et al47 conducted on 169 Caucasian patients (23 with PTDM) revealed an association between IL-17F SNP (rs763780) and PTDM. No significance was found for IL-17A polymorphism (rs2275913) and 2 other evaluated SNPs of IL-17F (rs11465553 and rs2397084) 47…”

Section: Genetic Polymorphisms and Risk Of Diabetes Mellitusmentioning

confidence: 99%

Genetic factors in pathogenesis of diabetes mellitus after kidney transplantation

Tarnowski¹,

Słuczanowska-Głąbowska²,

Pawlik³

et al. 2017

TCRM

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Posttransplant diabetes mellitus (PTDM) is one of the major metabolic complications after transplantation of solid organs including the kidney. This type of diabetes mellitus affects allograft survival, cardiovascular complications and overall patient survival. The modifiable risk factors that contribute to PTDM include obesity, some viral infections (eg, hepatitis C virus, cytomegalovirus) and especially immunosuppressive drugs including corticosteroids, tacrolimus, cyclosporine and sirolimus. Currently, predisposing genetic factors have been considered important in PTDM development. The commonly evaluated genetic determinants include genes encoding transcription factors, cytokines, chemokines, adipokines, ionic channels, glucose transporters, cytochrome P450 enzymes and other enzymes metabolizing drugs, drug transporters. Unfortunately, the results of studies are inconclusive and differ between populations. There is a need for large genome-wide association study to identify the genetic risk factors associated with PTDM development.

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Section: Genetic Polymorphisms and Risk Of Diabetes Mellitusmentioning

confidence: 99%

Genetic factors in pathogenesis of diabetes mellitus after kidney transplantation

Tarnowski¹,

Słuczanowska-Głąbowska²,

Pawlik³

et al. 2017

TCRM

Self Cite

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“…Leptin gene polymorphisms are associated with obesity, insulin resistance, and diabetes mellitus, as demonstrated in a study by (Romanowski et al, 2015). The association of polymorphisms in the leptin gene with GDM is controversial.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to regulating appetite and metabolism, this adipokine is important in insulin secretion (Romanowski et al, 2015). Insulin resistance is an important feature of gestational diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes

et al. 2017

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ABSTRACT. Leptin (LEP), a protein that plays a fundamental role in the metabolism of energy reserves, and the solute carrier family 30 A8 zinc transporter (SLC30A8) have been consistently associated with diabetes. Women with gestational diabetes are at moderate risk of developing diabetes type 1 and 2 after pregnancy, in addition to complications to the fetus. We investigated the association of the polymorphisms rs7799039 (LEP) and rs13266634 (SLC30A8) in a case-control study in Euro-Brazilians with gestational diabetes (GDM, N = 180). Realtime PCR with fluorescent probes (TaqMan system) was applied to genotyping. All polymorphisms were in Hardy-Weinberg equilibrium. The minor allele frequencies, for healthy and GDM, respectively, for the A-allele (LEP gene rs7799039) were 40.3% (95%CI = 35-45%) vs 36.6% (95%CI = 31-42%), P = 0.345; and for the T-allele (SLC30A8 gene rs13266634) were 27.8% (95%CI = 23-32%) vs 23.5% (95%CI = 18-29%), P = 0.227. Genotype comparisons for both polymorphisms showed no significant difference (P > 0.05). The polymorphisms rs7799039 and rs13266634 were not associated with GDM in the population studied (P > 0.05). The minor allele frequencies for both polymorphisms were similar to those of other Caucasian populations.

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“…In the last decade, numerous other genetic studies for PTDM have been conducted in renal transplant recipients, and nearly 50 loci have been established as suspected loci (Table 4) [7][8][9][10]13,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. Polymorphisms in AIPOQ, CAPN10, CDKAL1, CDKN2A/B, HHEX, KCN11, KCNQ1, SLC30A8, and TCFL2 are known to be associated with T2DM.…”

Section: Discussionmentioning

confidence: 99%

“…Leptin (LEP) and leptin receptor (LEPR) gene polymorphisms have been reported to be associated with insulin resistance, obesity, and diabetes mellitus [11,12]. However, only a few studies have evaluated the clinical impact of LEP and LEPR polymorphisms on the development of PTDM [13].…”

Section: Introductionmentioning

confidence: 99%

Association of leptin receptor gene polymorphisms with post-transplant diabetes mellitus: Short report and literature review

Kim¹,

Ihm²,

Lee³

et al. 2017

Transplant Open

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Background: Post-transplant diabetes mellitus (PTDM) is a common and important metabolic complication after renal transplantation. Although genetic variants of the leptin (LEP) and leptin receptor (LEPR) gene have been reported to be associated with insulin resistance and diabetes mellitus, few studies have examined these variants in patients with post-transplant diabetes mellitus (PTDM). In this study, we investigated the association between LEP and LEPR polymorphisms and PTDM in renal transplant recipients. We also reviewed the literature on the genetic variants associated with development of PTDM.

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Adiponectin and Leptin Gene Polymorphisms in Patients With Post-Transplant Diabetes Mellitus

Abstract: The results of our study suggest an association between the leptin rs2167270 gene A allele and PTDM. Original submitted 27 February 2015; Revision submitted 22 May 2015.

Cited by 35 publications

References 36 publications

Genetic factors in pathogenesis of diabetes mellitus after kidney transplantation

Genetic factors in pathogenesis of diabetes mellitus after kidney transplantation

Leptin (rs7799039) and solute carrier family 30 zinc transporter (rs13266634) polymorphisms in Euro-Brazilian pregnant women with gestational diabetes

Association of leptin receptor gene polymorphisms with post-transplant diabetes mellitus: Short report and literature review

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