Adiponectin and vitamin D-binding protein are independently associated at birth in both mothers and neonates

Karras, Spyridon Ν.; Polyzos, Stergios A.; Newton, Danforth A.; Wagner, Carol L.; Hollis, Bruce W.; Ouweland, Jody van den; Dursun, Erdinç; Gezen-Ak, Duygu; Kotsa, Kalliopi; Annweiler, Cédric; Naughton, Declan P.

doi:10.1007/s12020-017-1475-2

Cited by 12 publications

(12 citation statements)

References 41 publications

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“…Recent results from our group, in maternal–neonatal pairs at birth, demonstrated an independent positive correlation of VDBP with adipokines, adiponectin, and irisin, which remained significant after adjustment for multiple parameters, including weeks of gestation, maternal age, and Body Mass Index, in both mothers and neonates (not for irisin in the case of neonates) ( 43 ). Further mechanistic studies are required to elucidate whether VDBP plays a carrier or regulatory role for adiponectin and/or irisin during pregnancy and its potential effects on offspring anthropometry in late childhood and adolescence.…”

Section: Vdbp As a Marker Of A Healthy Ongoing Pregnancy: Clinical Immentioning

confidence: 62%

Deconvoluting the Biological Roles of Vitamin D-Binding Protein During Pregnancy: A Both Clinical and Theoretical Challenge

et al. 2018

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The teleological purpose of an ongoing pregnancy is to fulfill its fundamental role of a successful, uncomplicated delivery, in conjunction with an optimal intrauterine environment for the developing fetus. Vitamin D metabolism is adapted to meet both these demands during pregnancy; first by stimulation of calcium absorption for adequate intrauterine bone mineral accrual of the fetus, and second, by enhancing systemic and local maternal tolerance to paternal and fetal alloantigens. Vitamin D-binding protein (VDBP) is one of the key biomolecules that optimize vitamin D homeostasis and also contributes as an immune regulator for a healthy, ongoing pregnancy. In this regard, recent results indicate that dysregulation of VDBP equilibrium could be a risk factor for adverse fetal, maternal, and neonatal outcomes, including preeclampsia, preterm birth, and gestational diabetes. Moreover, it has been hypothesized to be also implicated in the interpretation of vitamin D status in the pregnant state. The aim of this review is to assess available literature regarding the association of VDBP with clinical outcomes during pregnancy, as a potential biomarker for future clinical practice, with a discourse on current knowledge gaps and future research agenda.

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Section: Vdbp As a Marker Of A Healthy Ongoing Pregnancy: Clinical Immentioning

confidence: 62%

Deconvoluting the Biological Roles of Vitamin D-Binding Protein During Pregnancy: A Both Clinical and Theoretical Challenge

et al. 2018

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“…In another cross-sectional study in 70 pairs of newly-delivered Greek neonates and their mothers, irisin levels were also lower in the neonates [36]. A possible explanation for the higher irisin levels in labor-born neonates compared with cesarean-born ones could be related to physical stress during labor possibly mimicking physical activity.…”

Section: Association Of Circulating Irisin With Mother–offspring Rmentioning

confidence: 99%

Relationship of Circulating Irisin with Body Composition, Physical Activity, and Cardiovascular and Metabolic Disorders in the Pediatric Population

Elizondo‐Montemayor

Mendoza-Lara

Gutierrez-DelBosque

et al. 2018

IJMS

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Exercise-induced irisin, a recently discovered myokine, has been linked to insulin resistance, obesity, and other diseases in adults; however, information in children is scarce and contradictory. We analyzed the limited evidence of irisin’s effects in children and adolescents, and its association with body composition, exercise training, cardiovascular risk factors, and metabolic diseases, as well as the results of dietetic interventions. Both positive and negative correlations between irisin concentrations and body mass index, fat mass, fat-free mass, and other anthropometric parameters were found. Likewise, contradictory evidence was shown associating irisin plasma levels with cardiovascular and metabolic parameters such as glucose, insulin resistance, and cholesterol and other lipid and fatty acid plasma levels in healthy children, as well as in those with obesity and the metabolic syndrome. Gender, puberty, and hormonal differences were also examined. Furthermore, important contradictory findings according to the type and duration of exercise and of dietetic interventions in healthy and unhealthy subjects were demonstrated. In addition, correlations between mother–infant relations and circulating irisin were also identified. This review discusses the potential role of irisin in health and disease in the pediatric population.

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“…One possible mechanism by which vitamin D may act on glucose metabolism is by increasing adiponectin secretion (9,10) .…”

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confidence: 99%

Longitudinal association of 25-hydroxyvitamin D with adipokines and markers of glucose metabolism among Brazilian pregnant women

Benaim

Cocate

Barros³

et al. 2018

Br J Nutr

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This study aimed to evaluate the longitudinal association of vitamin D status with glycaemia, insulin, homoeostatic model assessment of insulin resistance, adiponectin and leptin. A prospective cohort with 181 healthy, pregnant Brazilian women was followed at the 5th–13th, 20th–26th and 30th–36th gestational weeks. In this cohort, 25-hydroxyvitamin D (25(OH)D) plasma concentrations were analysed using liquid chromatography–tandem MS. Vitamin D status was categorised as sufficient or insufficient using the Endocrine Society Practice Guidelines (≥75/<75 nmol/l) and the Institute of Medicine (≥50/<50 nmol/l) thresholds. Linear mixed-effect regression models were employed to evaluate the association between vitamin D status and each outcome, considering interaction terms between vitamin D status and gestational age (P<0·1). At baseline, 70·7 % of pregnant women had 25(OH)D levels <75 nmol/l and 16 % had levels <50 nmol/l. Women with sufficient vitamin D status at baseline, using both thresholds, presented lower glycaemia than those with insufficient 25(OH)D. Pregnant women with 25(OH)D concentrations <75 nmol/l showed lower insulin (β=−0·12; 95 % CI −0·251, 0·009;P=0·069) and adiponectin (β=−0·070; 95 % CI −0·150, 0·010;P=0·085) concentrations throughout pregnancy than those with 25(OH)D levels ≥75 nmol/l. Pregnant women with 25(OH)D <50 nmol/l at baseline presented significantly higher leptin concentrations than those with 25(OH)D levels ≥50 nmol/l (β=−0·253; 95 % CI −0·044, 0·550;P=0·095). The baseline status of vitamin D influences the biomarkers involved in glucose metabolism. Vitamin D-sufficient women at baseline had higher increases in insulin and adiponectin changes throughout gestation than those who were insufficient.

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Adiponectin and vitamin D-binding protein are independently associated at birth in both mothers and neonates

Cited by 12 publications

References 41 publications

Deconvoluting the Biological Roles of Vitamin D-Binding Protein During Pregnancy: A Both Clinical and Theoretical Challenge

Deconvoluting the Biological Roles of Vitamin D-Binding Protein During Pregnancy: A Both Clinical and Theoretical Challenge

Relationship of Circulating Irisin with Body Composition, Physical Activity, and Cardiovascular and Metabolic Disorders in the Pediatric Population

Longitudinal association of 25-hydroxyvitamin D with adipokines and markers of glucose metabolism among Brazilian pregnant women

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