Adiponectin and resistin serum levels in women with polycystic ovary syndrome during oral glucose tolerance test: A significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices

Lewandowski, Krzysztof C.; Szosland, Konrad; O’Callaghan, Chris; Tan, Bee K.; Randeva, Harpal S.; Lewiński, Andrzej

doi:10.1016/j.ymgme.2004.12.014

Cited by 57 publications

(44 citation statements)

References 64 publications

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“…Furthermore, we showed that adiponectin treatment (5 mg/mL) rapidly increased MAPK, ERK1/2, and p38 phosphorylation. The concentration of adiponectin tested in vitro was physiological, as in rats and humans the average plasma adiponectin levels range from 3-20 mg/mL (27,37,38). Curiously, we did not observe an effect of adiponectin on AMPK phosphorylation, whereas recombinant adiponectin is able to activate AMPK in rat, chicken, and porcine GCs (24,26,27).…”

Section: Chabrolle Role Of Adiponectin In Human Granulosa Cells Fermentioning

confidence: 60%

Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells

Chabrolle

Tosca

Ramé

et al. 2009

Fertility and Sterility

150

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Section: Chabrolle Role Of Adiponectin In Human Granulosa Cells Fermentioning

confidence: 60%

Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells

Chabrolle

Tosca

Ramé

et al. 2009

Fertility and Sterility

150

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“…In the studies evaluating the response of adiponectin to acute hyperglycemia during OGTT, adiponectin levels were not changed 2 h after glucose load in insulin-sensitive slim probands [31] , as well as in normal glucose-tolerant, impaired glucosetolerant, and type 2 diabetic probands [32] , whereas an increase in adiponectin levels was observed in patients with polycystic ovary syndrome [33] . In the present study we detected an increased adiponectin response to oral glucose at 2 h during OGTT which was not present in nonacne healthy controls and was diminished after isotretinoin therapy.…”

Section: Discussionmentioning

confidence: 99%

Suppressed Adiponectin Levels and Increased Adiponectin Response to Oral Glucose Load in Lean Women with Severe Acne Normalizes after Isotretinoin Treatment

Aydín

Çetinözman²,

Elçin³

et al. 2017

Dermatology

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ide and adiponectin levels. Glucose metabolism markers in patients with acne and controls were similar at baseline and did not change after treatment. Baseline OGTT in acne patients revealed an increased adiponectin response at 2 h, which was not present in healthy controls. Remarkably, this OGTT-induced adiponectin increment in acne patients was diminished after isotretinoin treatment. Conclusion: Adiponectin levels are differently regulated in women with severe acne and healthy controls in that circulating basal levels in patients are suppressed and show an increase in response to oral glucose load. Suppression of baseline adiponectin ameliorates after 6 months of isotretinoin treatment, reaching levels similar to those of healthy controls.

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“…Although this topic has been investigated by many research groups, there is still no clear evidence of a direct relationship between hypoadiponectinemia and PCOS. A number of studies showed an independent decrease in adiponectin levels in PCOS patients [108,[112][113][114][115][116][117][118], but others failed to demonstrate a direct link between hypoadiponectinemia and PCOS [119][120][121][122][123][124][125][126][127][128][129]. Whether hypoadiponectinemia is or is not directly implicated in the development of PCOS, it surely participates in the insulin-resistant state observed in those patients, and there has been speculation that hypoadiponectinemia could be used to identify women with PCOS who are at higher risk for the future development of type 2 diabetes [130] and coronary artery diseases (CAD) [117].…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

Adiponectin action from head to toe

Brochu-Gaudreau

Rehfeldt

Blouin

et al. 2009

Endocr

281

247

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Adiponectin, the most abundant protein secreted by white adipose tissue, is known for its involvement in obesity-related disorders such as insulin resistance, type 2 diabetes mellitus and atherosclerosis. Moreover, modulation of the circulating adiponectin concentration is observed in pathologies that are more or less obesity-related, such as cancer and rheumatoid arthritis. The wide distribution of adiponectin receptors in various organs and tissues suggests that adiponectin has pleiotropic effects on numerous physiological processes. Besides its well-known insulin-sensitizing, anti-inflammatory and antiatherosclerotic properties, accumulating evidence suggests that adiponectin may also have anticancer properties and be cardioprotective. A beneficial effect of adiponectin on female reproductive function was also suggested. Since adiponectin has numerous beneficial biological functions, its use as a therapeutic agent has been suggested. However, the use of adiponectin or its receptors as therapeutic targets is complicated by the presence of different adiponectin oligomeric isoforms and production sites, by multiple receptors with differing affinities for adiponectin isoforms, and by cell-type-specific effects in different tissues. In this review, we discuss the known and potential roles of adiponectin in various tissues and pathologies. The therapeutic promise of administration of adiponectin and the use of its circulating levels as a diagnostic biomarker are further discussed based on the latest experimental studies.

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Adiponectin and resistin serum levels in women with polycystic ovary syndrome during oral glucose tolerance test: A significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices

Cited by 57 publications

References 64 publications

Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells

Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells

Suppressed Adiponectin Levels and Increased Adiponectin Response to Oral Glucose Load in Lean Women with Severe Acne Normalizes after Isotretinoin Treatment

Adiponectin action from head to toe

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