Adiponectin gene variants, adiponectin isoforms and cardiometabolic risk in type 2 diabetic patients

Abstract

Aims/Introduction: The aim of the present study was to examine the associations of rs2241766 (+45T>G), rs1501299 (+276G>T), rs17300539 (-11391G>A) and rs182052 (-10069G>A) in the adiponectin (Ad) gene with adiponectin concentrations, and concomitantly the association of these variants with cardiometabolic risk in type 2 diabetic patients of African ancestry. Materials and Methods: A cross-sectional study of 200 patients was carried out. Concentrations of total, high (HMW), middle (MMW) and low (LMW) molecular weight adiponectin isoforms were measured. The four polymorphisms were genotyped. Results: Decreased values were noted for total Ad in overweight, dyslipidemia and coronary artery disease (CAD), for HMW in overweight and dyslipidemia, for MMW in CAD, for LMW in dyslipidemia and CAD, for the percentage HMW/total in overweight, and for MMW:HMW ratio in patients without hypertriglyceridemic waist (HTGW). Significant associations were noted between total Ad, HMW, and HMW/total Ad and rs182052 under a dominant model (P = 0.04, P = 0.03 and P = 0.04, respectively), and between MMW and rs17300539 (P = 0.006). No significant difference in adiponectin concentrations was noted according to rs2241766 and rs1501299 genotypes. Patients carrying the rs2241766 G allele (TG+GG) had an increased risk of HTGW (odds ratio [OR] 3.1; P = 0.04) and of CAD (OR 3.3; P = 0.01). The odds of having low total adiponectin concentrations (<25th percentile: 3.49 ng/mL) for carrying the rs182052A allele (AA+GA) was: OR 0.40; P = 0.009. The single-nucleotide polymorphism associated with adiponectin levels was not concomitantly associated with cardiometabolic risk factors. Conclusions: Adiponectin concentrations and ADIPOQ variants are implicated in the pathophysiological process leading to cardiovascular diseases, but the genetic effects seem to be independent of adiponectin concentrations in our Afro-Caribbean diabetic patients.

Association of Adiponectin Gene Polymorphisms With the Risk of Coronary Artery Disease in Patients With Nonalcoholic Fatty Liver Disease in a Chinese Han Population

“…A recent meta-analysis concluded that there was a strong association between Ad rs266729 and cardiovascular disease ( 33 ). In agreement with previous studies, Foucan et al ( 34 ) showed that French patients carrying the Ad rs2241766 G allele had an increased risk of CAD. Other studies have reported discordant findings because of differences in ethnicity, phenotypes, and environments ( 16 , 33 ).…”

Adiponectin and leptin gene polymorphisms in women with gestational diabetes mellitus

“…Decreased plasma adiponectin levels were observed in patients with metabolic syndrome, diabetes mellitus, dyslipidaemia and obesity [7]. Previous studied suggest also significant associations between adiponectin gene polymorphisms and diabetes mellitus, metabolic syndrome, and obesity [8,9]. The aim of this study was to examine the association between adiponectin and leptin gene polymorphisms and the development of gestational diabetes.…”

Associations between two common single nucleotide polymorphisms (rs2241766 and rs1501299) of ADIPOQ gene and coronary artery disease in type 2 diabetic patients: a systematic review and meta-analysis

“…The rs2241766 polymorphism is a T/G substitution in exon2 and the rs1501299 is a G/T substitution in intron2. The influence of the two SNPs on CAD have been investigated in patients with T2DM, [ 15 – 17 ] the results are inconsistent. In the study of Bacci et al [ 18 ] and Filippi et al[ 19 ], no association was found between the rs2241766 polymorphism and CAD risk in T2DM patients.…”