Adiponectin attenuates human eosinophil adhesion and chemotaxis: implications in allergic inflammation

Yamamoto, Rie; Ueki, Shigeharu; Moritoki, Yuki; Kobayashi, Yoshiki; Oyamada, Hirokazu; Konno, Yasunori; Tamaki, Masaharu; Itoga, Masamichi; Takeda, Masahide; Ito, Wataru; Chihara, Junichi

doi:10.3109/02770903.2013.816725

Cited by 35 publications

(25 citation statements)

References 43 publications

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“…Next, we needed to determine the mechanism underlying the APN‐driven chemotaxis during the osteogenesis of h‐JBMMSCs. APN has already been reported to activate the adenosine monophosphate‐activated protein kinase (AMPK) signalling pathway by binding with the membrane receptor AdipoR1 . In addition, the results from our present study confirmed that APN could promote the osteogenesis of h‐JBMMSCs through the APPL1‐p38 MAPK signalling pathway .…”

Section: Discussionsupporting

confidence: 86%

Adiponectin promotes human jaw bone marrow mesenchymal stem cell chemotaxis via CXCL1 and CXCL8

Wang

Hong

et al. 2017

J Cellular Molecular Medi

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Adiponectin (APN) is known to promote the osteogenic differentiation of human jaw bone marrow mesenchymal stem cells (h‐JBMMSCs). However, the underlying mechanism has not been fully elucidated. Previously, we showed that APN could promote h‐JBMMSC osteogenesis via APPL1‐p38 by up‐regulating osteogenesis‐related genes. Here, we aimed to determine whether APN could promote h‐JBMMSC chemotaxis through CXCL1/CXCL8. The CCK‐8, wound healing and transwell assays were used to evaluate the proliferation, migration and chemotaxis of h‐JBMMSCs with or without APN treatment. Chemotaxis‐related genes were screened using RNA‐seq, and the results were validated using real‐time PCR and ELISA. We also performed Western blot using the AMPK inhibitor, WZ4003, and the p38 MAPK inhibitor, SB203580, to identify the signalling pathway involved. We found that APN could promote h‐JBMMSC chemotaxis in the co‐culture transwell system. CXCL1 and CXCL8 were screened and confirmed as the up‐regulated target genes. The APN‐induced CXCL1/8 up‐regulation to promote chemotaxis could be blocked by CXCR2 inhibitor SB225002. Western blot revealed that the phosphorylation of AMPK and p38 MAPK increased in a time‐dependent manner with APN treatment. Additionally, WZ4003 and SB203580 could suppress the APN‐induced overexpression of CXCL1 and CXCL8. The results of the transwell chemotaxis assay also supported the above results. Our data suggest that APN can promote h‐JBMMSC chemotaxis by up‐regulating CXCL1 and CXCL8.

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Section: Discussionsupporting

confidence: 86%

Adiponectin promotes human jaw bone marrow mesenchymal stem cell chemotaxis via CXCL1 and CXCL8

Wang

Hong

et al. 2017

J Cellular Molecular Medi

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“…52 The ability to induce migration of monocytes, macrophages and dendritic cells has been also documented in the case of chemerin. 53,54 In contrast, it has been reported that adiponectin inhibits eosinophil and endothelial cell chemotactic response, 55,56 whereas apelin suppresses chemotaxis of macrophages. 28 Therefore, activities mediated by adipokines seem to promote cell influx and their subsequent accumulation at the sites of ongoing inflammation.…”

Section: Adipokines Modulate the Activity Of Cells Engaged In Innatmentioning

confidence: 95%

The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview

2020

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Summary Adipokines are predominantly known to play a vital role in the control of food intake, energy homeostasis and regulation of glucose and lipid metabolism. However, evidence supporting the concept of their extensive involvement in immune system defence mechanisms and inflammatory processes continues to grow. Some of the adipokines, that is, leptin and resistin, have been recognized to exhibit mainly pro‐inflammatory properties, whereas others such as visfatin, chemerin, apelin and vaspin have been found to exert regulatory effects. In contrast, adiponectin or omentin are known for their anti‐inflammatory activities. Hence, adipokines influence the activity of various cells engaged in innate immune response and inflammatory processes mainly by affecting adhesion molecule expression, chemotaxis, apoptosis and phagocytosis, as well as mediators production and release. However, much less is known about the role of adipokines in processes involving lymphoid lineage cells. This review summarizes the current knowledge regarding the importance of different adipokines in the lymphopoiesis, recirculation, differentiation and polarization of lymphoid lineage cells. It also provides insight into the influence of selected adipokines on the activity of those cells in tissues.

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“…In contrast to leptin, Yamamoto et al demonstrated that the adiponectin receptors AdipoR1 and AdipoR2 were expressed on human peripheral blood eosinophils but that adiponectin, in a dose-dependent manner, attenuated eotaxin-induced eosinophil adhesion activity 41. However, no effects were observed on the survival of eosinophils.…”

Section: Introductionmentioning

confidence: 99%

Is There a Link Between Obesity and Asthma?

Kim

Sutherland

Gelfand

2014

Allergy Asthma Immunol Res

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Increasing epidemiological data identify a link between obesity and asthma incidence and severity. Based on experimental data, it is possible that shared inflammatory mechanisms play a role in determining this linkage. Although controversial, the role of adipokines may be central to this association and the maintenance of the asthma phenotype. While leptin and adiponectin have a causal link to experimental asthma in mice, data in humans are less conclusive. Recent studies demonstrate that adipokines can regulate the survival and function of eosinophils and that these factors can affect eosinophil trafficking from the bone marrow to the airways. In addition, efferocytosis, the clearance of dead cells, by airway macrophages or blood monocytes appears impaired in obese asthmatics and is inversely correlated with glucocorticoid responsiveness. This review examines the potential mechanisms linking obesity to asthma.

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Adiponectin attenuates human eosinophil adhesion and chemotaxis: implications in allergic inflammation

Cited by 35 publications

References 43 publications

Adiponectin promotes human jaw bone marrow mesenchymal stem cell chemotaxis via CXCL1 and CXCL8

Adiponectin promotes human jaw bone marrow mesenchymal stem cell chemotaxis via CXCL1 and CXCL8

The role of adipokines in the modulation of lymphoid lineage cell development and activity: An overview

Is There a Link Between Obesity and Asthma?

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